Dissecting The Pseudoexfoliation Syndrome With Complementary Genetic, Proteomic And Biophysical Strategies
Funder
National Health and Medical Research Council
Funding Amount
$490,352.00
Summary
Pseudoexfoliation syndrome (PEX) is an eye condition in which flaky material deposits in the eye, greatly increasing the risk of cataract and glaucoma which can lead to blindness. PEX is also associated with heart disease, strokes and aneurysms. Cataract surgery in PEX patients has a higher rate of complications. In this project we will determine the nature of PEX material and why it forms. This knowlege will facilitate better diagnosis and treatment of PEX preventing associated blindness.
A Genome-wide Association Study In 2000 Glaucoma Cases With Matched Controls Using Equimoloar DNA Pools
Funder
National Health and Medical Research Council
Funding Amount
$610,267.00
Summary
Glaucoma is a common cause of loss of vision worldwide but we are unable to predict which people are at high risk of blindness. We aim to discover the genetic risk factors for glaucoma. We will use cutting edge genetic technology to assess the whole genome in thousands of patients with glaucoma. We hope to identify important new glaucoma genes, which could lead to the development of diagnostic tests and treatments which will provide the most cost-efficient ways to prevent glaucoma blindness.
A Genome-wide Association Scan To Identify Genetic Risk Factors For Sight Threatening Diabetic Retinopathy
Funder
National Health and Medical Research Council
Funding Amount
$982,203.00
Summary
Diabetic eye disease is an important complication of diabetes that can lead to blindness. Very little is known about how diabetes causes eye disease, but genetics is known to play a role. We aim to identify genes that contribute to eye disease in diabetes patients. We will compare genes between patients with diabetes with and without severe diabetic eye disease using cutting edge genomic technology. We hope to be able to better predict risk of blindness and to move towards novel treatments.
Pre-blast screening of improvised explosive devices - a National counter-terrorism initiative. The proposed research is focused on the specific needs of Australian counter-terrorism interests, including those of border protection, the customs service, transport authorities, forensic laboratories, etc. The support of this proposal will ensure that Australia, and its States and Territories are protected against terrorist threats. The support provided by the collaborating organisations from the var ....Pre-blast screening of improvised explosive devices - a National counter-terrorism initiative. The proposed research is focused on the specific needs of Australian counter-terrorism interests, including those of border protection, the customs service, transport authorities, forensic laboratories, etc. The support of this proposal will ensure that Australia, and its States and Territories are protected against terrorist threats. The support provided by the collaborating organisations from the various Federal and State police and forensic agencies, and the customs service, etc, highlights the importance of this project to the nation. Finally, a PhD student and a research assistant will be involved with the project and will gain specialised skills positioning them to make strong contributions to Australia's counter-terrorism measures.Read moreRead less
Aboriginal and non-Aboriginal sex-offenders in Australia: Assessing risk for practice and policy. A key priority of Australian governments is to improve community safety through reducing the risk of sex offenders re-offending after release from prison. This project will assess the validity of tools used to predict the risk of sexual offender recidivism and identify alternate risk assessment tools for Indigenous and non-Indigenous sex offenders.
An Evaluation of Suspended Sentences of Imprisonment. A suspended sentence is a fixed term of imprisonment, the execution of which has been suspended in whole or in part. It is widely used in most Australian jurisdictions. A conflict between public and legal perceptions about the severity of this sanction contributes to a lack of public confidence in the criminal justice system and makes abolition or restrictions on the use of suspended sentences a real possibility when governments feel pressure ....An Evaluation of Suspended Sentences of Imprisonment. A suspended sentence is a fixed term of imprisonment, the execution of which has been suspended in whole or in part. It is widely used in most Australian jurisdictions. A conflict between public and legal perceptions about the severity of this sanction contributes to a lack of public confidence in the criminal justice system and makes abolition or restrictions on the use of suspended sentences a real possibility when governments feel pressured to be tough on crime. This project aims to explore the use of the suspended sentence and to evaluate its efficacy as an alternative to imprisonment.
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Visual analytics for massive multivariate networks. Visual analytics for massive multivariate networks. This project aims to create methods to visually analyse massive multivariate networks. The amount of network data available has exploded in recent years: software systems, social networks and biological systems have millions of nodes and billions of edges with multivariate attributes. Their size and complexity makes these data sets hard to exploit. More efficient ways to understand the data ar ....Visual analytics for massive multivariate networks. Visual analytics for massive multivariate networks. This project aims to create methods to visually analyse massive multivariate networks. The amount of network data available has exploded in recent years: software systems, social networks and biological systems have millions of nodes and billions of edges with multivariate attributes. Their size and complexity makes these data sets hard to exploit. More efficient ways to understand the data are needed. This project will design, implement and evaluate visualisation methods for massive multivariate network data sets. This research is expected to be used by Australian software development, biotechnology and security companies to exploit their data.Read moreRead less
Farming 4 Care: Using nature to cultivate resilience in young people. This project aims to explore how passive and active engagement with nature might influence outcomes for young people who have experienced trauma, maltreatment and disrupted families. These people are extremely vulnerable, but often slip through the system. As they rarely engage in traditional therapy, non-traditional interventions may offer a viable alternative that should be explored and harnessed for this population. In addi ....Farming 4 Care: Using nature to cultivate resilience in young people. This project aims to explore how passive and active engagement with nature might influence outcomes for young people who have experienced trauma, maltreatment and disrupted families. These people are extremely vulnerable, but often slip through the system. As they rarely engage in traditional therapy, non-traditional interventions may offer a viable alternative that should be explored and harnessed for this population. In addition, traditional interventions are delivered at enormous cost and with minimal success for this group. Using an innovative multidisciplinary design, the project plans to test four hypotheses about nature engagement to contribute to the growing field of nature-based interventions. Our approach offers an alternative that draws on existing community resources and benefits local organisations, young people and farmers.Read moreRead less
Capital Offending: Income, Work and Crime in Australia’s Convict Era. At least 60 per cent of Australia’s current prison population has been in prison before. By contrast a mere 18 per cent of transported convicts were re-incarcerated following release. This project aims to use information on the bank accounts maintained for convicts while under sentence to measure the relationship between capital formation and post-sentence marriage, migration and reconviction rates. It will look in particular ....Capital Offending: Income, Work and Crime in Australia’s Convict Era. At least 60 per cent of Australia’s current prison population has been in prison before. By contrast a mere 18 per cent of transported convicts were re-incarcerated following release. This project aims to use information on the bank accounts maintained for convicts while under sentence to measure the relationship between capital formation and post-sentence marriage, migration and reconviction rates. It will look in particular at the extent to which skills, employment opportunities and asset accumulation enabled former transported convicts to go straight. It will also result in improved archival search engines enabling access for members of the public to internationally recognised record groups hitherto held by different institutions.Read moreRead less
Rebuilding fiscal federalism in Australia: reforming the financial relationship between the Commonwealth and the States. The finances of the Australian States in the modern day face serious structural challenges. The aim of this project is to analyse and develop appropriate alternatives for reform of fiscal federalism in Australia, which would allow the States to gain access to income tax revenue as a secure source of funding in the future.