THE FIRST DEVELOPMENT OF MULTI-DIMENSIONAL SPECTRO-ELECTROCHEMISTRY AND ITS APPLICATION TO CRUCIAL TRANSFORMATIONS IN INORGANIC SYSTEMS. Electrolysis is a very widespread and efficient method of chemical synthesis both in industry and research. However, the link between the control voltage and the resultant current is often complicated and easily misinterpreted. To overcome this fundamental problem, we propose an optical spectro-electrochemistry instrument based on a two-dimensional CCD detectio ....THE FIRST DEVELOPMENT OF MULTI-DIMENSIONAL SPECTRO-ELECTROCHEMISTRY AND ITS APPLICATION TO CRUCIAL TRANSFORMATIONS IN INORGANIC SYSTEMS. Electrolysis is a very widespread and efficient method of chemical synthesis both in industry and research. However, the link between the control voltage and the resultant current is often complicated and easily misinterpreted. To overcome this fundamental problem, we propose an optical spectro-electrochemistry instrument based on a two-dimensional CCD detection array. This radically new approach enables simultaneous spectroscopic and spatial data mapping in the realm adjacent to an electrode surface. Important applications range from unequivocal identification of elusive molecules to monitoring metal corrosion. Our first objective is to elucidate certain crucial transformations of mono- and binuclear heavy metal complexes.Read moreRead less
A gold-coated magnetic nanoparticle biosensor for detecting microRNA. The project aims to develop a biosensor for detecting short sequences of RNA, called microRNA (miRNA) in blood. There are about 100 miRNA sequences that are involved in most biological processes. Changes in the levels of some miRNA sequences can serve as a biomarker for many diseases including cancers. The miRNA will be detected using gold-coated magnetic nanoparticles modified with DNA sequences complementary to the miRNA of ....A gold-coated magnetic nanoparticle biosensor for detecting microRNA. The project aims to develop a biosensor for detecting short sequences of RNA, called microRNA (miRNA) in blood. There are about 100 miRNA sequences that are involved in most biological processes. Changes in the levels of some miRNA sequences can serve as a biomarker for many diseases including cancers. The miRNA will be detected using gold-coated magnetic nanoparticles modified with DNA sequences complementary to the miRNA of interest to capture the miRNA. Application of a magnetic field allows the levels of miRNA to be detected electrochemically. The expected outcome is a commercialisable biosensor for miRNA both as a diagnostic early detection device and a prognostic device for a range of miRNA biomarkers.Read moreRead less
New strategies for characterising and monitoring protein-surface interactions: application to a biosensor for diabetic’s blood glucose regime effectiveness. This project aims to develop an antibody based biosensor for the detection of glycosylated haemoglobin (HbA1c) which serves as a marker of the effectiveness of a diabetic’s blood glucose treatment regime. Monitoring HbA1c is important as many of the long term health effects of diabetes are a consequence of high blood glucose levels. The si ....New strategies for characterising and monitoring protein-surface interactions: application to a biosensor for diabetic’s blood glucose regime effectiveness. This project aims to develop an antibody based biosensor for the detection of glycosylated haemoglobin (HbA1c) which serves as a marker of the effectiveness of a diabetic’s blood glucose treatment regime. Monitoring HbA1c is important as many of the long term health effects of diabetes are a consequence of high blood glucose levels. The simple to use technology will be a general detection strategy for proteins and hence will be applicable for the detection of a wide range of diseases and biomarkers. The research will also benefit Australia by training the new generation of scientists for Australia's biomedical diagnostics industry.Read moreRead less
Fabrication and Application of Ion-Sensors Based on the Voltammetry of Nanocrystals Adhered to Electrode Surfaces. A significant need exists for the low cost determination of cations and anions in biologically (blood, urine), industrially (process streams) and environmentally (rivers, lakes) important fluids. In this project, skills in sensor design, scientific instrumentation, materials science, electrochemistry and analytical science provided by a consortium of scientists at Monash University ....Fabrication and Application of Ion-Sensors Based on the Voltammetry of Nanocrystals Adhered to Electrode Surfaces. A significant need exists for the low cost determination of cations and anions in biologically (blood, urine), industrially (process streams) and environmentally (rivers, lakes) important fluids. In this project, skills in sensor design, scientific instrumentation, materials science, electrochemistry and analytical science provided by a consortium of scientists at Monash University, the Victorian Institute for Chemical Sciences, Oxford Biosensors and Oxford University will be integrated to fabricate and develop applications of commercially viable ion-sensing systems. The principles to be utilised are based on novel forms of voltammetry of nanocrystals adhered to electrode surfaces.Read moreRead less
Special Research Initiatives - Grant ID: SR0354560
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
AUSTRALIAN RESEARCH NETWORK IN ANALYTICAL SCIENCE (ARNAS). The initiative will provide the foundations for the establishment of an Australian Research Network in Analytical Science (ARNAS), which will bring together fundamental researchers and practitioners working in quantitative chemical analysis and related areas. ARNAS will provide national coordination of research in analytical science, coverage of the newest developments, pooling of expertise and research facilities and resources, and rap ....AUSTRALIAN RESEARCH NETWORK IN ANALYTICAL SCIENCE (ARNAS). The initiative will provide the foundations for the establishment of an Australian Research Network in Analytical Science (ARNAS), which will bring together fundamental researchers and practitioners working in quantitative chemical analysis and related areas. ARNAS will provide national coordination of research in analytical science, coverage of the newest developments, pooling of expertise and research facilities and resources, and rapid dissemination of outcomes. ARNAS will significantly advance the national research agenda for analytical science by improving awareness of research activities and expertise, providing enhanced education and opportunities for the next generation of analytical scientists, and by stimulating new international collaborations.Read moreRead less
