Pubertal Transitions In Mental Health And Behaviour: The PHASE-A Study Of Social Roleand Lifestyle Transitions
Funder
National Health and Medical Research Council
Funding Amount
$1,656,785.00
Summary
Over the past four decades problems such as depression, anxiety, self-harm and substance abuse have increased in young people. Recent research indicates that puberty is a time when these problems commonly first emerge. This five-year study of 4000 students will examine a question of whether social transitions that are too soon (e.g. early initiation of sex) or problematic (e.g. bullying from peers) may explain the increase in these health problems as children pass through puberty.
An inability to resist a temptation or repeated failures of self-regulation can lead to 'impulsive' and 'compulsive' behaviours that relate to a host of personal and social problems (eg., excessive eating, gambling, and substance use). Despite this, very little research has studied the neural and psychological underpinnings of these behaviours. My research will take advantage of recent innovations and approaches to fill this void and have implications for diagnosis and treatment.
Pathogen sensing in systemic inflammatory disease. The initiation, amplification and quenching of an immune response is a carefully orchestrated process that eliminates invading pathogens while minimising collateral damage to host tissues. This research focuses on proteins that restrict immune responses to prevent inflammatory diseases such as rheumatoid arthritis, psoriasis and inflammatory bowel disease. This work will also explore the role of a potassium channel that protects the host from or ....Pathogen sensing in systemic inflammatory disease. The initiation, amplification and quenching of an immune response is a carefully orchestrated process that eliminates invading pathogens while minimising collateral damage to host tissues. This research focuses on proteins that restrict immune responses to prevent inflammatory diseases such as rheumatoid arthritis, psoriasis and inflammatory bowel disease. This work will also explore the role of a potassium channel that protects the host from organ failure during an infection, by coupling the energy requirements of mounting an immune response, and organ function. This may have important implications for the management of sepsis, a systemic immune response associated with infection and the leading cause of death in critically ill patients.Read moreRead less
Engineering functional nerves using microtailored culture systems. The aim of this work is to develop new culture systems for developing and growing nerves outside of the body. The project will generate knowledge and engineering technology for production of neural implants suitable for medical applications. The availability of engineered nerve grafts to repair neural injuries will improve patient health outcomes.
An RNA interference based genetic screen for novel epigenetic modifiers involved in mammalian X inactivation. All the information required to form an adult human is contained in the DNA of the fertilized egg. Development is achieved by a complex orchestration of genes being switched on and off, controlled by proteins called epigenetic modifiers. Sometimes this goes awry, leading to disease. Despite their vital role, only around ten percent of the potential epigenetic modifiers have been characte ....An RNA interference based genetic screen for novel epigenetic modifiers involved in mammalian X inactivation. All the information required to form an adult human is contained in the DNA of the fertilized egg. Development is achieved by a complex orchestration of genes being switched on and off, controlled by proteins called epigenetic modifiers. Sometimes this goes awry, leading to disease. Despite their vital role, only around ten percent of the potential epigenetic modifiers have been characterized in humans, making it impossible to interpret how they work together, or when they fail. We will develop a novel screen-based technology to find hundreds more true epigenetic modifiers. This technology will aid us and other Australian scientists to understand the role of epigenetics in normal development and disease, ultimately leading to better public health.Read moreRead less
New genes and models for inflammatory bowel disease. Inflammatory bowel disease affecting millions of people world-wide and results in a significant economic burden ($100M in Australia per year). In collaboration with Australia’s largest biotechnology company, CSL, we will use a novel approach to discover the causes of inflammatory bowel disease. This work will lead to the development of new animal models of inflammatory bowel disease that are vital for analysing the disease and testing treatmen ....New genes and models for inflammatory bowel disease. Inflammatory bowel disease affecting millions of people world-wide and results in a significant economic burden ($100M in Australia per year). In collaboration with Australia’s largest biotechnology company, CSL, we will use a novel approach to discover the causes of inflammatory bowel disease. This work will lead to the development of new animal models of inflammatory bowel disease that are vital for analysing the disease and testing treatment options. In addition, this work may lead to new approaches to treating this disease. The project will result in a greater understanding of inflammatory bowel disease, the training of highly skilled scientists and potentially lead to economically valuable knowledge.Read moreRead less
Ocular Motility In Autism And Asperger S Disorder: Dissociation Of Motor Deficits.
