Novel Fermion Actions for Lattice Gauge Theory. The Standard Model of the universe is founded on quantum field theories in which gauge bosons mediate the forces between fermions, the constituents of matter. For example, the gluon of Quantum Chromodynamics (QCD) mediates the strong interactions between quarks as they compose protons, and neutrons. The only way to reveal the long-distance properties of this fundamental gauge theory from first principles is to numerically simulate the theory on a s ....Novel Fermion Actions for Lattice Gauge Theory. The Standard Model of the universe is founded on quantum field theories in which gauge bosons mediate the forces between fermions, the constituents of matter. For example, the gluon of Quantum Chromodynamics (QCD) mediates the strong interactions between quarks as they compose protons, and neutrons. The only way to reveal the long-distance properties of this fundamental gauge theory from first principles is to numerically simulate the theory on a space-time lattice. Simulating fermions on a lattice has proved very challenging. This project will explore novel and innovative improved fermion algorithms for the general problem of gauge theories on the lattice.Read moreRead less
Novel Mass Spectrometric Approaches to the Study of Protein-Protein Interactions. Protein-protein interactions mediate all fundamental cellular processes, yet the structural complexity of protein assemblies mean they are often difficult to characterise using traditional analytical methods. This project will develop and demonstrate novel mass spectrometric approaches towards a molecular level description of the structure and interactions of biological protein complexes, which in turn may underpi ....Novel Mass Spectrometric Approaches to the Study of Protein-Protein Interactions. Protein-protein interactions mediate all fundamental cellular processes, yet the structural complexity of protein assemblies mean they are often difficult to characterise using traditional analytical methods. This project will develop and demonstrate novel mass spectrometric approaches towards a molecular level description of the structure and interactions of biological protein complexes, which in turn may underpin the rational design of drugs for the treatment of a range of human health conditions. This project will also provide training of young researchers to the highest international standards in mass spectrometry and protein science, for benefit to Australian industry and research.Read moreRead less
Negative ion mass spectrometry: fundamentals and applied applications. 1. We seek to establish negative ion mass spectrometry as a major technological tool for the sequencing of peptides and proteins. In this context, we will investigate the structures and modes of action of peptide complexes which may be of importance for the treatment and control of heart disease and stroke.
2. Negative ions of known structure will be converted (in the mass spectrometer) into transient (and reactive) molecule ....Negative ion mass spectrometry: fundamentals and applied applications. 1. We seek to establish negative ion mass spectrometry as a major technological tool for the sequencing of peptides and proteins. In this context, we will investigate the structures and modes of action of peptide complexes which may be of importance for the treatment and control of heart disease and stroke.
2. Negative ions of known structure will be converted (in the mass spectrometer) into transient (and reactive) molecules which are present in interstellar ice and dust clouds. The structures and chemistry of such molecules are of importance in understanding the origins of life on this planet.Read moreRead less
Systematically model the large-scale complexity of turbulent floods and thin film flows. This project continues development of new models, and computer
simulation, of turbulent flood, river and estuarine flow. The models
will be based systematically upon established turbulence models to
resolve accurately the complex physical processes. The development of
new and robust computer models for thin layers of coating fluid will
aid many industrial processes. We also aim to provide correct ini ....Systematically model the large-scale complexity of turbulent floods and thin film flows. This project continues development of new models, and computer
simulation, of turbulent flood, river and estuarine flow. The models
will be based systematically upon established turbulence models to
resolve accurately the complex physical processes. The development of
new and robust computer models for thin layers of coating fluid will
aid many industrial processes. We also aim to provide correct initial
conditions and boundary conditions for simpler cases of the above
flows. The approach leads to a greater understanding of the range of
applicability of the models through better estimating the errors in the
modelling process. The project develops a fundamental enabling
methodology for engineering and the sciences.
