Studies On The Expression Of Muscarinic Receptors: Implications For The Pathology Of Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$498,791.00
Summary
Schizophrenia is a severe psychiatric disorder that affects approximately 1% of the population. This project will help define changes in the molecules in the brain of subjects with schizophrenia which are likely to be involved in two symptoms of the disorder, the psychoses and cognitive deficits. Understanding the cause of the cognitive deficits of schizophrenia is a high priority because they are the most disabilitating symptom of the disorder and do not respond to current drug treatments.
Assessing Infrastructure And Contextual Factors In Relation To Cardiometabolic Outcomes In Remote Indigenous Communities: Evidence For Policy Change
Funder
National Health and Medical Research Council
Funding Amount
$1,113,005.00
Summary
Cardiometabolic diseases account for the major burden of morbidity and mortality for Indigenous populations. This study with 75 remote Indigenous communities will be the first to evaluate features of their social, built and physical environments in relation to cardiometabolic risks and diseases. Policy-relevant results will identify features of environments to be targeted to reduce chronic diseases for Indigenous peoples in remote communities.
Epigenetic Programming Of Immune Development In Utero: Role Of The Maternal Environment In The Allergy Epidemic
Funder
National Health and Medical Research Council
Funding Amount
$764,463.00
Summary
This study will provide new insights into the development of allergic disease. Specifically, we will explore the hypothesis that allergic disease and other disorders or immune dysregulation occur as a result of gene-environmental interactions in early life, and that these events begin in pregnancy when the developing fetus is still developing and most susceptible to these effects.
Health And Fertility Of Young Men Conceived Using Intra-cytoplasmic Sperm Injection
Funder
National Health and Medical Research Council
Funding Amount
$362,570.00
Summary
The injection of a single sperm into the egg (ICSI) has been the main IVF treatment for men with poor sperm quality since 1993 but is now often used for other types of infertility. Concern has been raised about the health of the children. We will approach >800 parents and their adult sons conceived using ICSI and will assess his general health and development, and fertility. This work will improve patient counselling and practice guidelines, and direct research into the safety of ICSI.
In-situ electrochemical generation of caustic and oxygen from sewage for emission control in sewers. This project aims to deliver an innovative technology that controls the emission of notorious compounds from sewer networks using chemicals directly produced from sewage, with electricity being the input. Compared to existing methods, this technology provides a much safer and more environmentally friendly solution, at less than 50 per cent of the cost.
Synthesis of Activated Carbon Supported Zero Valent Iron Nanoparticles and Application to Contaminant Degradation in Benthic Sediments. Sediment contamination is a major problem in harbours and estuaries around Australia. For example, in Sydney Harbour, a total fishing ban has been implemented as a result of excessive levels of dioxins and benzofurans in fish tissues. There is also concern at the possibility of large scale contamination of Botany Bay as a result of historic industrial activity a ....Synthesis of Activated Carbon Supported Zero Valent Iron Nanoparticles and Application to Contaminant Degradation in Benthic Sediments. Sediment contamination is a major problem in harbours and estuaries around Australia. For example, in Sydney Harbour, a total fishing ban has been implemented as a result of excessive levels of dioxins and benzofurans in fish tissues. There is also concern at the possibility of large scale contamination of Botany Bay as a result of historic industrial activity around the Bay. While dredging and on-land treatment of sediments is being adopted at the most severely contaminated sites, the cost of this approach is exorbitant. For sites where removal of contaminated sediments cannot be justified, the approach proposed in this study of a technology that entraps contaminants and enhances their in situ biodegradation is potentially a way forward.Read moreRead less
Cover crops that decrease phosphorus (P) transport from agricultural soils by increasing the efficiency of P fertiliser application. The aim of this project is to develop cover crop practices for the heavily fertilised potato cropping soils of the Robertson district that will minimise erosion and runoff of water potentially rich in phosphorus (P), thereby resulting in significant improvements in the environmental management of this sensitive catchment area. The cover crops will: (i) improve infi ....Cover crops that decrease phosphorus (P) transport from agricultural soils by increasing the efficiency of P fertiliser application. The aim of this project is to develop cover crop practices for the heavily fertilised potato cropping soils of the Robertson district that will minimise erosion and runoff of water potentially rich in phosphorus (P), thereby resulting in significant improvements in the environmental management of this sensitive catchment area. The cover crops will: (i) improve infiltration, decrease erosion, and off-site transport of P; (ii)increase access to accumulated soil P, making it available to a subsequent potato crop, thus decreasing the P loading of the soil; and (iii) have a biofumigation effect that will reduce the use of soil fumigants.
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Environmental Genomics: Mining, climate change, water, crime and health. The new Environmental Genomics approach will employ high-powered genome sequencing systems to perform some of the first detailed genetic studies of Australian environments. The resulting high-resolution data will comprise a genetic audit, providing essential information for the accurate measurement of climate and environmental change. This method will dramatically improve the speed, and power of environmental impact assessm ....Environmental Genomics: Mining, climate change, water, crime and health. The new Environmental Genomics approach will employ high-powered genome sequencing systems to perform some of the first detailed genetic studies of Australian environments. The resulting high-resolution data will comprise a genetic audit, providing essential information for the accurate measurement of climate and environmental change. This method will dramatically improve the speed, and power of environmental impact assessments, permitting responsible resource development with major benefits to industry and the economy. It will also create new tools to improve water management and quality, biosecurity, forensics/policing and human health, as reflected by the diverse range of industry partners supporting this project.Read moreRead less
A 60% efficient solar microconcentrator for electricity and hot water. The aim of this project is to develop a microconcentrator for deployment on house roofs that will produce both solar hot water and solar electricity with a combined efficiency above 60%. The system will have a low profile and will be nearly invisible from the street. The system will track the sun. Concentration will be accomplished by a mixture of refraction and reflection. About 20% of the sunlight will be converted to elect ....A 60% efficient solar microconcentrator for electricity and hot water. The aim of this project is to develop a microconcentrator for deployment on house roofs that will produce both solar hot water and solar electricity with a combined efficiency above 60%. The system will have a low profile and will be nearly invisible from the street. The system will track the sun. Concentration will be accomplished by a mixture of refraction and reflection. About 20% of the sunlight will be converted to electricity using lines of tiny solar cells, with the balance being converted to heat which is removed by cooling fluid and stored in hot water tanks.Read moreRead less
Seagrass tolerance of oil spills - scaling of pollution impacts. Seagrasses provide vital ecosystem services (such as sediment stabilisation and habitat provision) in Australian coastal waters. The contribution of pollutants to current seagrass decline is poorly understood. The Australian shipping industry is the 5th largest in the world but there is very little data on the impacts of petroleum hydrocarbons on intertidal seagrasses and hence no information for coastal resource managers to use in ....Seagrass tolerance of oil spills - scaling of pollution impacts. Seagrasses provide vital ecosystem services (such as sediment stabilisation and habitat provision) in Australian coastal waters. The contribution of pollutants to current seagrass decline is poorly understood. The Australian shipping industry is the 5th largest in the world but there is very little data on the impacts of petroleum hydrocarbons on intertidal seagrasses and hence no information for coastal resource managers to use in decision-making in the event of an oil spill. This project will assess the relative toxicities of a number of petroleum hydrocarbons on Australian seagrass species to provide necessary data for the development of effective management practice.Read moreRead less