Endoscopic Removal Of Lesions In The Gastrointestinal Tract
Funder
National Health and Medical Research Council
Funding Amount
$71,855.00
Summary
Barrett's oesophagus and flat colonic polyps are premalignant lesions with potential for progression to oesophageal and colorectal cancer, respectively. These cancers make up a signifiant portion of the burden of cancer disease in Australia. This research aims to improve outcomes of patients with Barrett's oesophagus and flat polyps by establishing the most appropriate treatment approach to Barrett's oesophagus, identifying risk factors that cause disease progression and by novel ways of enhanci ....Barrett's oesophagus and flat colonic polyps are premalignant lesions with potential for progression to oesophageal and colorectal cancer, respectively. These cancers make up a signifiant portion of the burden of cancer disease in Australia. This research aims to improve outcomes of patients with Barrett's oesophagus and flat polyps by establishing the most appropriate treatment approach to Barrett's oesophagus, identifying risk factors that cause disease progression and by novel ways of enhancing the technique of removal of polyps.Read moreRead less
Endoscopic Diagnosis And Therapy: The Frontier Of Minimally Invasive Patient Care.
Funder
National Health and Medical Research Council
Funding Amount
$344,644.00
Summary
Minimally invasive diagnosis and treatment is a rapidly developing field, and has potential to significantly improve patient management and health care utilization. This research will apply endoscopic innovations to diagnose and treat early oesophageal and pancreatic cancer, with the aim to improve survival and quality of life. The research will also develop capacity to treat oesophageal motility disorders with minimally invasive endoscopic resection techniques.
Efficacy Of Ablative Therapies For Barrett's Oesophagus
Funder
National Health and Medical Research Council
Funding Amount
$570,148.00
Summary
Some people with severe reflux develop Barrett's oesophagus, which puts them at high risk of developing cancer. Patients with Barrett's can be treated with various endoscopic ablation techniques, but it is not yet know if these treatments prevent the development of cancer. The aims of this work are to use molecular methods to ascertain whether the tissue that regenerates after ablation is normal, and to compare different ablation techniques.
The NanoNautilus : A Breakthrough In The Successful Treatment Of Strokes And Other Cerebrovascular Diseases
Funder
National Health and Medical Research Council
Funding Amount
$187,212.00
Summary
Strokes are one of the biggest killers of Australians and are becoming increasingly so every year. Bleeding from the brain involves extremely delicate and dangerous medical treatments. The development of NanoNautilus [TM]---a remote-controlled steerable microcatheterusing world-first miniaturization technology---will revolutionise current practises and greatly reduce the current risk with medical intervention.
Efficacy Of Coronary Sinus Ablation For The Treatment Of Atrial Fibrillation: A Randomised Controlled Study.
Funder
National Health and Medical Research Council
Funding Amount
$377,917.00
Summary
Atrial fibrillation is the most common sustained cardiac arrhythmia in the population. Left atrial catheter ablation is rapidly becoming a drug free alternative treatment for drug-resistant atrial fibrillation. The proposed study will examine whether ablation at a unique anatomical site adjacent to the left atrium (the coronary sinus) will increase procedural success compared to the conventional approach.
A Novel Nitric Oxide-based Treatment For Recalcitrant Staphylococcus Aureus-associated Chronic Rhinosinusitis
Funder
National Health and Medical Research Council
Funding Amount
$541,377.00
Summary
Chronic rhinosinusitis (CRS) is a common condition affecting the lives of up to 16% of the population. With yet no cure, the search for effective means of therapy is crucial. Patients with severe disease are most often found to have infection with the bacteria Staphylococcus aureus, associated with more severe symptoms and reduced quality of life. This study will investigate the effectiveness of a novel topical liposome-encapsulated nitric oxide in the treatment of this burdensome disease.
BEST-Australia: A Phase II Study Of Non-Endoscopic Screening For Barretts Oesophagus In Primary Care
Funder
National Health and Medical Research Council
Funding Amount
$513,481.00
Summary
Barrett's oesophagus is common in people with heartburn and may progress to oesophageal cancer. Most cases of oesophageal cancer are diagnosed at a late stage when chances of survival are poor. Currently Barrett's is only diagnosed by endoscopy. We will test how effective and acceptable a non-endoscopic sponge capsule and novel laboratory test is at detecting Barrett's oesophagus early. This could potentially enable early detection of this pre-cancerous condition in general practice.
The Role Of Calcium And TRPC Channels In Sinoatrial Node Ageing
Funder
National Health and Medical Research Council
Funding Amount
$385,301.00
Summary
The failure of pacemaker function is a common clinical problem in the elderly who become more susceptible to cardiac arrhythmias. We recently discovered a new calcium channel called the transient receptor potential canonical channel (TRPC) in the pacemaker cells. The aim of this research is to study the role of TRPC channels in pacemaker ageing. Improved understanding of the mechanisms of the pacemaker ageing may provide new therapeutic strategies for reducing the risk of cardiac arrhythmias.
Outcomes Of The Arterial Switch Operation: A Multi-centre Study
Funder
National Health and Medical Research Council
Funding Amount
$86,733.00
Summary
The arterial switch operation is the surgery of choice for children born with transposition of the great arteries, a congenital heart defect where the main two vessels of the heart arise from wrong pumping chambers of the heart. There are very few studies looking at adults after this operation. We aim to study all patients who have had an arterial switch. The results of this study will further increase our knowledge of the long term consequences of having the arterial switch operation.