Improving neuronal cell function with cell permeable copper complexes. Metal-based drugs offer an exciting new approach to treatment of neurodegeneration. However, little is known about how cells metabolise these drugs and this information is critical for further drug development. This project will determine how metal-based drugs are metabolised by neuronal cells and how this may result in therapeutic benefit.
Understanding old age in Australian history as a foundation for improved social and economic policy. My history of old age in Australia since 1860 will provide the first book which maps our experiences of growing old in the past, as a foundation for improved social and economic policy. The national government's 'Inter-generational report' has started a process of review and planning at a time of dramatic demographic change. However, developing strategies for 'ageing well, ageing productively' d ....Understanding old age in Australian history as a foundation for improved social and economic policy. My history of old age in Australia since 1860 will provide the first book which maps our experiences of growing old in the past, as a foundation for improved social and economic policy. The national government's 'Inter-generational report' has started a process of review and planning at a time of dramatic demographic change. However, developing strategies for 'ageing well, ageing productively' depends on an informed understanding of previous and current expectations about and attitudes to ageing in Australia. The history of old age is a complex rather than simple story, and successful policy development will require a solid historical foundation.Read moreRead less
Chromatin structure and pervasive transcription. This project aims to understand mechanisms that repress pervasive transcription and to identify chromatin characteristics that repress transcription initiation outside the promoter regions. Chromatin characteristics, such as position, occupancy and turnover-rate of nucleosomes, establish an elaborate genomic indexing mechanism, which defines functional units in the genome. Defects in this process increase pervasive transcription, toxic accumulatio ....Chromatin structure and pervasive transcription. This project aims to understand mechanisms that repress pervasive transcription and to identify chromatin characteristics that repress transcription initiation outside the promoter regions. Chromatin characteristics, such as position, occupancy and turnover-rate of nucleosomes, establish an elaborate genomic indexing mechanism, which defines functional units in the genome. Defects in this process increase pervasive transcription, toxic accumulation of non-coding transcripts and genomic instability. This work aims to understand eukaryotic genome organisation and may have long-term therapeutic implications for cancer and ageing-related diseases.Read moreRead less
Observations of remarkable eastward flows in the South Indian Ocean. The Indian Ocean drives much of the variability of Australian weather and rainfall and is rapidly evolving. Innovative new observations of remarkable eastward flows in the South Indian Ocean will be combined with models to understand these circulations in a region that has significant economic value for Australia.
Advancing dynamical understanding in the East Australian Current: Optimising the ocean observation and prediction effort. The East Australian Current is a highly dynamic system, thus is very difficult to observe, measure and predict. Our aim is to advance the dynamical understanding of this complex system and to quantify the value of specific observations in improving ocean state-estimates. State-estimates are critical for robust ocean predictions in a region that is warming faster than anywhere ....Advancing dynamical understanding in the East Australian Current: Optimising the ocean observation and prediction effort. The East Australian Current is a highly dynamic system, thus is very difficult to observe, measure and predict. Our aim is to advance the dynamical understanding of this complex system and to quantify the value of specific observations in improving ocean state-estimates. State-estimates are critical for robust ocean predictions in a region that is warming faster than anywhere else on the planet. This project will integrate innovative numerical modeling techniques with a state-of-the-art ocean observing system. The expected outcomes will guide future ocean observing efforts; maximising impact while reducing cost. The results will be readily applicable to analogous systems around the world and our team is well placed to implement them internationally.Read moreRead less
New methods for structure analysis of proteins and protein interactions. This project will advance nuclear magnetic resonance (NMR) technologies pioneered at the Australian National University which employ site-specific attachment of paramagnetic metal tags to proteins. A new and diverse set of strategies will dramatically extend the range of applications to targets of interest in the fight against cancer and bacterial infections.
A Laboratory Study of Ocean-Atmosphere Coupling in the Antarctic Circumpolar Wave. A laboratory model of the southern hemisphere mid-latitude ocean-atmosphere system will be used to investigate the dynamics of ocean-atmosphere coupling contributing to the Antarctic Circumpolar Wave (ACW). The ACW is a recently discovered multi-year climate oscillation which has considerable effect on Australian and New Zealand precipitation. This will be the first laboratory model to include global scale ocean-a ....A Laboratory Study of Ocean-Atmosphere Coupling in the Antarctic Circumpolar Wave. A laboratory model of the southern hemisphere mid-latitude ocean-atmosphere system will be used to investigate the dynamics of ocean-atmosphere coupling contributing to the Antarctic Circumpolar Wave (ACW). The ACW is a recently discovered multi-year climate oscillation which has considerable effect on Australian and New Zealand precipitation. This will be the first laboratory model to include global scale ocean-atmosphere processes, and will be used to test proposed mechanisms for the driving of the climate oscillation that is attributed to the ACW. The project will provide knowledge required for improved computational modelling and climate predictions.
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Involvement of cell coupling in vascular function: Development of a computational model. Gap junctions are intercellular channels which enable the production of coordinated responses in multicellular tissues and organs. Blood vessels are comprised of endothelial cells surrounded by smooth muscle cells and gap junctions exist within and between these layers. The present proposal will determine the fundamental role of gap junctions in regulating blood flow and blood pressure. Our data will enable ....Involvement of cell coupling in vascular function: Development of a computational model. Gap junctions are intercellular channels which enable the production of coordinated responses in multicellular tissues and organs. Blood vessels are comprised of endothelial cells surrounded by smooth muscle cells and gap junctions exist within and between these layers. The present proposal will determine the fundamental role of gap junctions in regulating blood flow and blood pressure. Our data will enable us to develop a computational model of the vascular wall and so predict how changes in electrical properties, as occur during pressure changes, can influence blood flow. Since ageing is accompanied by an increase in blood pressure, our results will contribute to a better understanding of blood flow regulation in our ageing population.Read moreRead less
Causes of Enhanced Warming of the Southern Ocean. The Southern Ocean is critical to the global climate system in general, and Australian climate in particular. However, the Southern Ocean is poorly understood, poorly observed and poorly modelled by global climate models. The response of the Southern Ocean to increases in wind forcing (due to the ozone hole and global warming) will be examined. Climate impacts such as Australian rainfall trends, potential instability of the West Antarctic Ice She ....Causes of Enhanced Warming of the Southern Ocean. The Southern Ocean is critical to the global climate system in general, and Australian climate in particular. However, the Southern Ocean is poorly understood, poorly observed and poorly modelled by global climate models. The response of the Southern Ocean to increases in wind forcing (due to the ozone hole and global warming) will be examined. Climate impacts such as Australian rainfall trends, potential instability of the West Antarctic Ice Sheet and changes to the global overturning circulation will be quantified. Understanding these impacts will help to manage Australia's water resources and to predict the future Southern Ocean circulation.Read moreRead less
Australia's ocean microbiome: how the diversity and functionality of microbes influence key oceanographic provinces. Every millilitre of seawater contains millions of microbes that maintain the health of our planet, but their identity and function in Australian waters is undefined. This project will identify the microbes inhabiting Australian marine systems, elucidate the services they provide, and predict how they will be affected by future environmental changes