Pathophysiology And Alternative Preventative Strategy For Breast Cancer Chemotherapy-induced Bone Loss
Funder
National Health and Medical Research Council
Funding Amount
$540,356.00
Summary
Combination cytotoxic chemotherapy is the current optimal approach for treating breast cancer in premenopausal women. However, long-term skeletal defects (osteoporosis and fractures) caused by the chemotherapy have become an increasingly serious problem due to its intensified use and improved patient survival rate. This project seeks to elucidate the mechanisms for chemotherapy-induced bone defects and to initiate development of a preventative treatment using natural bioactive micronutrients.
Coverage with Evidence Development: Application to pharmaceutical reimbursement decisions. Some new medicines produce only a small improvement in health but have considerable costs. When these medicines are trialled on only small numbers of people, uncertainty results about the value of the medicine, which can create problems for decision makers. Funding medicines where there is uncertainty may lead to harm when medicines are later found to be unsafe, or waste millions of dollars when they are ....Coverage with Evidence Development: Application to pharmaceutical reimbursement decisions. Some new medicines produce only a small improvement in health but have considerable costs. When these medicines are trialled on only small numbers of people, uncertainty results about the value of the medicine, which can create problems for decision makers. Funding medicines where there is uncertainty may lead to harm when medicines are later found to be unsafe, or waste millions of dollars when they are overpriced relative to effectiveness. Not funding medicines may disadvantage patients in whom the medicines are effective. Methods to enable access to medicines while reducing uncertainty will offer significant benefit to patients, clinicians and taxpayers. Read moreRead less
To what extent does Australian food policy consider its health impact. This research will examine how public policies relating to food can be made healthier. The diet of Australians currently contributes to high rates of disease including diabetes, heart disease and the underlying issue of obesity. It will examine Australian agriculture and food processing, manufacturing and marketing and the environmental impacts of these sectors. The research will analyse policy documents and interview key peo ....To what extent does Australian food policy consider its health impact. This research will examine how public policies relating to food can be made healthier. The diet of Australians currently contributes to high rates of disease including diabetes, heart disease and the underlying issue of obesity. It will examine Australian agriculture and food processing, manufacturing and marketing and the environmental impacts of these sectors. The research will analyse policy documents and interview key people involved in each sector to determine their views on the ways in which our food supply affects our health. It will result in policy recommendations advising how the Australian food sector can be made more supportive of health and equity. Policy makers will be engaged with our findings through a Food Policy Summit. Read moreRead less
Native fish stocking of rivers: discriminating between hatchery-reared and wild fish. Stocking of fish is widely used in attempts to restore native fish populations. Little is known of the fate of stocked fish or the effects of stocking on resident populations. We will develop and evaluate protocols for chemical marking of otoliths of hatchery-reared fish so that their source can be determined. Experimental stocking of hatchery-reared fish will be undertaken and population structure and sourc ....Native fish stocking of rivers: discriminating between hatchery-reared and wild fish. Stocking of fish is widely used in attempts to restore native fish populations. Little is known of the fate of stocked fish or the effects of stocking on resident populations. We will develop and evaluate protocols for chemical marking of otoliths of hatchery-reared fish so that their source can be determined. Experimental stocking of hatchery-reared fish will be undertaken and population structure and source of stocked versus wild fish determined in stocked and unstocked rivers. Natural chemical signatures will also help determine important recruitment areas. The outcomes will allow fisheries managers to make informed decisions regarding stocking strategies.Read moreRead less
Putting death in its place. The project aims to link 890,000 population records to place of residence from 1838 to 1930, to examine the relationships between where people live, mortality, life expectancy and health. Where people live impacts their life-course outcomes. Using novel matching techniques, the project expects to identify intergenerational changes and the spatial dynamics of inequality and social mobility. Expected outcomes include the creation of a public resource of linked data and ....Putting death in its place. The project aims to link 890,000 population records to place of residence from 1838 to 1930, to examine the relationships between where people live, mortality, life expectancy and health. Where people live impacts their life-course outcomes. Using novel matching techniques, the project expects to identify intergenerational changes and the spatial dynamics of inequality and social mobility. Expected outcomes include the creation of a public resource of linked data and a better understanding of long-run health and inequality. These should provide economic and social benefits by informing policy aimed at contemporary social and health challenges, enhancing our understanding of Australian history, and developing public resources.Read moreRead less
Bad tastes, odours and toxins in our drinking water reservoirs: are benthic cyanobacteria the culprits? Cyanobacteria (blue-green algae) produce toxins and bad tastes that contaminate drinking water sources, cause public concern about water quality. This project will address a critical knowledge gap by investigating species that grow on the sediments of reservoirs, thus providing more comprehensive management solutions to the water industry.
