REACH: Randomised Trial Of EArly Rehabilitation In Congenital Hemiplegia
Funder
National Health and Medical Research Council
Funding Amount
$972,777.00
Summary
Infants with asymmetric brain lesions are at high risk of congenital hemiplegia. This study compares modified CIMT to an equal dose of bimanual training in 150 infants recruited at 3-6 months. Both therapies will be parent-delivered supported by experienced clinicians. Outcomes include use of the impaired hand in bimanual tasks, cognitive and motor development at 12 and 24 months c.a. with measures of neural structure and functional connectivity at 24 months. Early interventions that attenuate
A Pedagogy for Multiliteracies with Information and Communication Technologies in Early Childhood Education. The goal of this project is to determine the most effective pedagogy for the use of ICT in Australian early childhood education. The research is essential in order to plan for a world-class educational future for young Australians. A collaborative action-research program will be undertaken by three leading academics in association with a network of thirty-six teachers in three states. Thi ....A Pedagogy for Multiliteracies with Information and Communication Technologies in Early Childhood Education. The goal of this project is to determine the most effective pedagogy for the use of ICT in Australian early childhood education. The research is essential in order to plan for a world-class educational future for young Australians. A collaborative action-research program will be undertaken by three leading academics in association with a network of thirty-six teachers in three states. This innovative research approach is based on a multiliteracies framework. The project will investigate how ICT can best be used for enhancing children's learning and identify specific ways in which teachers can develop multiliteracies in early childhood education environments. Read moreRead less
Australasian Cerebral Palsy Clinical Trials Network (AusCP-CTN): Optimising Interventions And Effective Services For Children With Cerebral Palsy
Funder
National Health and Medical Research Council
Funding Amount
$2,499,287.00
Summary
Cerebral Palsy (CP) is common and disability can be progressive so the heathcare burden is immense (0.14% GDP). Our Clinical trials network will improve early detection and develop new interventions to improve physical, cognitive and health outcomes for children with CP and their families. Recruitment from the national CP Register will address clinically important questions and test implementation of effective treatments. New Clinical Practice Guidelines will ensure translation internationally.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100074
Funder
Australian Research Council
Funding Amount
$520,000.00
Summary
Facilities for automated high-throughput slide scanning and stereology. The equipment requested will facilitate the work of the Australian Mouse Brain Mapping Consortium, a consortium of Australian research groups collaborating to provide the only mouse model brain mapping capability in the country. The consortium brings together laboratory, neuroimaging and computational expertise in a comprehensive framework for imaging the mouse brain. This will help researchers to study mouse models of genet ....Facilities for automated high-throughput slide scanning and stereology. The equipment requested will facilitate the work of the Australian Mouse Brain Mapping Consortium, a consortium of Australian research groups collaborating to provide the only mouse model brain mapping capability in the country. The consortium brings together laboratory, neuroimaging and computational expertise in a comprehensive framework for imaging the mouse brain. This will help researchers to study mouse models of genetic and acquired disorders across the life-span. Remote viewing and analysis capabilities will help overcome the 'tyranny of distance', increasing national access to the facility. Repositories of digitised images will increase the availability of valuable research material to other Australian and international researchers.Read moreRead less
Cost effective smart identification of early attentional problems associated with literacy and numeracy indicators in preschool children. The benefits of this project are improved early identification of children at-risk of failure, and initiation of a significant longitudinal Australian educational database. Identifying children with emergent learning problems will promote interventions to improve achievement leading to a more productive adult life. The development and administration of screeni ....Cost effective smart identification of early attentional problems associated with literacy and numeracy indicators in preschool children. The benefits of this project are improved early identification of children at-risk of failure, and initiation of a significant longitudinal Australian educational database. Identifying children with emergent learning problems will promote interventions to improve achievement leading to a more productive adult life. The development and administration of screening procedures with software distributed to schools and analysed with increasing power as the database expands, will enable the predictive validity of the process to be examined re-iteratively. The generated longitudinal student databases will have the potential to track both detection and intervention effectiveness, and become a national research asset.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150100731
Funder
Australian Research Council
Funding Amount
$361,744.00
Summary