Funder
National Health and Medical Research Council
Funding Amount
$131,235.00
Summary
We will use ocular motor technology to investigate motor dysfunction in autism and Asperger's disorder, to advance our understanding of the neurobiological bases of these disorders. This will help clarify whether neural networks are differentially disrupted in these disorders, as our previous clinical research suggests. This dissociation and the subsequent development of an ocular motor clincal screen may improve diagnosis, and potentially treatment, of these devastating conditions.
Transcriptional regulation of erythropoiesis. The major expected outcome from this proposal will be development of a pipeline for the study of how transcription factors work at a genome level. There will be national benefit in the areas of Frontier Technologies, and Promoting and Maintaining Good Health. There will be specific outcomes with respect to development of tests for human blood diseases, future design of drugs to target the aberrant activities of transcription factors in genetic and de ....Transcriptional regulation of erythropoiesis. The major expected outcome from this proposal will be development of a pipeline for the study of how transcription factors work at a genome level. There will be national benefit in the areas of Frontier Technologies, and Promoting and Maintaining Good Health. There will be specific outcomes with respect to development of tests for human blood diseases, future design of drugs to target the aberrant activities of transcription factors in genetic and degenerative diseases. Also, a strong bridge will be built upon the previous collaborations of the research teams in Brisbane and Pennsylvania, which will facilitate advanced teaching and training of Australian PhD and post-doctoral scientists.Read moreRead less
Emerging Severe Mental Illness In Young People: Clinical Staging, Neurobiology, Prediction & Intervention From Vulnerabi
Funder
National Health and Medical Research Council
Funding Amount
$6,229,421.00
Summary
Mental disorders, such as psychotic and severe mood disorders, are the largest cause of disability in Australia. However, there is still little known about illness onset, relapse and progression. We have developed a clinical staging model with transition points from symptomfree to subthreshold status, to threshold disorder to chronic disability. We will investigate neurobiological and psychosocial factors which increase the risk of progression through these stages and use this model as a basis f ....Mental disorders, such as psychotic and severe mood disorders, are the largest cause of disability in Australia. However, there is still little known about illness onset, relapse and progression. We have developed a clinical staging model with transition points from symptomfree to subthreshold status, to threshold disorder to chronic disability. We will investigate neurobiological and psychosocial factors which increase the risk of progression through these stages and use this model as a basis for examining the effectiveness of interventions, for example to prevent, delay or ameliorate onset and relapse, and promote vocational recovery. Thus major clinical and public health benefits and an understanding of factors that contribute to the onset and progression of illness will result.Read moreRead less
Fluid Dynamics of Circulation: Focus on the Kidney. In Australia, about 30% of adults have hypertension, a major risk factor for heart disease, accounting for about 40% of all deaths. Problems in renal circulation are likely factors leading to hypertension. A detailed understanding of the renal circulation, of whose hydraulic characteristics we have limited knowledge, is required before we can cure or prevent hypertension. We will determine how the size, structure and geometry of the blood vesse ....Fluid Dynamics of Circulation: Focus on the Kidney. In Australia, about 30% of adults have hypertension, a major risk factor for heart disease, accounting for about 40% of all deaths. Problems in renal circulation are likely factors leading to hypertension. A detailed understanding of the renal circulation, of whose hydraulic characteristics we have limited knowledge, is required before we can cure or prevent hypertension. We will determine how the size, structure and geometry of the blood vessels influence the function of the kidney. This will lead to predictive models to aid the design and interpretation of physiological studies and the combat of hypertension. It will also help in the ongoing development of bioartificial kidneys to replace present dialysis systems. Read moreRead less