Haemodynamic investigation of flow diverter stents for the treatment of intracranial aneurysms. This project will explore the engineering of a flow diverter, an endovascular device for the treatment of brain aneurysms. The project will determine the optimal design of new types of flow diverters, which in turn could improve the effectiveness of treatments, thus reducing the associated costs of cerebral haemorrhage and stroke.
Autonomous body sensors in humans: investigating new bio-sensing techniques with self-power generation. Using advanced integrated electronic and mechanical systems, it is now possible to design small biomedical sensors that can be inserted into the body to take biological measurements. This project introduces a new kind of bio-sensors with self-energy generation capability and reduces the need for periodic battery replacement. New wireless and circuit techniques are investigated to reduce power ....Autonomous body sensors in humans: investigating new bio-sensing techniques with self-power generation. Using advanced integrated electronic and mechanical systems, it is now possible to design small biomedical sensors that can be inserted into the body to take biological measurements. This project introduces a new kind of bio-sensors with self-energy generation capability and reduces the need for periodic battery replacement. New wireless and circuit techniques are investigated to reduce power consumption and physical dimensions, while providing a better performance and a safer wireless link. The project aims to deliver high level of comfort, better mobility and better patient care.Read moreRead less
Technology platform for noninvasive measurement of intracranial pressure. The project aims to investigate a technology platform for noninvasive measurement of fluid pressure in the brain to improve assessment of brain function. Engineering approaches will aim to characterise the relationships between arterial and intracranial pressure from experimental data, computational models and signal processing of noninvasive blood pressure in the aorta, pressure in the eye and blood flow in brain and reti ....Technology platform for noninvasive measurement of intracranial pressure. The project aims to investigate a technology platform for noninvasive measurement of fluid pressure in the brain to improve assessment of brain function. Engineering approaches will aim to characterise the relationships between arterial and intracranial pressure from experimental data, computational models and signal processing of noninvasive blood pressure in the aorta, pressure in the eye and blood flow in brain and retinal vessels. Findings are expected to produce novel engineering advances in development of techniques and devices for intracranial pressure measurement, a procedure currently limited to high-risk invasive methods.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100128
Funder
Australian Research Council
Funding Amount
$670,000.00
Summary
Helium and neon ion microscope for sub nanometer imaging and fabrication. The project's proposed instrument would add a new desperately needed capability to Australia's high resolution microscopy centre and nano fabrication facility and enable a wide range of users to image, measure, build and design complex nanostructures at the atomic level and upwards.
Biological determinants of the safety and stability of neuroprosthetic stimulation electrodes. Performance of cochlear implants and the quality of sound perceived by patients is strongly related to electrode impedance. Electrode impedance fluctuates relative to the implant electrical activity, but the mechanisms which cause this are not clear. This project aims to investigate the role of protein adsorption in electrode performance, including impedance and material dissolution. To enable these in ....Biological determinants of the safety and stability of neuroprosthetic stimulation electrodes. Performance of cochlear implants and the quality of sound perceived by patients is strongly related to electrode impedance. Electrode impedance fluctuates relative to the implant electrical activity, but the mechanisms which cause this are not clear. This project aims to investigate the role of protein adsorption in electrode performance, including impedance and material dissolution. To enable these investigations a new biomimetic analogue of the perilymph (cochlea fluid) is intended to be developed. Additionally, the project aims to investigate two strategies to minimise impedance changes: small pulse electrode cleaning and antifouling coatings. Understanding and control of factors influencing electrode stability aim to facilitate next-generation implant designs.Read moreRead less
Rapid point-of-care detection of genomic variations for personalised medicine. Selecting treatment based on a person’s genetic profile can improve drug safety and efficacy, but the application is hampered by the inconvenience, slow result turnaround and high cost of current lab-based tests. Full implementation of personalised medicine in clinical practice requires a point-of-care testing system. This project aims to overcome the challenges involved in developing such a system by validating novel ....Rapid point-of-care detection of genomic variations for personalised medicine. Selecting treatment based on a person’s genetic profile can improve drug safety and efficacy, but the application is hampered by the inconvenience, slow result turnaround and high cost of current lab-based tests. Full implementation of personalised medicine in clinical practice requires a point-of-care testing system. This project aims to overcome the challenges involved in developing such a system by validating novel rapid genotyping methods and developing ultrasensitive real-time DNA detection that will be integrated on a single chip platform to facilitate a small, low cost and reliable test device. The technology will be readily adaptable to areas where prompt access to genomic information is valuable, such as disease diagnosis and risk prediction.Read moreRead less
A novel platform-technology for long-term subcutaneous neurophysiology. This project aims to develop a novel miniature device for subcutaneous and tetherless brain sensing. It addresses the lack of a device solution for brain-sensing that combines ultra-long-term reliable sensing capability and small dimensions for minimally-invasive procedures. We achieve this through our novel electrode architecture that significantly enhances the quality and reliability of recorded brain signals. We introduce ....A novel platform-technology for long-term subcutaneous neurophysiology. This project aims to develop a novel miniature device for subcutaneous and tetherless brain sensing. It addresses the lack of a device solution for brain-sensing that combines ultra-long-term reliable sensing capability and small dimensions for minimally-invasive procedures. We achieve this through our novel electrode architecture that significantly enhances the quality and reliability of recorded brain signals. We introduce a platform technology designed for subscalp anatomy with future use in various brain-machine interfacing applications relying on reliable, long-term and easy-to-implant systems. This project's device manufacturing, training, and intellectual property are expected to strengthen Australia's position in bioelectronics.Read moreRead less
Improved effectiveness of cochlear implants through new simultaneous stimulation techniques. Cochlear implants have brought the gift of hearing to 250,000 people worldwide and are an excellent example of Australian innovation. This project will examine an improved "high fidelity" stimulation strategy with the objective of defining a safe stimulus range for clinical use and providing a commercial advantage for Cochlear Ltd.
Circuit-based monitoring and characterisation of high performance semiconductor processes. As a frontier technology, this project extends Australia's leadership in wireless communications. Potentially this project provides the key enabling method for integrated circuits to take full advantage of future generations of semiconductor technology. National Research Priorities safeguarding Australia and promoting and maintaining good health will also be impacted through more capable circuits for def ....Circuit-based monitoring and characterisation of high performance semiconductor processes. As a frontier technology, this project extends Australia's leadership in wireless communications. Potentially this project provides the key enabling method for integrated circuits to take full advantage of future generations of semiconductor technology. National Research Priorities safeguarding Australia and promoting and maintaining good health will also be impacted through more capable circuits for defence electronics and anti-terrorism, medical remote sensing and networking. The innovations here will make Sapphicon, Australia's only commercial integrated circuit manufacturer, more competitive and indirectly benefit National ICT Australia (NICTA), Commonwealth Scientific and Industrial Research Organisation (CSIRO), Defence Science and Technology Organisation (DSTO), the National Broadband Network and a host of other high-performance electronics concerns.Read moreRead less
Dynamic terahertz superlenses for sub-wavelength sensing and imaging. We propose to develop a 'dynamic terahertz superlens' that will dramatically enhance the performance of existing T-ray imaging systems used for biosensing of cells, DNA and proteins. The science of the superlens is remarkable in that it enables image resolution shorter than the wavelength.