Systematic Expansion Of The Clinical Evidence Base In Opioid Prescribing For Refractory Dyspnoea At The End Of Life
Funder
National Health and Medical Research Council
Funding Amount
$414,535.00
Summary
Morphine can relieve breathlessness in the palliative setting. But many important questions remain. What is the best dose, should the dose change over time, do different medications provide the same relief, and how common is dyspnoea in the general population? This three part project will extend our knowledge to answer these questions. Population data will provide critical background to plan best care for future palliative patients distressed by breathlessness.
Plant-herbivore interactions: a model two-species system from northern Australia. The proposed research addresses a critical aspect of magpie goose ecology. Understanding the interaction between the birds and the bulbs is critical to respond effectively to past and threatened losses of important sedge habitats to sea level rise. This knowledge will inform management of the Kakadu World Heritage Site and an iconic waterfowl of great cultural and economic significance. In addition to their importa ....Plant-herbivore interactions: a model two-species system from northern Australia. The proposed research addresses a critical aspect of magpie goose ecology. Understanding the interaction between the birds and the bulbs is critical to respond effectively to past and threatened losses of important sedge habitats to sea level rise. This knowledge will inform management of the Kakadu World Heritage Site and an iconic waterfowl of great cultural and economic significance. In addition to their importance as a Gondwanan relic and sole member of the Family Anseranatidae, the species is an important food-source for Aboriginal people, and tourists travel to the Kakadu wetlands to witness huge dry season congregations.Read moreRead less
Zeroing in on food waste: Measuring, understanding and reducing food waste. By developing a socio-culturally aware public education and social marketing programme to reduce food waste behaviours, the proposal addresses the national research priority area of an environmentally sustainable Australia. Reducing food waste by just 10% would save ~$530 million worth of wasted expenditure on food and reduce food waste in landfill by ~300,000 tonnes per annum, thereby reducing the costs associated with ....Zeroing in on food waste: Measuring, understanding and reducing food waste. By developing a socio-culturally aware public education and social marketing programme to reduce food waste behaviours, the proposal addresses the national research priority area of an environmentally sustainable Australia. Reducing food waste by just 10% would save ~$530 million worth of wasted expenditure on food and reduce food waste in landfill by ~300,000 tonnes per annum, thereby reducing the costs associated with disposal and the release of harmful methane gases. The methodology refined by this project to understand food waste will provide the basis for efficient and sustainable food waste reduction strategies and provide an approach that can be generalised to other waste streams with strong socio-cultural determinants.Read moreRead less
Native fish stocking of rivers: discriminating between hatchery-reared and wild fish. Stocking of fish is widely used in attempts to restore native fish populations. Little is known of the fate of stocked fish or the effects of stocking on resident populations. We will develop and evaluate protocols for chemical marking of otoliths of hatchery-reared fish so that their source can be determined. Experimental stocking of hatchery-reared fish will be undertaken and population structure and sourc ....Native fish stocking of rivers: discriminating between hatchery-reared and wild fish. Stocking of fish is widely used in attempts to restore native fish populations. Little is known of the fate of stocked fish or the effects of stocking on resident populations. We will develop and evaluate protocols for chemical marking of otoliths of hatchery-reared fish so that their source can be determined. Experimental stocking of hatchery-reared fish will be undertaken and population structure and source of stocked versus wild fish determined in stocked and unstocked rivers. Natural chemical signatures will also help determine important recruitment areas. The outcomes will allow fisheries managers to make informed decisions regarding stocking strategies.Read moreRead less
Why do only some exotics become invasive? Combining ecological and genomic approaches to address alternative hypotheses in a recent Australian weed. This project will specifically test alternative hypotheses about how weeds become invasive. As invasive weeds affect both agricultural and native ecosystems equally, research on understanding the mechanisms of weed invasion is critical. Outcomes will benefit Australia by allowing better prioritisation of management against exotic plants already i ....Why do only some exotics become invasive? Combining ecological and genomic approaches to address alternative hypotheses in a recent Australian weed. This project will specifically test alternative hypotheses about how weeds become invasive. As invasive weeds affect both agricultural and native ecosystems equally, research on understanding the mechanisms of weed invasion is critical. Outcomes will benefit Australia by allowing better prioritisation of management against exotic plants already in the country by providing predictive tools to estimate likelihood of spread. For formal Pest Risk Analysis by regulators (eg Biosecurity Australia), our project will provide genomic tools by which the potential weediness of a regulated plant can be assessed through genetic screening, and forms part of an international effort to identify 'weedy genes'. Read moreRead less
