Fundamental study of fracture-controlled compensation grouting for ground movement. This project aims to investigate the fundamentals of fracture-controlled compensation grouting in various types of soil, so as to optimise the compensation efficiency and to minimise the risk of collapse of nearby structures. This will result in the minimisation of ground movements induced by underground excavations, which pose a major threat to existing infrastructure and communities worldwide. Small-scale labor ....Fundamental study of fracture-controlled compensation grouting for ground movement. This project aims to investigate the fundamentals of fracture-controlled compensation grouting in various types of soil, so as to optimise the compensation efficiency and to minimise the risk of collapse of nearby structures. This will result in the minimisation of ground movements induced by underground excavations, which pose a major threat to existing infrastructure and communities worldwide. Small-scale laboratory experiments, centrifuge tests and numerical analyses will be conducted to develop an effective and economical grouting method that will provide a valuable design tool for engineers.Read moreRead less
Adaptive structural systems for high-performance buildings. This project aims to develop adaptive structural systems for high-performance buildings. A new theoretical platform will be instrumental in the development of building technologies such as adaptive shading and ventilation components. In a reversal of the conventional design avoidance of structural phenomena such as lateral and flexural-torsional buckling, these phenomena will be exploited to achieve functional forms for shading componen ....Adaptive structural systems for high-performance buildings. This project aims to develop adaptive structural systems for high-performance buildings. A new theoretical platform will be instrumental in the development of building technologies such as adaptive shading and ventilation components. In a reversal of the conventional design avoidance of structural phenomena such as lateral and flexural-torsional buckling, these phenomena will be exploited to achieve functional forms for shading components. Thin-metal ventilation ducts will be embedded within structural components to produce optimised ventilation strategies and to increase thermal mass, while accounting for their structural contribution.Read moreRead less
Modelling and simulation of complex granular flows. Granular flows are of crucial importance in a wide range of problems related to civil infrastructure. These include landslides and similar catastrophic events, often leading to loss of life and property. The project aims to develop new methods for accurate prediction of such events thus allowing for the formulation of efficient mitigation strategies.
Minimally invasive monitoring of sleep for disease management. Sleep, diet and exercise are the three pillars of wellbeing with poor sleep associated with medical issues such as obesity and congestive heart failure. This project will advance sleep analysis by researching new ways of monitoring that are highly accurate and convenient, enabling physicians to improve the monitoring of significant health issues.
Variational multiscale modelling of granular materials. Granular materials play an important role in a wide-range of problems related to physical infrastructure. These include landslides and similar catastrophic events often leading to loss of life and property. This project will aim to develop new methods for adequate simulation of granular flows to allow formulation of efficient risk mitigation strategies.
Harnessing the bioactivity of proteins and polypeptides: understanding and controlling adsorption processes to optimise linker free immobilisation. This project will use physical techniques and simulations to understand the interactions of biomolecules and plasma activated surfaces, allowing control of the biomolecule layer composition, orientation and conformation. This control, together with the ability of these surfaces to "lock-in" the optimised layer, will create a new generation of biodevi ....Harnessing the bioactivity of proteins and polypeptides: understanding and controlling adsorption processes to optimise linker free immobilisation. This project will use physical techniques and simulations to understand the interactions of biomolecules and plasma activated surfaces, allowing control of the biomolecule layer composition, orientation and conformation. This control, together with the ability of these surfaces to "lock-in" the optimised layer, will create a new generation of biodevices.Read moreRead less
Inventiveness and the progress of product innovation. Quantitative models of inventiveness will be used to forecast the potential rate of improvement of a technology and to re-design products to improve more rapidly and steadily. By focusing on innovation in products and technologies in energy conversion, this research can guide development funding for low-carbon energy generation.
Beyond Spectral Detection: Engineering SUPER Dot Probes for High-Throughput Discovery. Molecules that are altered as a result of a pathological condition are generally present in very low abundance, and pose a “needle-in-a-haystack” problem. Current detection, quantification and localisation technologies use fluorescent probes that are limited by sensitivity and analysis time. This project will develop a new generation of nanophotonic luminescent probes (Strong Upconversion Photo-stable Encoded ....Beyond Spectral Detection: Engineering SUPER Dot Probes for High-Throughput Discovery. Molecules that are altered as a result of a pathological condition are generally present in very low abundance, and pose a “needle-in-a-haystack” problem. Current detection, quantification and localisation technologies use fluorescent probes that are limited by sensitivity and analysis time. This project will develop a new generation of nanophotonic luminescent probes (Strong Upconversion Photo-stable Encoded nano-Radiators (SUPER) Dots), based on purpose-engineered up-conversion nanocrystals that are ultra-bright and have low background interference, high specificity, speed, and large-scale multiplexing capacity. These probes will allow microscopy and flow cytometry to measure hitherto undetectable rare-event molecules and cells, opening new frontiers for the discovery of new biomarkers.Read moreRead less
Integrated Nanoplatform for Multiomics Analysis of Cell-to-Cell Interaction. This project aims to develop an integrated nanoplatform for analysis of exosomes produced by host-pathogen interaction at the single cell level. This will be accomplished by engineering an innovative device involving plasmonic nanoparticles to probe exosomes molecular profiles over time. The intended outcome is a generic and robust platform for detailed molecular analysis of the consequences of cell-to-cell interactions ....Integrated Nanoplatform for Multiomics Analysis of Cell-to-Cell Interaction. This project aims to develop an integrated nanoplatform for analysis of exosomes produced by host-pathogen interaction at the single cell level. This will be accomplished by engineering an innovative device involving plasmonic nanoparticles to probe exosomes molecular profiles over time. The intended outcome is a generic and robust platform for detailed molecular analysis of the consequences of cell-to-cell interactions. Single cell scale will greatly improve detection accuracy for heterogeneous cell populations. Benefits will include new knowledge of cell-to-cell communication and intellectual property in manufacturing, which will foster collaborations across institutions and Australian industry by providing new technological solutions.Read moreRead less
Mapping dynamic lipid biochemistry with high spatial and molecular detail. Lipids are a complex and underappreciated family of molecules playing important roles in all of our tissues and cells. Yet, our fundamental knowledge of lipids is limited by current technology. This project aims to develop an innovative mass spectrometry imaging platform allowing lipid biochemistry to be visualised at a level of detail not before possible. This will push boundaries in molecular imaging technology and is e ....Mapping dynamic lipid biochemistry with high spatial and molecular detail. Lipids are a complex and underappreciated family of molecules playing important roles in all of our tissues and cells. Yet, our fundamental knowledge of lipids is limited by current technology. This project aims to develop an innovative mass spectrometry imaging platform allowing lipid biochemistry to be visualised at a level of detail not before possible. This will push boundaries in molecular imaging technology and is expected to provide new fundamental knowledge about the structure, function and distributions of lipids in tissues and cells. Significant benefits should include providing new tools to unravel the functions and modifications of lipids in biology, that can be extended to many other research and industrial applications. Read moreRead less