Interactions of Insulin-like Growth Factors and their Binding Proteins with Vitronectin: a structural basis for antagonist design and development. Tissue Therapies Ltd has shown that a patented combination of three biosynthetic molecules, VitroGroR, can promote tissue repair effectively. This project will use biophysical and biochemical techniques to investigate precisely how these molecules interact, and hence provide a rational basis for future developments and improvements of this exciting n ....Interactions of Insulin-like Growth Factors and their Binding Proteins with Vitronectin: a structural basis for antagonist design and development. Tissue Therapies Ltd has shown that a patented combination of three biosynthetic molecules, VitroGroR, can promote tissue repair effectively. This project will use biophysical and biochemical techniques to investigate precisely how these molecules interact, and hence provide a rational basis for future developments and improvements of this exciting new therapeutic strategy.
Conversely, this information would also facilitate the development of antagonists to VitroGroR complexes would provide novel opportunities to treat diseases such as cancer and atherosclerosis that involve excessive production of its component molecules.Read moreRead less
DNA methylation-based diagnosis of cancer and identification of novel therapeutic targets. In our aging society, cancer represents a severe economic and quality-of-life threat. DNA methylation switches genes off, and recently, it was shown that defects in DNA methylation contribute to human diseases including cancer. This project will identify defects in DNA methylation associated with cancer. Identifying these defects will enable us to design non-invasive, early diagnostic tests for cancer on b ....DNA methylation-based diagnosis of cancer and identification of novel therapeutic targets. In our aging society, cancer represents a severe economic and quality-of-life threat. DNA methylation switches genes off, and recently, it was shown that defects in DNA methylation contribute to human diseases including cancer. This project will identify defects in DNA methylation associated with cancer. Identifying these defects will enable us to design non-invasive, early diagnostic tests for cancer on blood or bodily excretions, and to pursue novel therapeutic approaches for treating cancer. The expected outcomes would generate exports to markets in the USA and Europe and replace imports of drugs and technology to treat cancer.Read moreRead less
Sino-Australian neurogenetics initiative. This project will undertake large population studies to identify genes that are associated with motor neuron disease, schizophrenia and intracranial haemorrhage. The project will determine genetic markers, aid development of diagnostic tools and identify new therapeutic targets for these common heritable neurological diseases.
Architecture and healthy ageing: an investigation into the relationship between aged care facility design, management and the well being of residents. Residential care for the future will need to meet expanding demands for aged care in a manner which responds to more discerning older people including those from non-English speaking backgrounds and Aboriginal and Torres Strait Islanders with expected increases in the number of services required. To do so design processes must incorporate the need ....Architecture and healthy ageing: an investigation into the relationship between aged care facility design, management and the well being of residents. Residential care for the future will need to meet expanding demands for aged care in a manner which responds to more discerning older people including those from non-English speaking backgrounds and Aboriginal and Torres Strait Islanders with expected increases in the number of services required. To do so design processes must incorporate the needs of those involved in residential care yet meet the requirements of statutory authorities standards for health care provision. This research will provide a comprehensive picture of the issues that impact on the design process and the effect on residential care facilities ability to provide residents and workers with the highest possible quality of life. It will inform accreditation and certification standards.Read moreRead less
Brides and Grandmothers: Challenges for Older Filipinos in Australia. This project investigates the settlement, acculturation experiences, and psychological wellbeing of older Filipino women who arrived in Australia under different circumstances. Some have migrated to Australia as young brides to marry Australian citizens and some as grandmothers to be reunited with family members. Five hundred older Filipino women, and a group of 100 men living in rural and urban areas, will participate in the ....Brides and Grandmothers: Challenges for Older Filipinos in Australia. This project investigates the settlement, acculturation experiences, and psychological wellbeing of older Filipino women who arrived in Australia under different circumstances. Some have migrated to Australia as young brides to marry Australian citizens and some as grandmothers to be reunited with family members. Five hundred older Filipino women, and a group of 100 men living in rural and urban areas, will participate in the project. The findings will enhance the understanding of the social and psychological needs of this special group of migrants and will assist in the planning of immigration policies and culturally appropriate health services for older migrants.Read moreRead less
Australian art exhibitions 1968-2009: a generation of cultural transformation. The years 1968 to 2009 witnessed a transformation in the way Australians saw the art of their country. This project investigates the impact of increased funding (government and private) and new scholarship on the curating of art exhibitions, and traces the reconfiguration of Australia’s art history that took place in exhibitions during this period.
Investigation of the biology of insulin-like growth factor 1 and its derivatives for the development of new therapeutics. This project will investigate the biology of insulin-like growth factor 1, a key molecule in growth, development and, in particular, the wound healing process. Its success will lead to improved treatments for non-healing (chronic) wounds and, potentially, new anti-cancer treatments.
Responding to the rural skills crisis: Modelling volunteer motivations and incentives to attract retired/semi-retired professionals to volunteer in rural areas. This project contributes directly to Promoting and Maintaining Good Health: Ageing well, ageing productively by placing a high value on the skills of older Australians and encouraging them to remain productive into retirement by sharing these skills. This project will also strengthen the social and economic fabric of rural communities by ....Responding to the rural skills crisis: Modelling volunteer motivations and incentives to attract retired/semi-retired professionals to volunteer in rural areas. This project contributes directly to Promoting and Maintaining Good Health: Ageing well, ageing productively by placing a high value on the skills of older Australians and encouraging them to remain productive into retirement by sharing these skills. This project will also strengthen the social and economic fabric of rural communities by addressing the identified national priority area of skills shortages in rural areas by providing rural councils with a means to access skilled professionals to assist them in enhancing their economic and social sustainability. Further, use of sound, well-tested psychological theories of individual decision making will enhance the validity and applicability of the model.Read moreRead less
A national framework for managing malignant plastics in museum collections. A national framework for managing malignant plastics in museum collections. This collaborative project between three universities, four museums and an art gallery aims to discover how to predict and increase the lifespan of malignant plastics or polymers by studying their identification, deterioration and conservation. 5 to 80% of museum collections, composed of growing numbers of plastic or polymer-based materials, need ....A national framework for managing malignant plastics in museum collections. A national framework for managing malignant plastics in museum collections. This collaborative project between three universities, four museums and an art gallery aims to discover how to predict and increase the lifespan of malignant plastics or polymers by studying their identification, deterioration and conservation. 5 to 80% of museum collections, composed of growing numbers of plastic or polymer-based materials, need better preservation. Conservators do not have much expertise in preserving plastics, which are contemporary and have a relatively short life expectancy. This project intends to provide museums with a model for prioritising and effectively allocating resources to preserve a vulnerable group of collections for future generations.Read moreRead less
ISim - a realistic intubation simulator using Virtual Reality technology. Simulation training has been adopted widely in aerospace, nuclear power and the military, but simulation in medicine has a relatively short history. This research will drive Australia to the forefront of the medical simulation industry. Effective management and treatment of patients is a priority in health care. Medical resources are required to ensure that staff are trained efficiently and effectively on critical medical ....ISim - a realistic intubation simulator using Virtual Reality technology. Simulation training has been adopted widely in aerospace, nuclear power and the military, but simulation in medicine has a relatively short history. This research will drive Australia to the forefront of the medical simulation industry. Effective management and treatment of patients is a priority in health care. Medical resources are required to ensure that staff are trained efficiently and effectively on critical medical procedures. The high growth of claims for medical accidents and the accompanying rise in medical insurance adds to the impetus for major hospitals to demonstrate they are using advanced methods for training. The community will benefit from better-trained medical staff, and a better standard of healthcare. Read moreRead less