Industrial Transformation Research Hubs - Grant ID: IH180100020
Funder
Australian Research Council
Funding Amount
$3,058,152.00
Summary
ARC Research Hub for Integrated Energy Storage Solutions. The ARC Research Hub for Integrated Energy Storage Solutions aims to develop advanced energy storage technologies, including printed batteries, structural supercapacitors, innovative fuel cells and power-to-gas systems. It plans to integrate these storage solutions with existing energy networks and applications using novel storage monitoring, control and optimisation technologies. The Hub is expected to generate new knowledge in storage t ....ARC Research Hub for Integrated Energy Storage Solutions. The ARC Research Hub for Integrated Energy Storage Solutions aims to develop advanced energy storage technologies, including printed batteries, structural supercapacitors, innovative fuel cells and power-to-gas systems. It plans to integrate these storage solutions with existing energy networks and applications using novel storage monitoring, control and optimisation technologies. The Hub is expected to generate new knowledge in storage technology manufacturing, control and management. Expected outcomes include cheaper and more effective storage devices and better storage integration solutions, supporting renewables, reducing carbon emissions, and improving efficiency in the energy sector. Resulting benefits include a more sustainable, secure, reliable and economically efficient energy supply. This Hub will contribute to improving the economic efficiency of Australia’s energy sector.Read moreRead less
Transforming Microgrid to Virtual Power Plant –ICT Frameworks,Tools,Control. The project aims to enhance large scale renewable penetrations to national power grid by advancing control, optimization, and ancillary services of Virtual Power Plants (VPPs), considering different disruptive events including recent South Australian blackout. This project expects to create new control, frame communication architecture, develop plug and play type IoT enabled grid interfacing inverter, and optimize resou ....Transforming Microgrid to Virtual Power Plant –ICT Frameworks,Tools,Control. The project aims to enhance large scale renewable penetrations to national power grid by advancing control, optimization, and ancillary services of Virtual Power Plants (VPPs), considering different disruptive events including recent South Australian blackout. This project expects to create new control, frame communication architecture, develop plug and play type IoT enabled grid interfacing inverter, and optimize resource management for distributed VPPs. The anticipated benefits from this institutional level collaborations are that VPPs help in enhancing national power grid operations during normal and disruptive conditions when more renewables are connected and also secure benefits of consumers, prosumers, and grid operators.Read moreRead less
Building Australia's Electric Vehicle Fast Charging Infrastructure. This project aims to enhance the resilience, safety, and efficiency of electricity grids operated with fast-charging Electric Vehicles (EVs) by developing new control and optimisation frameworks. This project expects to develop new robust controllers for EV fast-charging infrastructure operated in coordination with wind and solar generated electricity. Expected project outcomes include enabling fast-charge EV infrastructure to b ....Building Australia's Electric Vehicle Fast Charging Infrastructure. This project aims to enhance the resilience, safety, and efficiency of electricity grids operated with fast-charging Electric Vehicles (EVs) by developing new control and optimisation frameworks. This project expects to develop new robust controllers for EV fast-charging infrastructure operated in coordination with wind and solar generated electricity. Expected project outcomes include enabling fast-charge EV infrastructure to be developed and deployed in Australia by the industry partner SwitchDin. Expected benefits including enabling significant reduction in carbon emissions from the transportation sector, accelerating the energy transition to renewables, and placing Australian industry at the forefront of EV grid integration technology.Read moreRead less
Examination Of The Molecular Pharmacology Of Anthracyclines Induced Via Their Interaction With Iron
Funder
National Health and Medical Research Council
Funding Amount
$618,401.00
Summary