Contextual supports for the early development of self-regulated learning. How do young children develop critical learning behaviours that are the key for their future academic success? What kinds of environments support this development? This project aims to answer these questions by investigating the development of regulatory behaviours (with a specific focus on self-regulated learning) during the first two years of schooling, and identifying critical contextual variables at home and at school ....Contextual supports for the early development of self-regulated learning. How do young children develop critical learning behaviours that are the key for their future academic success? What kinds of environments support this development? This project aims to answer these questions by investigating the development of regulatory behaviours (with a specific focus on self-regulated learning) during the first two years of schooling, and identifying critical contextual variables at home and at school impacting on this development. Findings from this research will provide crucial information for the design of family and practitioner-based interventions helping to improve the educational outcomes of young Australians.Read moreRead less
Neurological cell replacement therapies: improving outcomes by matching developmental profiles of transplanted cells with the damaged brain area. Stem cell transplantation offers a way to replace nerve cells lost due to acute CNS injury or chronic degenerative conditions such as Parkinson's Disease. However, to date, results have been disappointing because of poor differentiation, survival and integration of stem cells confounded by ethical issues associated with the use of embryos as the source ....Neurological cell replacement therapies: improving outcomes by matching developmental profiles of transplanted cells with the damaged brain area. Stem cell transplantation offers a way to replace nerve cells lost due to acute CNS injury or chronic degenerative conditions such as Parkinson's Disease. However, to date, results have been disappointing because of poor differentiation, survival and integration of stem cells confounded by ethical issues associated with the use of embryos as the source of stem cells. The experiments conducted in this study will provide strategies to improve the efficacy of stem cell transplantation into the damaged CNS as well as developing the use of autologous bone marrow stem cells for repair. Outcomes will be improved transplant methodologies and expertise for the bio-technology industry. Read moreRead less
Characterisation Of Eurl, A Novel Gene Implicated In The Etiology Of Abnormal Brain Development And Intellectual Disability
Funder
National Health and Medical Research Council
Funding Amount
$597,541.00
Summary
Intellectual disability affects around one per cent of Australians, and can arise from genetic abnormalities during fetal life, such as through abnormal regulation of gene expression. We have identified a novel gene, known as eurl, which controls brain assembly as well as the ability of neurons to form functional connections within the brain. We will investigate how this novel gene controls brain development, and characterise eurl as a potential therapeutic target for learning and memory.
Parents as Partners: Getting children off to a healthy start in literacy. Our nation is best served by children getting off to a healthy start in literacy. However, almost one in six children fails to do so. This group has reduced academic and vocational options, increased social, emotional and mental health problems, higher youth unemployment, and is significantly over-represented among offenders. The nation bears the costs of these problems through reduced productivity and expenditure on unemp ....Parents as Partners: Getting children off to a healthy start in literacy. Our nation is best served by children getting off to a healthy start in literacy. However, almost one in six children fails to do so. This group has reduced academic and vocational options, increased social, emotional and mental health problems, higher youth unemployment, and is significantly over-represented among offenders. The nation bears the costs of these problems through reduced productivity and expenditure on unemployment benefits, social programs, mental health services, and incarceration. This project targets both these sources of loss to the nation by utilising a hitherto untapped community resource: Training parents of preschoolers to develop critical pre-literacy skills in their children at home before they begin to fail. Read moreRead less
Enhancing the content and experience of Interactive Childrens Television. Interactive television (iTV) as a participatory, on-demand communication provides a unique opportunity to significantly engage, entertain and educate preschool children. Through considerable industry partner collaboration and participation, this project will evaluate three distinct interactive options produced from selected children's television programs with proven success in Australia. Usability studies employing a vari ....Enhancing the content and experience of Interactive Childrens Television. Interactive television (iTV) as a participatory, on-demand communication provides a unique opportunity to significantly engage, entertain and educate preschool children. Through considerable industry partner collaboration and participation, this project will evaluate three distinct interactive options produced from selected children's television programs with proven success in Australia. Usability studies employing a variety of surveillance techniques will evaluate content design and user response. Children's viewing habits will be evaluated within a social context (the home) and a mobile lab setting using qualitative and quantitative assessment. The results will identify effective ways to produce meaningful interactivity and will encourage future industry based research.Read moreRead less