The Macroderma initiative: conserving ghost bats and informing development. This project aims to improve methods for capturing biological information required for environmental assessments of highly mobile species and enable strategic environmental planning in Northern Australia. Using Australia’s iconic ghost bat as a focus, the project will test and apply emerging technologies to obtain key information on a species’ population status and its critical resources to inform assessments of ecologic ....The Macroderma initiative: conserving ghost bats and informing development. This project aims to improve methods for capturing biological information required for environmental assessments of highly mobile species and enable strategic environmental planning in Northern Australia. Using Australia’s iconic ghost bat as a focus, the project will test and apply emerging technologies to obtain key information on a species’ population status and its critical resources to inform assessments of ecological impacts of industry development. Important benefits of the project include information and tools for streamlining development approvals and accurately assessing risks to threatened species to improve outcomes for both our economy and our natural environment.Read moreRead less
Socio-cultural Factors and the Use of Therapeutic Opioids in Indonesia. This project aims to determine how legal, policy and socio-cultural factors influence the use of therapeutic opioids in Indonesia. The project expects to generate a nuanced understanding of the impact of non-medical considerations in contested areas of health policy through its multidisciplinary and multi-scalar approach. We expect outcomes to include a robust model of influences on decision-making that can be applied in Ind ....Socio-cultural Factors and the Use of Therapeutic Opioids in Indonesia. This project aims to determine how legal, policy and socio-cultural factors influence the use of therapeutic opioids in Indonesia. The project expects to generate a nuanced understanding of the impact of non-medical considerations in contested areas of health policy through its multidisciplinary and multi-scalar approach. We expect outcomes to include a robust model of influences on decision-making that can be applied in Indonesia and adapted for use in other national contexts. This should provide significant benefits, including an innovative training program to empower doctors and pharmacists to make evidence-based decisions about the potential risks and benefits, both medical and social, of opioid-based treatment options.Read moreRead less
Improving Nutrition And Health Outcomes For Women And Babies In The Aboriginal Family Birthing Program
Funder
National Health and Medical Research Council
Funding Amount
$975,882.00
Summary
Young Aboriginal women are more likely to have children when they are under 25 than other women in SA. They are also much more likely to be overweight or obese. Together these two characteristics have profound consequences for a woman's health and increased risks for poor birth outcomes. A novel package of culturally appropriate and intensive nutrition strategies, embedded in the SA Aboriginal Family Birthing Program will be developed and assessed to see its impact on women's and child health.
Effectiveness of Intervention Strategies to Promote Physical Activity Among Insufficiently Active Adults. This project will determine the cost-effectiveness of 2 types of physical activity (PA) interventions based around the workplace. 480 participants will be randomly assigned to PA intervention groups or controls. Interventions are either a (1) self-regulated, pedometer-based program or a (2) semi-structured, 40-day initiation to more moderately-vigorous PA. Both are designed to increase self- ....Effectiveness of Intervention Strategies to Promote Physical Activity Among Insufficiently Active Adults. This project will determine the cost-effectiveness of 2 types of physical activity (PA) interventions based around the workplace. 480 participants will be randomly assigned to PA intervention groups or controls. Interventions are either a (1) self-regulated, pedometer-based program or a (2) semi-structured, 40-day initiation to more moderately-vigorous PA. Both are designed to increase self-efficacy and impact on positive PA behaviours. Long-term, behavioural change and job-related outcomes will be evaluated by following participants for 12 months after the interventions.Read moreRead less