Anthracyclines are highly effective anti-cancer drugs, but their use is limited by toxic effects on the heart. This is thought to be due to these drugs directly binding iron (Fe). Indeed, we showed that anthracyclines induced marked changes in the way heart cells utilise Fe (DR1-3, 38; Mol. Pharmacol. 2002, 2003, 2004, 2005). We were the first to show that anthracyclines prevent Fe release from the criticial Fe storage protein ferritin. This prevents the use of Fe for vital processes eg. DNA and ....Anthracyclines are highly effective anti-cancer drugs, but their use is limited by toxic effects on the heart. This is thought to be due to these drugs directly binding iron (Fe). Indeed, we showed that anthracyclines induced marked changes in the way heart cells utilise Fe (DR1-3, 38; Mol. Pharmacol. 2002, 2003, 2004, 2005). We were the first to show that anthracyclines prevent Fe release from the criticial Fe storage protein ferritin. This prevents the use of Fe for vital processes eg. DNA and haem synthesis. Hence, this effect probably contributes to the cytotoxic activity of anthracyclines on the heart. We showed that novel drugs developed in my lab that bind Fe called chelators show high activity in animals (DR4) and prevent anthracycline-mediated Fe accumulation in ferritin. Importantly, Fe chelators have been shown to inhibit anthracycline-mediated cardiotoxicity. Indeed, the clinically used cardioprotective agent, ICRF-187, is actually an Fe chelator (5, DR6). However, ICRF-187 is not totally successful in terms of its cardioprotective effects and can cause myelosuppression (5, DR6). While the clinically used chelator, desferrioxamine (DFO), can prevent anthracycline-mediated cardiotoxicity, its poor membrane permeability limits its effectiveness. Our chelators are highly permeable and overcome the disadvantages of DFO (DR4). Thus, they are vital to examine for preventing anthracycline-mediated cardiotoxicity. In this proposal we will examine the changes in Fe metabolism induced by anthracyclines and test the hypothesis that novel Fe chelators may prevent the cardiotoxicity of these agents. We also aim to be the first to assess if preparation of anthracyclines which cannot bind iron prevents their cardiotoxicity. This will be done by preparing metal complexes of these drugs which prevent Fe-binding eg. anthracycline-zinc complexes. These studies are important for the development of less cardiotoxic forms of these very useful anti-tumour agents.Read moreRead less
Thermal transport in multi-phase flows for concentrating solar applications. This project seeks to advance the field of heat transfer in high-temperature systems involving liquid metals, with emphasis on energy storage and solar power technologies. The concept couples a tubular sodium boiler with a sodium chloride phase-change storage system for continuous energy supply. Sodium chloride is low cost and has a melting temperature suitable for a wide range of industrial processes. The project plans ....Thermal transport in multi-phase flows for concentrating solar applications. This project seeks to advance the field of heat transfer in high-temperature systems involving liquid metals, with emphasis on energy storage and solar power technologies. The concept couples a tubular sodium boiler with a sodium chloride phase-change storage system for continuous energy supply. Sodium chloride is low cost and has a melting temperature suitable for a wide range of industrial processes. The project plans to address the challenge of sodium stability in highly irradiated tubes by investigating mass, momentum, energy and radiative transport in liquid metals. It is intended that this will inform the design and testing of novel sodium boilers to provide stable and isothermal process heat for continuous or on-demand production of power, chemical fuels and commodities.Read moreRead less
Hydrogen generation by subsurface iron mineral transformations. Aim
The aim of this project is to elucidate key factors responsible for natural hydrogen generation in Australian subsurface environments.
Significance
Large amounts of this valuable resource are produced naturally with estimates of production rates of this “gold” hydrogen at least 100 times the annual demand for this critical resource.
Expected Outcomes
Based on improved understanding of the source of natural hydrogen, predictive ....Hydrogen generation by subsurface iron mineral transformations. Aim
The aim of this project is to elucidate key factors responsible for natural hydrogen generation in Australian subsurface environments.
Significance
Large amounts of this valuable resource are produced naturally with estimates of production rates of this “gold” hydrogen at least 100 times the annual demand for this critical resource.
Expected Outcomes
Based on improved understanding of the source of natural hydrogen, predictive tools will be developed that will assist in assessing the viability in Australia of hydrogen exploration and engineered retrieval.
