The Healthy Brain Project: A Prospective Cohort Study To Examine How Later-life University Education May Affect The Trajectory Of Ageing-related Cognitive Decline
Funder
National Health and Medical Research Council
Funding Amount
$1,085,742.00
Summary
Previous research has indicated that higher levels of education in early adulthood are associated with lower risk for dementia in older adults. This world-first project will examine if older adults who undertake university education have reduced rates of age-related cognitive decline than older adults who do not undertake further education. This would support the notion that boosting cognitive reserve in later life is protective against age- and disease-related neurodegenerative change.
Understanding climate and harvest induced changes in fish life histories. This project aims to quantify the cumulative impacts of harvest and climate change across marine fishes and ecosystems. The project expects to generate new knowledge in this area by coupling the rich biological information archived in fish ear bones, with targeted multi-generation experiments and predictive modelling. Expected outcomes include fundamental insights into how human-induced environmental change affects fish gr ....Understanding climate and harvest induced changes in fish life histories. This project aims to quantify the cumulative impacts of harvest and climate change across marine fishes and ecosystems. The project expects to generate new knowledge in this area by coupling the rich biological information archived in fish ear bones, with targeted multi-generation experiments and predictive modelling. Expected outcomes include fundamental insights into how human-induced environmental change affects fish growth and maturation, and a subsequent critical evaluation of the sensitivity of fisheries models to trends in these life-history traits. This should provide significant benefits to fisheries and ecosystem management, ensuring they remain productive and resilient in a time of rapid environmental change.Read moreRead less
Ecological-epidemiological models of feral swamp buffalo control in northern Australia. This research is locally, nationally and internationally significant because it 1) improves the capacity of the Northern Territory and its traditional aboriginal owners to manage together this prevalent species in an effort to minimise disturbance to native flora and fauna and to understand the long-term implications of continued proliferation, 2) provides a nationally relevant system to monitor and project t ....Ecological-epidemiological models of feral swamp buffalo control in northern Australia. This research is locally, nationally and internationally significant because it 1) improves the capacity of the Northern Territory and its traditional aboriginal owners to manage together this prevalent species in an effort to minimise disturbance to native flora and fauna and to understand the long-term implications of continued proliferation, 2) provides a nationally relevant system to monitor and project the spread of disease through feral animal populations in Australia, and 3) combines quantitative data and robust analytical tools that can be used as a template for solving many broad-scale feral animal problems around the world.Read moreRead less
A Game Changer? Alcohol and Women's Sport in Australia. This project aims to investigate emerging relationships between women and alcohol in Australian sport. We will examine the meanings that drinking may have for sportswomen and female fans, and identify new theoretical frameworks for rethinking drinking, gender and sport. In the context of public and policy debates about the risks and social impacts of alcohol consumption, we expect to generate significant new knowledge outcomes. These includ ....A Game Changer? Alcohol and Women's Sport in Australia. This project aims to investigate emerging relationships between women and alcohol in Australian sport. We will examine the meanings that drinking may have for sportswomen and female fans, and identify new theoretical frameworks for rethinking drinking, gender and sport. In the context of public and policy debates about the risks and social impacts of alcohol consumption, we expect to generate significant new knowledge outcomes. These include a world first research corpus of direct relevance for sports administrators and policy-makers, who are currently grappling with the costs and consequences of alcohol use in licensing and legislation, as well as in marketing, sponsorship and promotion of sport to women.Read moreRead less
The Lively Regional City: Mapping City Centre ‘Assemblages’ that Work. This project analyses city centre revitalisation processes and policies in the context of regional Australia. Working with Wollongong City Council, the project aims to provide an evidence-based analysis of how the Wollongong city centre is perceived, regarded and used by its residents and visitors, paying particular attention to those aspects considered either 'lively' or 'dead'; its goal is to interrogate revitalisation poli ....The Lively Regional City: Mapping City Centre ‘Assemblages’ that Work. This project analyses city centre revitalisation processes and policies in the context of regional Australia. Working with Wollongong City Council, the project aims to provide an evidence-based analysis of how the Wollongong city centre is perceived, regarded and used by its residents and visitors, paying particular attention to those aspects considered either 'lively' or 'dead'; its goal is to interrogate revitalisation policy frameworks and create decision-making tools to inform planning processes for long-term city centre revitalisation and sustainable economic growth; and identify opportunities for innovative city centre planning in Wollongong to contribute to the regions sustainable transformation, long-term growth, employment and community development.Read moreRead less
