Preterm Birth And Exposure To Fine Particulate Matter
Funder
National Health and Medical Research Council
Funding Amount
$341,068.00
Summary
Preterm birth is the single most important cause of perinatal mortality and leading cause of subsequent morbidity in the western world. This project involves an investigation of the effects of fine airborne particulates and their chemical constituents on preterm birth among half a million pregnant women in Australia and the US. Levels of particulates will be rigorously assessed using traditional methods such as chemical analyses of field samples and novel methods such as processing satellite ima ....Preterm birth is the single most important cause of perinatal mortality and leading cause of subsequent morbidity in the western world. This project involves an investigation of the effects of fine airborne particulates and their chemical constituents on preterm birth among half a million pregnant women in Australia and the US. Levels of particulates will be rigorously assessed using traditional methods such as chemical analyses of field samples and novel methods such as processing satellite imagery.Read moreRead less
Assessing maternal exposure to persistent toxic substances and risk of adverse birth outcomes. There are numerous sources of persistent toxic substances (PTS) and due to their long half life in the environment they can increase in concentration over time, increasing the risks of human exposure. Australia is a signatory to the Stockholm Convention and this project both assists in the meeting Australia's obligations but also addresses the important subject of the relationship between environment, ....Assessing maternal exposure to persistent toxic substances and risk of adverse birth outcomes. There are numerous sources of persistent toxic substances (PTS) and due to their long half life in the environment they can increase in concentration over time, increasing the risks of human exposure. Australia is a signatory to the Stockholm Convention and this project both assists in the meeting Australia's obligations but also addresses the important subject of the relationship between environment, health and risk. The study will be the first of its type to systematically measure maternal exposure and link the risk of adverse birth outcomes. It will significantly improve our ability to assess the impact of chemicals on health. It will also provide benchmark information for a use in national standard setting and policy development. Read moreRead less
Occupational injury prevention in high temperature environments. This project aims to explore the contribution of heat as a risk factor in work-related illness and injury. Approximately 600 000 Australians experience a work-related illness or injury each year. Hot weather may directly or indirectly lead to accidents, but heat as a risk factor has not been systematically explored, and is particularly relevant in a warming climate. This project aims to improve safety and productivity in Australian ....Occupational injury prevention in high temperature environments. This project aims to explore the contribution of heat as a risk factor in work-related illness and injury. Approximately 600 000 Australians experience a work-related illness or injury each year. Hot weather may directly or indirectly lead to accidents, but heat as a risk factor has not been systematically explored, and is particularly relevant in a warming climate. This project aims to improve safety and productivity in Australian industry by generating new evidence and predictive models to inform injury prevention policy and guidance, and facilitating the development of practical, targeted resources. This project expects to add to the body of knowledge regarding workers’ health and safety and to be of benefit to industry and subpopulations at risk.Read moreRead less
Work-related fatal and non-fatal accidents and injuries and exposure to workplace hazards in migrant workers in Australia. Do migrants have worse workplace conditions and more work-related accidents and injuries than Australian-born workers? This project will analyse national deaths and hospital discharge data, and determine best practice methods to include migrant workers in a future cross-sectional study looking at occupational health and safety.
From science to policy: quantifying and managing the risk of mosquito borne disease in the context of climate change. It is important to assess and manage the health risks of climate change. This research will create fundamental knowledge and practical skills on the interdisciplinary assessment and management of health risks of climate change, and explore policy ramifications of research outcomes in this study.
Risks to human health and the ecosystem from feral pigs in Perth metropolitan water catchments. This project aims to investigate the potential risk feral pigs pose to public health through the dissemination of water borne pathogens within water catchment areas, and to investigate their role in the maintenance and spread of diseases of public and animal health concern in the south west of Western Australia. As well as providing a frontline approach to protecting our water supplies, this project ....Risks to human health and the ecosystem from feral pigs in Perth metropolitan water catchments. This project aims to investigate the potential risk feral pigs pose to public health through the dissemination of water borne pathogens within water catchment areas, and to investigate their role in the maintenance and spread of diseases of public and animal health concern in the south west of Western Australia. As well as providing a frontline approach to protecting our water supplies, this project will also provide valuable data on the nature and extent of the risk feral pigs pose to biodiversity conservation and the environment generally. The outcomes of this research will provide a scientific basis for the development of prioritised strategies for the control of feral pigs in Western Australia.Read moreRead less
Exposure To Diesel Exhaust And Lung Cancer Risk In Australia
Funder
National Health and Medical Research Council
Funding Amount
$581,519.00
Summary
Exposure to diesel exhaust increases the risk of lung cancer. One in five Australians is exposed to diesel exhaust in the workplace. This project will provide an exposure-response relation between diesel exhaust and lung cancer based on Australia-specific data. We will also estimate the number of lung cancer cases due to diesel exhaust exposure in Australia. We will do this by studying all miners in WA in the last 15 years, by linking several databases that are available in WA.
