Testing A Combination Of 2 Clinical Drugs, An IAP Inhibitor And P38 Inhibitor, To Treat AML
Funder
National Health and Medical Research Council
Funding Amount
$200,890.00
Summary
Current treatments only cure 50% of Acute Myeloid Leukaemia (AML) patients, and novel approaches to treatment are desperately needed to improve survival of patients with leukaemia. One new drug, Birinapant, is currently being tested in clinical trials to treat AML. I have found that some AMLs are resistant to Birinapant treatment but the addition of a second drug (called “p38 inhibitors”) can now overcome this resistance. I will test how effective combining these two drugs can be to treat AML.
A Randomised Controlled Trial Of Enhanced Parenting Capacity To Improve Developmental Outcomes In Preterm Infants
Funder
National Health and Medical Research Council
Funding Amount
$1,045,141.00
Summary
In Australia there are 2, 600 very preterm survivors each year. 50% will have education/behavioural difficulties and 10% major disability. We aim to optimise the development of infants born very preterm through a tailored Positive Parenting Program. We predict reductions in child behavioural and emotional problems at 2 years corrected age.
Investigating Causes Of Stillbirths: A Prospective Cohort Study Examining Use And Effectiveness Of A Comprehensive Investigation Protocol
Funder
National Health and Medical Research Council
Funding Amount
$567,508.00
Summary
The effects of stillbirth on women and their families are often devastating and long term. Many stillbirths are not appropriately investigated, resulting in lack of accurate data on causes with one-third classified as unexplained. A major driver for suboptimal investigation is the lack of research to guide which tests should be done. This study aims to accurately identify causes of death in 984 comprehensively investigated stillbirths and determine which tests are needed, with consideration of c ....The effects of stillbirth on women and their families are often devastating and long term. Many stillbirths are not appropriately investigated, resulting in lack of accurate data on causes with one-third classified as unexplained. A major driver for suboptimal investigation is the lack of research to guide which tests should be done. This study aims to accurately identify causes of death in 984 comprehensively investigated stillbirths and determine which tests are needed, with consideration of costs and value.Read moreRead less
The Validity Of ‘8 Instruments’ Used To Include Quality Of Life In Economic Evaluation In 8 Disease Areas And 6 Countries
Funder
National Health and Medical Research Council
Funding Amount
$856,212.00
Summary
The Quality of Life is incorporated in the economic evaluation of health services using different ‘utility instruments’. Small scale comparative studies reveal large discrepancies between measurements. Very few studies combine multiple utility and disease specific instruments and to date no studies have compared utility instruments with scales measuring subjective wellbeing (happiness) or human capabilities. This project will mount the largest cross national survey to date of these questions.
Developing An Australian Valuation For The EQ-5D-5L Quality Of Life Instrument
Funder
National Health and Medical Research Council
Funding Amount
$348,357.00
Summary
In the assessment of gains resulting from a health technology, it is standard to consider both mortality and quality of life effects. This project explores how Australians value different components of quality of life. To do this, we are running an online survey called a discrete choice experiment, and analysing the data using a range of cutting-edge econometric techniques. This will allow policy-makers to better reflect people's preferences when making decisions about new technologies.
Measuring Health Related Social Preferences And Their Inclusion In An Alternative Method For Prioritising Health Services
Funder
National Health and Medical Research Council
Funding Amount
$430,143.00
Summary
The project measures the public preference for sharing the health budget rather than maximising average health. It quantifies the importance of severity, patient age and health potential and illustrates an alternative criterion to the maximisation of cost effectiveness for the allocation of the health budget.
The Arthroplasty And Bariatric Surgery (ABS) Study: A Randomised Controlled Trial Of Laparoscopic Adjustable Gastric Banding Prior To Total Knee Arthroplasty
Funder
National Health and Medical Research Council
Funding Amount
$664,149.00
Summary
Knee replacement is a common surgical procedure in Australia (40,000 per year). More than 60% of this group are obese and this is associated with higher early (clinical) and long term (implant) survival complications. Laparoscopic adjustable gastric banding (LAGB) is an effective and safe means of achieving sustained weight loss. This study compares the outcomes of total knee replacement in groups of obese patients who have and have not undergone pre-knee replacement LAGB.
Waxing And Waning Of Asthma During Transition From The Teens To Adulthood: Identification Of Immunophenotypic Markers To Predict Disease Trajectory And Guide Development Of Treatment Strategies To Prevent Progression To Chronicity
Funder
National Health and Medical Research Council
Funding Amount
$736,166.00
Summary
The project will seek to identify biomarkers in teenage/young adult asthmatics that can distinguish between those who are "growing out" of the disease, versus those who are progressing towards chronic severe asthma. This knowledge will inform the development of more effective treatment programs for this age group.
Development And Valuation Of Cancer-specific Multi-attribute Health States For Use In Economic Evaluation
Funder
National Health and Medical Research Council
Funding Amount
$707,671.00
Summary
Economic evaluation is used by the Australian government in deciding which medical services and pharmaceuticals should be funded. This study will develop quality of life utility measures for use in economic evaluation of cancer interventions in Australia and internationally. This represents a significant methodological contribution to the assessment of quality of life, effectiveness and efficiency in cancer, in one of Australia's national health priority areas.
Improving Alcohol Treatment Outcomes: The Impact Of Client, Intervention And System Variables On Treatment Outcomes.
Funder
National Health and Medical Research Council
Funding Amount
$1,525,879.00
Summary
Patient outcomes are significantly influenced by a number of factors including the characteristics of the patient, the type of treatment provided, and the characteristics of the system in which care is delivered. This study aims to determine how these factors influence outcomes for people seeking treatment for alcohol dependence. It will provide critical information for policy makers on which to base minimum service standards.