Engineering Pore Forming Proteins as machines for the delivery of proteins and nanoparticles into cells. This cross disciplinary project will revolutionise our ability to build pore forming nano-machines that specifically deliver complex macromolecules to the cell cytoplasm. The ability to efficiently deliver molecules such as antibodies and nanoparticles to the correct cell population will have enormous therapeutic application. Further, such delivery devices will have revolutionary technologica ....Engineering Pore Forming Proteins as machines for the delivery of proteins and nanoparticles into cells. This cross disciplinary project will revolutionise our ability to build pore forming nano-machines that specifically deliver complex macromolecules to the cell cytoplasm. The ability to efficiently deliver molecules such as antibodies and nanoparticles to the correct cell population will have enormous therapeutic application. Further, such delivery devices will have revolutionary technological potential as commercially relevant research tools.Read moreRead less
Space Science and Astronomy: Dissecting the Galaxy with High Resolution Multi-Object Echelle Spectrograph (HERMES) II: Decisive Observations. Australia has long been a world leader in wide-field astronomical surveys, and the new High Resolution Multi-Object Echelle Spectrograph (HERMES) being built for the Anglo-Australian Telescope (AAT) will enhance that leadership position. Through a combination of Australian technological and scientific advances, the surveys we conduct with HERMES will allow ....Space Science and Astronomy: Dissecting the Galaxy with High Resolution Multi-Object Echelle Spectrograph (HERMES) II: Decisive Observations. Australia has long been a world leader in wide-field astronomical surveys, and the new High Resolution Multi-Object Echelle Spectrograph (HERMES) being built for the Anglo-Australian Telescope (AAT) will enhance that leadership position. Through a combination of Australian technological and scientific advances, the surveys we conduct with HERMES will allow us to study galaxy formation and stellar astrophysics in unprecedented detail. There are powerful synergies between HERMES and Skymapper, another Australian astronomical survey, as well as with Gaia, the billion-dollar European space mission for studying the Galaxy; HERMES will thus promote both national and international research collaboration. In this proposal we lay the observational groundwork for maximising the scientific return from HERMES.Read moreRead less
Towards operational monitoring of key climate parameters from synthetic aperture radar. Agricultural productivity is a major contributor to the Australian economy, but is experiencing significant stress in response to climate change. Moreover, soil moisture controls vegetation dynamics that contribute to carbon storage, atmospheric processes leading to severe weather, and runoff generation processes leading to floods and runoff yield from urban water storage catchments. Consequently, high reso ....Towards operational monitoring of key climate parameters from synthetic aperture radar. Agricultural productivity is a major contributor to the Australian economy, but is experiencing significant stress in response to climate change. Moreover, soil moisture controls vegetation dynamics that contribute to carbon storage, atmospheric processes leading to severe weather, and runoff generation processes leading to floods and runoff yield from urban water storage catchments. Consequently, high resolution time-series information on soil moisture and vegetation status from space represents a powerful tool for understanding climate change impacts on Australia. It is therefore imperative that products be developed specifically for the Australian environment to take full advantage of radar data from satellites.Read moreRead less