Benefits
Ready access to naturally produced hydrogen could enable Australia to replace hydrogen that is currently generated via the use of unabated hydrocarbons.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC210100021
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Training Centre in Energy Technologies for Future Grids. The proposed Future Grids Training Centre will advance Australia’s transition to a clean energy future. It will address the complex and challenging issues currently limiting the growth of renewable energy through innovations that facilitate widespread integration of these resources into electricity grids while maintaining grid stability. The Centre will deliver the next generation of industry leaders and specialists in future grid tech ....ARC Training Centre in Energy Technologies for Future Grids. The proposed Future Grids Training Centre will advance Australia’s transition to a clean energy future. It will address the complex and challenging issues currently limiting the growth of renewable energy through innovations that facilitate widespread integration of these resources into electricity grids while maintaining grid stability. The Centre will deliver the next generation of industry leaders and specialists in future grid technologies for renewable energy generation, transmission and distribution, supported by renewable hydrogen energy storage and market driven customer responsiveness enabled by new information and communications technologies, to provide a more sustainable, reliable, secure and affordable electricity system.Read moreRead less
Multifunctional trilayer separator for durable multivalent energy storage. This project aims to develop an important new family of economical, high energy, multivalent batteries based on an abundant element, sulphur. The project plans to design a new battery separator to enable long-term stability in sulphur-based rechargeable batteries. This type of separator is of critical importance in many membrane-involved energy storage technologies. The project plans to use leading-edge durable energy tec ....Multifunctional trilayer separator for durable multivalent energy storage. This project aims to develop an important new family of economical, high energy, multivalent batteries based on an abundant element, sulphur. The project plans to design a new battery separator to enable long-term stability in sulphur-based rechargeable batteries. This type of separator is of critical importance in many membrane-involved energy storage technologies. The project plans to use leading-edge durable energy technologies to strengthen the development of residential energy systems and the involvement of renewable energy sources in modern grid.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220101113
Funder
Australian Research Council
Funding Amount
$428,000.00
Summary
Optimal reaction pathways towards advanced energy technology. This project aims to develop a novel lithium-ion battery (LIB) system that delivers high energy-density, a long cycle life, low-cost, and high safety based on conversion-type lithium oxide cathodes. Expected outcomes of this project will address the preliminary challenges for the practical use of lithium-oxide, which requires innovative designs of reaction pathways to lithium oxide cathode and lithium metal anode architectures as well ....Optimal reaction pathways towards advanced energy technology. This project aims to develop a novel lithium-ion battery (LIB) system that delivers high energy-density, a long cycle life, low-cost, and high safety based on conversion-type lithium oxide cathodes. Expected outcomes of this project will address the preliminary challenges for the practical use of lithium-oxide, which requires innovative designs of reaction pathways to lithium oxide cathode and lithium metal anode architectures as well as a fundamental in-depth understanding of the electrochemical and growing mechanisms. This project will establish a manufacturing road-map for a novel lithium-ion battery system in Australia with practical reliability by integrating active lithium oxide cathode, optimized electrolyte, and lithium metal anode.Read moreRead less
Mitochondrial Iron Overload And Friedreich's Ataxia: The Role Of Frataxin In Iron And Haem Metabolism
Funder
National Health and Medical Research Council
Funding Amount
$285,990.00
Summary
Friedreich's ataxia (FA) is due to the lack of a protein known as frataxin. Recent studies using Baker's yeast have shown that the deletion of frataxin results in the accumulation of toxic iron in the mitochondrion. More recently, a variety of studies have shown that FA patients have iron loading within their cells. The iron build-up may cause severe damage. At present, the role of frataxin in mammalian mitochondrial iron metabolism is unknown. Our preliminary studies demonstrate that frataxin i ....Friedreich's ataxia (FA) is due to the lack of a protein known as frataxin. Recent studies using Baker's yeast have shown that the deletion of frataxin results in the accumulation of toxic iron in the mitochondrion. More recently, a variety of studies have shown that FA patients have iron loading within their cells. The iron build-up may cause severe damage. At present, the role of frataxin in mammalian mitochondrial iron metabolism is unknown. Our preliminary studies demonstrate that frataxin is down-regulated by either erythroid differentiation or the haem precursor protoporphyrin IX (Becker and Richardson, submitted). These data strongly suggest a role for frataxin in iron metabolism. In the present study we will continue to assess if frataxin plays a role in the way cells handle iron. Using a unique model of mitochondrial iron overload developed in my lab (Richardson et al. (1996) BLOOD 87:3477), we will extensively investigate the iron metabolism of the mitochondrion in order to determine the function of frataxin and its role in Friedreich's ataxia. In addition, we have developed a series of new drugs known as iron chelators that can enter the mitochondrion due to their high lipid solubility (Becker and Richardson 1999 J. Lab. Clin. Med. 134:510). These latter drugs are far more effective than the chelator currently used to treat iron overload, desferrioxamine (DFO). Indeed, our chelators have been designed to result in high iron chelation efficacy but low toxicity (see Becker and Richardson, 1999). This exciting research may be crucial in understanding the development of FA and in creating new therapies such as the use of iron chelators.Read moreRead less