Migration-Dependent Signalling in Macrophages . The project aims to investigate a mechanism of communication used by immune cells to guide each other towards sites of damage. The project will characterise newly revealed cell signalling membrane trails left behind by migrating cells, utilising biochemistry, innovative imaging and microscopy and a transparent zebrafish model to view cell migration through living tissues. Expected outcomes include new fundamental knowledge in the area of immune cel ....Migration-Dependent Signalling in Macrophages . The project aims to investigate a mechanism of communication used by immune cells to guide each other towards sites of damage. The project will characterise newly revealed cell signalling membrane trails left behind by migrating cells, utilising biochemistry, innovative imaging and microscopy and a transparent zebrafish model to view cell migration through living tissues. Expected outcomes include new fundamental knowledge in the area of immune cell migration with relevance to the basic biology of inflammation, repair and regeneration and new innovations for cell imaging. Significant benefits are expected to arise from this new knowledge and from advanced skills training and improved national capabilities in bio-imaging and analysis.Read moreRead less
Identifying how cortical bone microstructure deteriorates with age. This project aims to define the disruptions responsible for the gradual weakening of the skeleton in ageing by integrating a range of high-resolution imaging, biomechanical, and computational methods. The expected significance of this project includes a full definition and comparison of the cellular and subcellular organisation of bone from young and elderly individuals. Expected outcomes of this international project include th ....Identifying how cortical bone microstructure deteriorates with age. This project aims to define the disruptions responsible for the gradual weakening of the skeleton in ageing by integrating a range of high-resolution imaging, biomechanical, and computational methods. The expected significance of this project includes a full definition and comparison of the cellular and subcellular organisation of bone from young and elderly individuals. Expected outcomes of this international project include the establishment of a new multidisciplinary research team, and the development of a new data-driven theoretical framework for understanding the nature and the causes of age-related bone fragility. Potential long-term benefits include new ways to treat age-related osteoporosis.Read moreRead less