New medicines are urgently needed for infectious diseases due to widespread resistance to many traditional antibiotics. This research will develop and apply state-of-the-art techniques to measure metabolism in parasites and bacteria, and reveal how drugs inhibit metabolic pathways in these microorganisms. This will provide important information about how current drugs work, and assist with the development of new medicines for infectious diseases.
The Role And Underlying Mechanisms Of Constitutional Epigenetic Silencing In Cancer Predisposition
Funder
National Health and Medical Research Council
Funding Amount
$218,617.00
Summary
Familial and young onset bowel and uterine cancer are usually caused by the inheritance of spelling mistakes in the genetic code within a set of cancer-protection genes. Recently, some patients were identified with their gene switched off by paralysing chemicals instead. This study aims to identify additional cancer cases with gene paralysis, determine if this arises in the presence or absence of a genetic change in front of the gene, and how gene paralysis is transmitted to the next generation.