Engineering of cartilage-based biomaterials under dynamic culture conditions. This work contributes to the development of advanced technologies in the area of biomaterials. The cartilage biomaterials generated in this work will lead to new medical applications in tissue reconstruction and replacement, which is of direct benefit to society by improving the methods used to treat joint disease and injury. As there is a significant commercial market for tissue-engineered cartilage products, this res ....Engineering of cartilage-based biomaterials under dynamic culture conditions. This work contributes to the development of advanced technologies in the area of biomaterials. The cartilage biomaterials generated in this work will lead to new medical applications in tissue reconstruction and replacement, which is of direct benefit to society by improving the methods used to treat joint disease and injury. As there is a significant commercial market for tissue-engineered cartilage products, this research also has implications for enhancing the scope and profitability of the Australian biotechnology industry. The project will be a vehicle for research training in a broad range of interdisciplinary areas. Students involved in the work will be equipped with a versatile and valuable combination of skills.Read moreRead less
Application of bioreactors for culture of differentiated cells and solid-phase tissues. The aim of this project is to develop methods for producing three-dimensional human cartilage outside of the body. Tissue-engineered cartilage has a range of applications, including in toxicity testing, for production of therapeutics, and as surgical transplant devices. Bioreactors will be used to culture cartilage under controlled conditions for development of living tissues with properties as close as possi ....Application of bioreactors for culture of differentiated cells and solid-phase tissues. The aim of this project is to develop methods for producing three-dimensional human cartilage outside of the body. Tissue-engineered cartilage has a range of applications, including in toxicity testing, for production of therapeutics, and as surgical transplant devices. Bioreactors will be used to culture cartilage under controlled conditions for development of living tissues with properties as close as possible to those of native articular cartilage. Novel culture strategies will be used to enhance the availability of growth factors and provide adequate oxygen and nutrient exchange. These techniques have the potential to yield significant improvements in the quality of engineered cartilage.Read moreRead less
Scalable, high throughput microfluidic platforms for tissue specific biomaterials development and tissue genesis. The co-development of novel biomaterial platforms and new generation production methods for tissue analogues will provide the necessary stimulus for improved and more relevant methods of enhanced repair or regeneration of diseased or damaged tissues. These outcomes will result in faster time-to-market new generation therapeutic products for Australia and the world. These advances wil ....Scalable, high throughput microfluidic platforms for tissue specific biomaterials development and tissue genesis. The co-development of novel biomaterial platforms and new generation production methods for tissue analogues will provide the necessary stimulus for improved and more relevant methods of enhanced repair or regeneration of diseased or damaged tissues. These outcomes will result in faster time-to-market new generation therapeutic products for Australia and the world. These advances will have a significant impact on our healthcare costs and the quality of life for all Australians.Read moreRead less
Clean technologies for the synthesis and purification of a biohybrid and biodegradable polymer. The project aims to transform an Australian industry in the forefront of the global market for manufacturing biodegradable polymers and boost export earnings derived from CO2 based biohybrid polymers. The project will develop cost-effective and clean methods for processing CO2 based polymers and demonstrate its potential for packaging and biomedical applications.
On-demand 3D polymer scaffolds for directed stem cell differentiation. The project will develop new polymer gels that can be sculpted into shapes, representing tissues and organs. This 3D scaffold will provide a surface with biological signals to create functional tissues from stem cells. The approach will create engineered intestinal tissue with great promise to increase the survival rates of colon cancer patients.