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Effective and accurate model dynamics, deterministic and stochastic, across multiple space and time scales. A persistent feature of complex systems in engineering and science is the emergence of macroscopic, coarse grained, coherent behaviour from the interactions of microscopic agents (molecules, cells, grains) and with their environment. In current modeling, ranging from ecology to materials science, the underlying microscopic mechanisms are often known, but the closures to translate microscal ....Effective and accurate model dynamics, deterministic and stochastic, across multiple space and time scales. A persistent feature of complex systems in engineering and science is the emergence of macroscopic, coarse grained, coherent behaviour from the interactions of microscopic agents (molecules, cells, grains) and with their environment. In current modeling, ranging from ecology to materials science, the underlying microscopic mechanisms are often known, but the closures to translate microscale knowledge to a system level macroscopic description are rarely available in closed form. Our novel methodology will explore this stumbling block, and promises to radically change the modeling, exploration and understanding of multiscale complex system behaviour.Read moreRead less
Special Research Initiatives - Grant ID: SR0354716
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Energetically Open Systems Research Network Study. Conceptual frameworks arising in the physical sciences, such as non-equilibrium statistical mechanics and thermodynamics, synergetics, chaos and dynamical systems theory, are seminal in the emerging science of complexity. This study will lay the groundwork for a network to link Australian and overseas research on these fundamental concepts, and their application within the context of entropy-producing systems vital to the long-term sustainabilit ....Energetically Open Systems Research Network Study. Conceptual frameworks arising in the physical sciences, such as non-equilibrium statistical mechanics and thermodynamics, synergetics, chaos and dynamical systems theory, are seminal in the emerging science of complexity. This study will lay the groundwork for a network to link Australian and overseas research on these fundamental concepts, and their application within the context of entropy-producing systems vital to the long-term sustainability of the earth - oceans, atmosphere, biosphere, CO2-free energy production, space and solar environment. The network would facilitate the development of young investigators and be linked into wider complex systems networks such as the CSIRO Centre for Complex Systems Science.Read moreRead less
The formation of negative ions and neutrals in the gas phase. Structure, reactivity and mechanism. Mass spectrometry is an analytical technique used to provide information concerning the structure of a chemical compound: it is particularly useful when dealing with small amounts of biologically important molecules. It is also a facility in which charged species can be converted into transient neutrals. This project will (i) produce information about negative ion fragmentations in order to extend ....The formation of negative ions and neutrals in the gas phase. Structure, reactivity and mechanism. Mass spectrometry is an analytical technique used to provide information concerning the structure of a chemical compound: it is particularly useful when dealing with small amounts of biologically important molecules. It is also a facility in which charged species can be converted into transient neutrals. This project will (i) produce information about negative ion fragmentations in order to extend the applicability of analytical negative-ion mass spectrometry, (ii) form neutral molecules and related species which are found in stellar dust clouds and investigate their chemistry, and (iii) train graduates in ion chemistry to the highest international standards.Read moreRead less
Cumulenes and Heterocumulenes - Stellar Molecules and New Materials. This project involves the formation and characterisation of transient neutrals (formed in the mass spectrometer by neutralisation of charged precursor ions) which are either found in stellar dust clouds, or related molecules which may be either potential stellar molecules or have importance in the development of new materials. This work may lead to a better understanding of how biomolecules are formed in interstellar environs. ....Cumulenes and Heterocumulenes - Stellar Molecules and New Materials. This project involves the formation and characterisation of transient neutrals (formed in the mass spectrometer by neutralisation of charged precursor ions) which are either found in stellar dust clouds, or related molecules which may be either potential stellar molecules or have importance in the development of new materials. This work may lead to a better understanding of how biomolecules are formed in interstellar environs. The Adelaide and Berlin groups are internationally known, already with ongoing collaboration. This application seeks to extend the scope of this world-class research, and to train the premier graduate students in astrochemistry.Read moreRead less
Negative ion mass spectrometry: fundamental studies and applied applications. We seek to:
(i) establish negative ion mass spectrometry as an analytical tool for the sequencing of proteins and to probe the structures of active peptide Ca2+ calmodulin complexes which, for example, inhibit the formation of NO from nitric oxide synthases. Controlling the concentration of nitric oxide may assist with the treatment of inflammatory and cardiac diseases, stroke and diseases of the central nervous syst ....Negative ion mass spectrometry: fundamental studies and applied applications. We seek to:
(i) establish negative ion mass spectrometry as an analytical tool for the sequencing of proteins and to probe the structures of active peptide Ca2+ calmodulin complexes which, for example, inhibit the formation of NO from nitric oxide synthases. Controlling the concentration of nitric oxide may assist with the treatment of inflammatory and cardiac diseases, stroke and diseases of the central nervous system.
(ii) to study the possibility of the formation of biological molecules of life in interstellar regions
(iii) to train graduate students to international standards in the chemistry of proteomics.Read moreRead less
Light-matter interactions using optical fibres. This program will allow Australia to build on established excellence in photonics to extend the impact of optical fibres beyond telecommunications to applications throughout the sciences. Pioneering work on materials and structures will form a platform technology enabling innovations in areas as diverse as water quality monitoring and corrosion detection. In addition, new optical fibres will be developed for the needs of the Australian Defence Forc ....Light-matter interactions using optical fibres. This program will allow Australia to build on established excellence in photonics to extend the impact of optical fibres beyond telecommunications to applications throughout the sciences. Pioneering work on materials and structures will form a platform technology enabling innovations in areas as diverse as water quality monitoring and corrosion detection. In addition, new optical fibres will be developed for the needs of the Australian Defence Force and associated industries. Fibre-based approaches to problems in biology will ultimately lead to an improved understanding of molecular structures and new tools for manipulating biomolecules.Read moreRead less