Solving the problem of detecting small molecules in complex samples: A Label-Free Electrochemical Immuno-biosensor for drugs and pesticides. Biosensors are portable analytical devices which can be used by the general public without specialist training. The proposed research will develop a biosensor for the detection of small molecules such as pesticides, poisons and drugs; a class of analytes where there is currently no viable biosensor technology. The simple to use device will benefit the Aus ....Solving the problem of detecting small molecules in complex samples: A Label-Free Electrochemical Immuno-biosensor for drugs and pesticides. Biosensors are portable analytical devices which can be used by the general public without specialist training. The proposed research will develop a biosensor for the detection of small molecules such as pesticides, poisons and drugs; a class of analytes where there is currently no viable biosensor technology. The simple to use device will benefit the Australian community by providing technology which will allow rapid and inexpensive monitoring of water as well as biomedical diagnosis. The research will also benefit Australia via providing the training of scientists to establish the new generation of Australia's bionanotechnology industry. Read moreRead less
Development of a Novel Photoelectrochemical Method for Ultra-sensitive and Selective Determination of Organic Pollutants. Rapidly deteriorating environmental conditions have caused worldwide fresh water shortage problems. For Australia, this is an urgent issue due to our limited fresh water resources. Globally, all levels of governments and legislative authorities have attempted to adopt stricter environmental legislation and better water resource management practice to address these urgent prob ....Development of a Novel Photoelectrochemical Method for Ultra-sensitive and Selective Determination of Organic Pollutants. Rapidly deteriorating environmental conditions have caused worldwide fresh water shortage problems. For Australia, this is an urgent issue due to our limited fresh water resources. Globally, all levels of governments and legislative authorities have attempted to adopt stricter environmental legislation and better water resource management practice to address these urgent problems. However, these priorities cannot be achieved until large scale and accurate environmental data are available. The success of the project would result in a new environmental monitoring system capable of online, real-time monitoring of environmental water quality, which will directly benefit water resource management practice in Australia. Read moreRead less
A multi-metal ion sensor for analysis of environmental water. The aim of this research project is to develop an electrochemical sensor array on a single chip for the detection of several heavy metals in wastewater samples. Each electrode in the array will be modified with a different metal-binding peptide ligand; resulting in a characteristic response pattern for a given metal ion. Deconvolution of the sensor response into the response patterns of the individual metals will be achieved using p ....A multi-metal ion sensor for analysis of environmental water. The aim of this research project is to develop an electrochemical sensor array on a single chip for the detection of several heavy metals in wastewater samples. Each electrode in the array will be modified with a different metal-binding peptide ligand; resulting in a characteristic response pattern for a given metal ion. Deconvolution of the sensor response into the response patterns of the individual metals will be achieved using pattern recognition software employing artificial neural networks and other multivariate techniques. Successful development of the multi-analyte sensor will allow the rapid monitoring of environmentally important metal ions in the field.Read moreRead less
Multi-Colour Electrogenerated Chemiluminescence. This project plans to explore a new approach to chemical detection, in which molecules that emit different coloured light can be selectively switched on or switched off via the applied electrode potential. This would enable unprecedented numbers of simultaneous (multiplexed) detection events for time-critical analytical applications such as clinical diagnostics, environmental monitoring and biodefense assays. These assays could be performed on low ....Multi-Colour Electrogenerated Chemiluminescence. This project plans to explore a new approach to chemical detection, in which molecules that emit different coloured light can be selectively switched on or switched off via the applied electrode potential. This would enable unprecedented numbers of simultaneous (multiplexed) detection events for time-critical analytical applications such as clinical diagnostics, environmental monitoring and biodefense assays. These assays could be performed on low-cost microfluidic platforms operated by portable consumer devices such as mobile phones. Expected outcomes may provide new capabilities in rapid screening for disease biomarkers, environmental pollutants and bioterrorism agents, using simple, low-cost, portable instrumentation.Read moreRead less
Nanoscale liquid interfaces: properties and molecular sensitivity. Challenges facing society in health and environment need new molecular measurements that are accurate, sensitive and fast. By use of nanoscale oil-water junctions, the project will develop new chemical and biological sensors that hold great promise for solving molecular measurement problems, including the ability to detect single molecules.