Novel Fermion Actions for Lattice Gauge Theory. The Standard Model of the universe is founded on quantum field theories in which gauge bosons mediate the forces between fermions, the constituents of matter. For example, the gluon of Quantum Chromodynamics (QCD) mediates the strong interactions between quarks as they compose protons, and neutrons. The only way to reveal the long-distance properties of this fundamental gauge theory from first principles is to numerically simulate the theory on a s ....Novel Fermion Actions for Lattice Gauge Theory. The Standard Model of the universe is founded on quantum field theories in which gauge bosons mediate the forces between fermions, the constituents of matter. For example, the gluon of Quantum Chromodynamics (QCD) mediates the strong interactions between quarks as they compose protons, and neutrons. The only way to reveal the long-distance properties of this fundamental gauge theory from first principles is to numerically simulate the theory on a space-time lattice. Simulating fermions on a lattice has proved very challenging. This project will explore novel and innovative improved fermion algorithms for the general problem of gauge theories on the lattice.Read moreRead less
Novel Mass Spectrometric Approaches to the Study of Protein-Protein Interactions. Protein-protein interactions mediate all fundamental cellular processes, yet the structural complexity of protein assemblies mean they are often difficult to characterise using traditional analytical methods. This project will develop and demonstrate novel mass spectrometric approaches towards a molecular level description of the structure and interactions of biological protein complexes, which in turn may underpi ....Novel Mass Spectrometric Approaches to the Study of Protein-Protein Interactions. Protein-protein interactions mediate all fundamental cellular processes, yet the structural complexity of protein assemblies mean they are often difficult to characterise using traditional analytical methods. This project will develop and demonstrate novel mass spectrometric approaches towards a molecular level description of the structure and interactions of biological protein complexes, which in turn may underpin the rational design of drugs for the treatment of a range of human health conditions. This project will also provide training of young researchers to the highest international standards in mass spectrometry and protein science, for benefit to Australian industry and research.Read moreRead less
Negative ion mass spectrometry: fundamentals and applied applications. 1. We seek to establish negative ion mass spectrometry as a major technological tool for the sequencing of peptides and proteins. In this context, we will investigate the structures and modes of action of peptide complexes which may be of importance for the treatment and control of heart disease and stroke.
2. Negative ions of known structure will be converted (in the mass spectrometer) into transient (and reactive) molecule ....Negative ion mass spectrometry: fundamentals and applied applications. 1. We seek to establish negative ion mass spectrometry as a major technological tool for the sequencing of peptides and proteins. In this context, we will investigate the structures and modes of action of peptide complexes which may be of importance for the treatment and control of heart disease and stroke.
2. Negative ions of known structure will be converted (in the mass spectrometer) into transient (and reactive) molecules which are present in interstellar ice and dust clouds. The structures and chemistry of such molecules are of importance in understanding the origins of life on this planet.Read moreRead less
Negative ion mass spectrometry: fundamental studies and applied applications. We seek to:
(i) establish negative ion mass spectrometry as an analytical tool for the sequencing of proteins and to probe the structures of active peptide Ca2+ calmodulin complexes which, for example, inhibit the formation of NO from nitric oxide synthases. Controlling the concentration of nitric oxide may assist with the treatment of inflammatory and cardiac diseases, stroke and diseases of the central nervous syst ....Negative ion mass spectrometry: fundamental studies and applied applications. We seek to:
(i) establish negative ion mass spectrometry as an analytical tool for the sequencing of proteins and to probe the structures of active peptide Ca2+ calmodulin complexes which, for example, inhibit the formation of NO from nitric oxide synthases. Controlling the concentration of nitric oxide may assist with the treatment of inflammatory and cardiac diseases, stroke and diseases of the central nervous system.
(ii) to study the possibility of the formation of biological molecules of life in interstellar regions
(iii) to train graduate students to international standards in the chemistry of proteomics.Read moreRead less
The Essence of QCD Vacuum Structure. This first-principles study of quantum field theory will elucidate an outstanding mystery of modern particle physics. Understanding confinement is recognized as one of the top 10 Physics Questions to Ponder for a Millennium or Two. In support of the National Research Priorities, new scientific data visualization techniques will be transferred to industry, facilitating smart information use. Further economic benefits are realized through the training and devel ....The Essence of QCD Vacuum Structure. This first-principles study of quantum field theory will elucidate an outstanding mystery of modern particle physics. Understanding confinement is recognized as one of the top 10 Physics Questions to Ponder for a Millennium or Two. In support of the National Research Priorities, new scientific data visualization techniques will be transferred to industry, facilitating smart information use. Further economic benefits are realized through the training and development of expertise in high-performance parallel computing, promoting an innovation culture and economy. The opportunity for young Australian Honours and Postgraduate students to work at the forefront of nuclear and particle theory is an obvious social benefit.