Effects of maternal foraging success and oceanographic variation on offspring behaviour and survival in the southern elephant seal. Juvenile survival is the key determinant of mammalian population performance, but the proximate determinants of this have rarely been established in large, long-lived predators. Southern elephant seals, with their concentrated lactation effort and marked separation of energy acquisition (at-sea foraging) and expenditure (on-land lactation) provide an ideal model for ....Effects of maternal foraging success and oceanographic variation on offspring behaviour and survival in the southern elephant seal. Juvenile survival is the key determinant of mammalian population performance, but the proximate determinants of this have rarely been established in large, long-lived predators. Southern elephant seals, with their concentrated lactation effort and marked separation of energy acquisition (at-sea foraging) and expenditure (on-land lactation) provide an ideal model for investigating these factors. In this study, we investigate the partitioning of pre-partum performance (fat acquired in mothers) relative to spatial-temporal variation in ocean productivity and the effect of this expenditure on offspring condition and survival. Here, the final missing link of energy transfer and its effects on offspring will be a major outcome of this project.Read moreRead less
Unlocking telomere effects on life, death and fitness in a warming world. Few things in biology provoke such a strong desire for understanding as when adult death and fatal disease can be predicted early in life. A common factor linking early life stress, disease, ageing and time of death are telomeres, the protective regions at the end of each chromosome. This project aims to explicitly link telomere dynamics in free-living ectotherm populations with experimental approaches to advance our under ....Unlocking telomere effects on life, death and fitness in a warming world. Few things in biology provoke such a strong desire for understanding as when adult death and fatal disease can be predicted early in life. A common factor linking early life stress, disease, ageing and time of death are telomeres, the protective regions at the end of each chromosome. This project aims to explicitly link telomere dynamics in free-living ectotherm populations with experimental approaches to advance our understanding of parental and environmental effects on offspring telomeres and their effects later in life. This project will take advantage of one of the world’s longest datasets on ectotherm responses to climate to provide new knowledge of how telomeres affect fitness and the role that the environment plays.Read moreRead less
Does mother know best? Unifying proximate causation and ultimate explanation in mammalian sex allocation. The study of parental effects is a fundamental area in evolutionary ecology, but is characterised by poor integration of theory (ultimate causation) and physiology (proximate causation). This is true in sex allocation research that focuses almost exclusively on ultimate causation without integrating the physiological mechanisms for sex ratio adjustment. Using a combination of experiments and ....Does mother know best? Unifying proximate causation and ultimate explanation in mammalian sex allocation. The study of parental effects is a fundamental area in evolutionary ecology, but is characterised by poor integration of theory (ultimate causation) and physiology (proximate causation). This is true in sex allocation research that focuses almost exclusively on ultimate causation without integrating the physiological mechanisms for sex ratio adjustment. Using a combination of experiments and modelling, the project addresses this gap in understanding mammalian sex allocation, specifically: the lack of known mechanism; the connection between proximate mechanistic explanation and adaptive fitness explanations; and, knowledge on constraints. This project argues that one mechanism, pre-implantation glucose levels, links adaptive hypotheses with proximate causation. Read moreRead less
Maternal effects and sex allocation: an integrated approach. This project will produce research of a high international standard combining a number of key fields in evolution and ecology. The team we have assembled provides a link between Australian-based researchers and leading overseas theoreticians facilitating integration between evolutionary theory and empirical research on the unique Australian fauna. Furthermore, while climate change is identified as a priority area for research, Australi ....Maternal effects and sex allocation: an integrated approach. This project will produce research of a high international standard combining a number of key fields in evolution and ecology. The team we have assembled provides a link between Australian-based researchers and leading overseas theoreticians facilitating integration between evolutionary theory and empirical research on the unique Australian fauna. Furthermore, while climate change is identified as a priority area for research, Australia typically lacks the history of long-term phenological monitoring that is required to understand climate change impacts. This project takes an important step towards addressing this shortcoming.Read moreRead less
Flexibility in the timing of parturition: the key to viviparity in lizards? Embryos of viviparous lizards usually gain adequate nutrients from yolk. Why then has placentotrophy evolved in some species, and what new opportunities has it opened up? The answer may lie in the advantages gained from flexibility in the timing of birth, made possible by supplementary transfer of storage lipids to embryos during gestation. We argue that this provides a pivotal opportunity for evolutionary divergence: so ....Flexibility in the timing of parturition: the key to viviparity in lizards? Embryos of viviparous lizards usually gain adequate nutrients from yolk. Why then has placentotrophy evolved in some species, and what new opportunities has it opened up? The answer may lie in the advantages gained from flexibility in the timing of birth, made possible by supplementary transfer of storage lipids to embryos during gestation. We argue that this provides a pivotal opportunity for evolutionary divergence: some alpine species exploit flexible parturition; other species replace optional placentotrophy with obligate transfer. Our unique experimental approach, using two well-researched clades of viviparous skinks, will result in new testable hypotheses about the evolution of viviparity.Read moreRead less