Very thin, highly oriented and featured diamond films. The technology for making very thin diamond films, having sculpted surface features and fabricated from tiny and highly oriented individual diamond crystallites, would enable widespread potential applications, including eg surface acoustic wave devices, optical biosensors for ?lab-on-a-chip?, and field emitter arrays for paper thin, bright and wide angle flat panel displays, amongst others. Diamond is uniquely suited to these applications, ....Very thin, highly oriented and featured diamond films. The technology for making very thin diamond films, having sculpted surface features and fabricated from tiny and highly oriented individual diamond crystallites, would enable widespread potential applications, including eg surface acoustic wave devices, optical biosensors for ?lab-on-a-chip?, and field emitter arrays for paper thin, bright and wide angle flat panel displays, amongst others. Diamond is uniquely suited to these applications, and the capability to manipulate film properties and features which is the key requirement, is within grasp.Read moreRead less
Production of hydrogen from biomass by integrated catalytic aqueous hydrolysis and reforming in subcritical water. The outcomes of this project will lead to the development of a novel process for efficient and cost-effective hydrogen production from renewable biomass using integrated hydrolysis and catalytic aqueous reforming at low temperatures. Such technological innovation will provide significant benefits to Australia as a whole for transition to a truly sustainable hydrogen economy. The nov ....Production of hydrogen from biomass by integrated catalytic aqueous hydrolysis and reforming in subcritical water. The outcomes of this project will lead to the development of a novel process for efficient and cost-effective hydrogen production from renewable biomass using integrated hydrolysis and catalytic aqueous reforming at low temperatures. Such technological innovation will provide significant benefits to Australia as a whole for transition to a truly sustainable hydrogen economy. The novel reaction system and research methodologies proposed in this proposal will certainly enhance Australia's science and technology capability and international competitiveness, in the area of reaction engineering. Also of the national benefit is the successful training of a postgraduate at PhD level who will no doubt add to future scientific research workforce.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100952
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
A chemical looping process for carbon fibre production from plastics. This project aims to develop Mineral Looping Plastic Reforming (MLPR), a chemical looping reforming process for tonnage production of carbon nanofibers from plastic waste. This efficient process uses naturally occurring minerals (limestone, dolomite and ilmenite) to convert plastic waste to carbon nanofibers. The project will research the inner working of the MLPR process and the reforming reactions of plastics in the presence ....A chemical looping process for carbon fibre production from plastics. This project aims to develop Mineral Looping Plastic Reforming (MLPR), a chemical looping reforming process for tonnage production of carbon nanofibers from plastic waste. This efficient process uses naturally occurring minerals (limestone, dolomite and ilmenite) to convert plastic waste to carbon nanofibers. The project will research the inner working of the MLPR process and the reforming reactions of plastics in the presence of naturally occurring mineral mixtures. This project is expected to make Australia a leader in waste use, facilitate the uptake of abundant waste streams to produce high value products, and resolve sustainability, energy and environmental issues in Australia.Read moreRead less
Improvements and Optimisation of Water Electrolysis for Hydroxy Gas Production for Metal Cutting Applications. The current technique for metal cutting mainly uses oxygen-acetylene flames, which means for the large number of Australian remote communities oxygen and acetylene bottles have to be transported from major cities. This incurs significant transport costs and associated environmental emissions and presents major safety concerns. Hydroxy flames using electrolysis of water can alleviate the ....Improvements and Optimisation of Water Electrolysis for Hydroxy Gas Production for Metal Cutting Applications. The current technique for metal cutting mainly uses oxygen-acetylene flames, which means for the large number of Australian remote communities oxygen and acetylene bottles have to be transported from major cities. This incurs significant transport costs and associated environmental emissions and presents major safety concerns. Hydroxy flames using electrolysis of water can alleviate these problems and, by utilising renewable electricity, the new technology to be developed in this research will transform tens of thousands of Australian metal workshops to be more environmentally friendly, safer and more cost-effective, thus contributing to the development of an environmentally sustainable Australia. Read moreRead less
Supercritical-microfluidics technology for targeted delivery to the colon. This research will develop nanosystems to target delivery of drugs to the colon. Our nanosystems will permit the combination of clinically used chemotherapy drugs within a single dosage form. This will improve the efficiency of delivery to the colon while reducing unwanted side-effects. A novel supercritical microfluidics system will be developed to produce therapeutic nano-carriers in a continuous mode with lower labour ....Supercritical-microfluidics technology for targeted delivery to the colon. This research will develop nanosystems to target delivery of drugs to the colon. Our nanosystems will permit the combination of clinically used chemotherapy drugs within a single dosage form. This will improve the efficiency of delivery to the colon while reducing unwanted side-effects. A novel supercritical microfluidics system will be developed to produce therapeutic nano-carriers in a continuous mode with lower labour requirement, higher production rate and better quality control than conventional production methods. The new process will combine benefits from both supercritical fluid technology (green process) and microfluidics (high mass & heat transfer).Read moreRead less