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The formation of negative ions and neutrals in the gas phase. Structure, reactivity and mechanism. Mass spectrometry is an analytical technique used to provide information concerning the structure of a chemical compound: it is particularly useful when dealing with small amounts of biologically important molecules. It is also a facility in which charged species can be converted into transient neutrals. This project will (i) produce information about negative ion fragmentations in order to extend ....The formation of negative ions and neutrals in the gas phase. Structure, reactivity and mechanism. Mass spectrometry is an analytical technique used to provide information concerning the structure of a chemical compound: it is particularly useful when dealing with small amounts of biologically important molecules. It is also a facility in which charged species can be converted into transient neutrals. This project will (i) produce information about negative ion fragmentations in order to extend the applicability of analytical negative-ion mass spectrometry, (ii) form neutral molecules and related species which are found in stellar dust clouds and investigate their chemistry, and (iii) train graduates in ion chemistry to the highest international standards.Read moreRead less
Cumulenes and Heterocumulenes - Stellar Molecules and New Materials. This project involves the formation and characterisation of transient neutrals (formed in the mass spectrometer by neutralisation of charged precursor ions) which are either found in stellar dust clouds, or related molecules which may be either potential stellar molecules or have importance in the development of new materials. This work may lead to a better understanding of how biomolecules are formed in interstellar environs. ....Cumulenes and Heterocumulenes - Stellar Molecules and New Materials. This project involves the formation and characterisation of transient neutrals (formed in the mass spectrometer by neutralisation of charged precursor ions) which are either found in stellar dust clouds, or related molecules which may be either potential stellar molecules or have importance in the development of new materials. This work may lead to a better understanding of how biomolecules are formed in interstellar environs. The Adelaide and Berlin groups are internationally known, already with ongoing collaboration. This application seeks to extend the scope of this world-class research, and to train the premier graduate students in astrochemistry.Read moreRead less
Very high energy gamma-ray astronomy in Australia and the development of future gamma-ray detectors. Australia contributes to the burgeoning field of ground-based gamma-ray astronomy via its involvement in the CANGAROO-III project.
I will continue the development of CANGAROO-III and establish links with the other collaborations in this field, in particular H.E.S.S., also in the southern hemisphere. Studies with CANGAROO-III of high energy gamma-ray sources such as supernova remnants and active ....Very high energy gamma-ray astronomy in Australia and the development of future gamma-ray detectors. Australia contributes to the burgeoning field of ground-based gamma-ray astronomy via its involvement in the CANGAROO-III project.
I will continue the development of CANGAROO-III and establish links with the other collaborations in this field, in particular H.E.S.S., also in the southern hemisphere. Studies with CANGAROO-III of high energy gamma-ray sources such as supernova remnants and active galaxies will finally reveal the type of particles that are accelerated in such violent regions of our universe. The development of future ground-based gamma-ray detectors beyond CANGAROO-III is also a project aim, and will expand the energy coverage of gamma-ray detectors into uncharted territory.Read moreRead less
Collision data for lighting industry and plasma modeling. The project's primary aim is to progress the design of more efficient
and environmentally friendly light sources. Given the number of light
sources in use worldwide even a small improvement in the efficiency
could lead to enormous benefits to society via reduction of energy
consumption. Design of new mercury-free light sources will eliminate a
major neuro-toxin pollution source. Collaboration with research groups
at the OSRAM-SYLVA ....Collision data for lighting industry and plasma modeling. The project's primary aim is to progress the design of more efficient
and environmentally friendly light sources. Given the number of light
sources in use worldwide even a small improvement in the efficiency
could lead to enormous benefits to society via reduction of energy
consumption. Design of new mercury-free light sources will eliminate a
major neuro-toxin pollution source. Collaboration with research groups
at the OSRAM-SYLVANIA Corporation (USA) and Sheffield University (UK)
will herald the beginning of industrial application for our successful
atomic collisions research program. The previous substantial ARC
investment towards this fundamental science program has now enabled
practical application.Read moreRead less
The Quest for Ultimate Measurement Precision. Precision measurement is the foundation upon which modern technological society is built. The highest quality measurement devices rely on stable clocks for their operation. The group's existing research has been aimed at developing some of the world's most precise measurement tools based on clocks and lasers. In parallel with this, other scientists have developed the means for exquisite control of light on the microscopic scale. By combining these tw ....The Quest for Ultimate Measurement Precision. Precision measurement is the foundation upon which modern technological society is built. The highest quality measurement devices rely on stable clocks for their operation. The group's existing research has been aimed at developing some of the world's most precise measurement tools based on clocks and lasers. In parallel with this, other scientists have developed the means for exquisite control of light on the microscopic scale. By combining these two technologies, both of which lie at the extreme limit of precision, the group will develop a new generation of technology for fundamental science objectives as well as for industrial needs.Read moreRead less