Development Of Diagnostic Tools To Characterise Predictors Of Therapeutic Outcome In Severe Constipation
Funder
National Health and Medical Research Council
Funding Amount
$433,999.00
Summary
This project will use fibre-optic technology to create detailed high resolution maps of colonic motor patterns in both health and in patients with severe constipation. The data will be used in combination with actual patient symptoms to help identify specific markers of disease that can differentiate sub-types of constipation and ultimately guide and improve treatment in constipated patients
The Adelaide Hills Face Zone: Reconstructing the cultural landscape and the identification of sites of cultural significance. Aim is to document historical cultural impacts on the landscape of the Adelaide Hills Face Zone, to identify and document sites of cultural heritage significance and to develop selected sites as cultural tourism destinations.The study will test developing methodologies for the interpretation of cultural landscapes with potential to pioneer the application of cultural heri ....The Adelaide Hills Face Zone: Reconstructing the cultural landscape and the identification of sites of cultural significance. Aim is to document historical cultural impacts on the landscape of the Adelaide Hills Face Zone, to identify and document sites of cultural heritage significance and to develop selected sites as cultural tourism destinations.The study will test developing methodologies for the interpretation of cultural landscapes with potential to pioneer the application of cultural heritage management strategies to a broad landscape. University departments and industry groups from diverse backgrounds will collaborate to develop management strategies and cultural tourism opportunities in a significant landscape. Outcomes will include improved planning strategies and new economic opportunities for semi-rural and rural communities.Read moreRead less
The puzzle of Metazoan life history evolution: are feeding larvae always primitive? Most marine animals have a complex life-cycles with alternating pelagic larvae and benthic adults. An theory about animal life-history evolution states that feeding larvae are always primitive and larval feeding is lost but not gained. This hypothesis is based in part on studies on the 'classical' trochophore of marine worms such as Serpulidae, a group with both feeding and non-feeding larvae. We intend to establ ....The puzzle of Metazoan life history evolution: are feeding larvae always primitive? Most marine animals have a complex life-cycles with alternating pelagic larvae and benthic adults. An theory about animal life-history evolution states that feeding larvae are always primitive and larval feeding is lost but not gained. This hypothesis is based in part on studies on the 'classical' trochophore of marine worms such as Serpulidae, a group with both feeding and non-feeding larvae. We intend to establish a detailed phylogeny for Serpulidae and assess the evolution of larvae in the group. If feeding larvae are shown to be secondary this will raise doubts about established theories of animal evolution.Read moreRead less
Assessment of bentonites as remediating agents for metal contaminated soils using innovative bioavailability reduction technology. The project seeks to carry out research on innovative, economically sustainable risk-based solutions (soil amendments) for metal-contaminated soils and methods for assessing the potential risk/bioavailability of soil bound metals. The work will determine factors affecting the reactivity, mobility and bioavailability of metals in Australian soils and clays and method ....Assessment of bentonites as remediating agents for metal contaminated soils using innovative bioavailability reduction technology. The project seeks to carry out research on innovative, economically sustainable risk-based solutions (soil amendments) for metal-contaminated soils and methods for assessing the potential risk/bioavailability of soil bound metals. The work will determine factors affecting the reactivity, mobility and bioavailability of metals in Australian soils and clays and methods by which these can be controlled. Remediation options, such as natural clay amendments to reduce metal bioavailability, will be assessed against in vivo and in vitro bioavailability assays in order to develop cost effective, risk-based remediation strategies and assessment protocols for urban and rural contaminated soils.Read moreRead less
The impact of globalisation on inequality in a small regional economy: South Australia 1845-1925. The impact of globalisation on income inequality is currently of great concern to many. Globalisation, however, is not a new phenomenon. This study examines the effect of global forces on wage and personal wealth inequality in South Australia in the 19th and early 20th century. While other studies have examined the impact of trade on inequality at an aggregate level, using questionable comparisons, ....The impact of globalisation on inequality in a small regional economy: South Australia 1845-1925. The impact of globalisation on income inequality is currently of great concern to many. Globalisation, however, is not a new phenomenon. This study examines the effect of global forces on wage and personal wealth inequality in South Australia in the 19th and early 20th century. While other studies have examined the impact of trade on inequality at an aggregate level, using questionable comparisons, this study represents a conceptual leap forward by directly estimating changes in income and wealth inequality, and their association with changes in wages, commodity and asset prices over an extended period in a small regional economy.Read moreRead less