One of the current challenges in public health is to translate the progress from the Human Genome Project into reduced morbidity and mortality from disease. Once genetic defects are characterised, knowledge about the variability in severity of disease in mutation carriers, is important from a public health perspective. Hereditary Haemochromatosis (HH) is a common genetic disorder of iron overload that results in a wide spectrum of disease, varying from non-specific symptoms to severe damage to l ....One of the current challenges in public health is to translate the progress from the Human Genome Project into reduced morbidity and mortality from disease. Once genetic defects are characterised, knowledge about the variability in severity of disease in mutation carriers, is important from a public health perspective. Hereditary Haemochromatosis (HH) is a common genetic disorder of iron overload that results in a wide spectrum of disease, varying from non-specific symptoms to severe damage to liver, heart, pancreas and joints from iron deposition. It is easily treatable by regular blood donation, and population-based screening for HH has therefore been advocated. In this study we aim to address gaps in the existing data on HH regarding dietary and lifestyle factors that contribute to the variable clinical picture of HH. The study will be based on the Melbourne Collaborative Cohort Study, a cohort of 31,500 men and women who have been followed for approximately 10 years. Information on dietary and lifestyle factors was collected at initial enrollment, along with a blood specimen. We will test all non-Southern European participants (31,176) for the common HH mutations in the HFE gene and then select a subgroup of 1150 people, including all people with the main genetic defect as well as a comparison group, for further clinical followup. Participants will have genetic counselling and informed consent will be obtained. Participants will complete a short questionnaire and give a blood sample for measurement of iron overload, liver function, and other relevant blood tests, then undergo a brief clinical examination. Results of all tests will be given at a followup visit by genetic counsellor or physician. This study will provide important data on natural history of HH risk factors that influence variability in clinical presentation and the association of HFE mutations with chronic diseases and all cause mortality.Read moreRead less
Production, Fate and Transport of Cyanobacterial Toxins in Waterways. Australian waterways are under severe pressure from both large variation in precipitation patterns and various sources of contamination. In particular, the management of algal blooms costs Australians hundreds of millions of dollars a year. Through the use of a unique approach this project will provide the necessary information for a science based decision making strategies to eradicate, as much as possible, algal blooms and ....Production, Fate and Transport of Cyanobacterial Toxins in Waterways. Australian waterways are under severe pressure from both large variation in precipitation patterns and various sources of contamination. In particular, the management of algal blooms costs Australians hundreds of millions of dollars a year. Through the use of a unique approach this project will provide the necessary information for a science based decision making strategies to eradicate, as much as possible, algal blooms and to reduce the risk of severe injuries to the public, livestock and the environment, resulting from contamination waterways by algal toxins. Read moreRead less
Optimal management of corrosion and odour problems in sewer systems. Pollutants in wastewater undergo complex changes in sewers, leading to the production and release of odorous and corrosive compounds. Despite major efforts and expenditure by water utilities to mitigate these problems, odorous emissions from sewers are still commonly occurring in urban areas. Furthermore, the value of public assets is significantly diminished due to sewer corrosion, costing hundreds of millions of dollars a yea ....Optimal management of corrosion and odour problems in sewer systems. Pollutants in wastewater undergo complex changes in sewers, leading to the production and release of odorous and corrosive compounds. Despite major efforts and expenditure by water utilities to mitigate these problems, odorous emissions from sewers are still commonly occurring in urban areas. Furthermore, the value of public assets is significantly diminished due to sewer corrosion, costing hundreds of millions of dollars a year in Australia alone. This project is a major joint effort by the Australian water industry and world-leading scientists to generate advanced knowledge and develop effective technologies for optimal odour and corrosion management in sewers, delivering large social, environmental and economic benefits.Read moreRead less