Utilisation of dense gas technology for the development of controlled release active pharmaceutical ingredients (API) delivery systems. The aim of this project is to develop an orally administered drug formulation for the treatment of irritable bowel syndrome and other diseases of the colon. Irritable bowel syndrome is a debilitating condition and the cost to society is similar to that of asthma. As such, the project has the potential to have a major impact on society.
Bio-inspired Nanoparticles for Mechano-Regulation of Stem Cell Fate. Mechanical stimulation plays a critical role in regulating stem cell fate. Nanostructure-mediated mechanical cues can precisely stimulate stem cells, but predicting their impact on stem cell differentiation is challenging. This project aims to engineer nanostructures to regulate stem cell fate and gain a fundamental understanding of the mechanical properties that affect cell function. The expected outcomes and benefits of this ....Bio-inspired Nanoparticles for Mechano-Regulation of Stem Cell Fate. Mechanical stimulation plays a critical role in regulating stem cell fate. Nanostructure-mediated mechanical cues can precisely stimulate stem cells, but predicting their impact on stem cell differentiation is challenging. This project aims to engineer nanostructures to regulate stem cell fate and gain a fundamental understanding of the mechanical properties that affect cell function. The expected outcomes and benefits of this project include a new fundamental understanding of the effect of mechanical properties on cell function, novel insights into the regulation of stem cell fate, and the development of a new class of roughness-tunable materials suitable for use in tissue engineering and pharmaceutical applications. Read moreRead less
Photodesorption Phenomena and Photoreactive Nanosorbent Materials for Water and Wastewater Purification. Introducing more efficient production of drinking water and wastewater treatment methods for reuse is important to address increasing water scarcity in Australia. The proposed project will develop a water purification technology to remove pollutants using a recently discovered process. This process offers simple and affordable operation that is clean, robust and requires minimal attention. Th ....Photodesorption Phenomena and Photoreactive Nanosorbent Materials for Water and Wastewater Purification. Introducing more efficient production of drinking water and wastewater treatment methods for reuse is important to address increasing water scarcity in Australia. The proposed project will develop a water purification technology to remove pollutants using a recently discovered process. This process offers simple and affordable operation that is clean, robust and requires minimal attention. The technology is particularly suitable for small-scale applications in rural and remote areas, and has significant export potential. The project will strengthen established links between Australian and Korean research centres through the production of improved nanomaterials, and the development of the novel water purification technologyRead moreRead less
Nanosilver antimicrobial resistance in target pathogens. This project aims to elucidate the important phenomena of bacterial resistance to antimicrobial nanosilver, currently one of the most developed and commercialised products of nanotechnology. The integrated research approach comprises of concurrent identification of the origins and routes of nanosilver toxicity in bacteria and the arising emergence and mechanisms of bacterial defence to the toxicity. The generated knowledge is to form a bas ....Nanosilver antimicrobial resistance in target pathogens. This project aims to elucidate the important phenomena of bacterial resistance to antimicrobial nanosilver, currently one of the most developed and commercialised products of nanotechnology. The integrated research approach comprises of concurrent identification of the origins and routes of nanosilver toxicity in bacteria and the arising emergence and mechanisms of bacterial defence to the toxicity. The generated knowledge is to form a base template for novel nanosilver engineering with less tendency for resistance development and to facilitate tracking of resistance and its spread amongst microorganisms. The knowledge has far-reaching implications on the better governance of nanosilver use, including its disposal.Read moreRead less
The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling f ....The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling for a synergistic defence to adapt to the nanoparticle toxicity. The pioneering knowledge is the foundation for technologies targeting the interspecies metabolite cross-talking to overcome the resistance phenomena, ensuring a long-term efficacy of the alternative antimicrobial on the difficult-to-control pathogenic growth.Read moreRead less
Nano-scale tuning: a path to functional materials for hydrogen storage. If the nano-stores discovered can be taken from bench to markets, the way energy is produced and used will be revolutionised. New markets based on clean energy technologies will appear. The emergence of miniaturised hydrogen stores would create unforeseen markets. By utilising Australia's abundant resources in lithium (Li), magnesium (Mg) and aluminium (Al) to store hydrogen, the beneficiaries would be the Australian industr ....Nano-scale tuning: a path to functional materials for hydrogen storage. If the nano-stores discovered can be taken from bench to markets, the way energy is produced and used will be revolutionised. New markets based on clean energy technologies will appear. The emergence of miniaturised hydrogen stores would create unforeseen markets. By utilising Australia's abundant resources in lithium (Li), magnesium (Mg) and aluminium (Al) to store hydrogen, the beneficiaries would be the Australian industry and academia interested in the knowledge gained and the application of the unique features of nano-hydride materials. By reducing the emissions of greenhouse gases, society would also benefit from a cleaner environment and better health.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120102967
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Interaction between silver ions, silver nanoparticles and reactive oxygen species: implication to toxicity. The project investigates the ability of various different (supported and stabilised) types of nanosized silver particles (SNPs) to oxidatively degrade selected contaminants and or kill microorganism. The project also aims to determine the effect of solution condition (for example pH) and light on SNP longevity and hence their oxidative capacity.
Quantification of airborne engineered nanoparticles: developing a scientific framework to inform their regulation and control. Despite the presence of airborne engineered nanoparticles in many commercial/research facilities, there are no established methods for their detection/characterisation. This work aims to develop a foundation for the quantitative assessment of airborne engineered nanoparticles, which is critical for controlling exposure and minimising health risks.
Special Research Initiatives - Grant ID: SR0354656
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
Particulate Science and Technology Network. Particulate Science and Technology (PST) is a rapidly developing interdisciplinary research field concerned with particle-related phenomena at different time and length scales and represents a very significant research and development effort in Australia for many years. This network is formed by linking the world-recognized research centres/groups with different expertise. Its aim is to provide greater collaboration among the Australian and overseas re ....Particulate Science and Technology Network. Particulate Science and Technology (PST) is a rapidly developing interdisciplinary research field concerned with particle-related phenomena at different time and length scales and represents a very significant research and development effort in Australia for many years. This network is formed by linking the world-recognized research centres/groups with different expertise. Its aim is to provide greater collaboration among the Australian and overseas researchers and enhance the scale and focus of particulate research. It will help develop and maintain Australia's leading position in PST, generating massive research outcomes and training that can lead to improvement in resource, energy, process and allied industries.Read moreRead less
Nanostructured Silicon-Based Tandem Solar Cells. The expected outcome from the project is a new generation of low-cost silicon solar cell that will significantly reduce the costs of generating electricity from sunlight. Solar cells are presently the world's most rapidly growing energy source, with Australians and Australian companies already major players in the associated rapidly expanding industry. Solar cells represent the most benign technology yet suggested for supplying the world's future ....Nanostructured Silicon-Based Tandem Solar Cells. The expected outcome from the project is a new generation of low-cost silicon solar cell that will significantly reduce the costs of generating electricity from sunlight. Solar cells are presently the world's most rapidly growing energy source, with Australians and Australian companies already major players in the associated rapidly expanding industry. Solar cells represent the most benign technology yet suggested for supplying the world's future energy needs. A cleaner environment in the future than would otherwise be likely is another expected outcome as is the creation of major new opportunities for Australian industry.Read moreRead less