Multivariate Methods for the Analysis of Microarray Gene-Expression Data with Applications to Cancer Diagnostics. The project will benefit the Australian Society as a whole by developing statistical methodology for the analysis of high-throughput data. In particular, it will develop a novel and easily implemented model for the analysis of correlated and structured data that may be of high dimension. It thus has wide applicability to improving the quality and validity of applied research in most ....Multivariate Methods for the Analysis of Microarray Gene-Expression Data with Applications to Cancer Diagnostics. The project will benefit the Australian Society as a whole by developing statistical methodology for the analysis of high-throughput data. In particular, it will develop a novel and easily implemented model for the analysis of correlated and structured data that may be of high dimension. It thus has wide applicability to improving the quality and validity of applied research in most industries in Australia. More specifically, it is to be applied here to the diagnosis and prognosis of ovarian cancer. This cross-disciplinary project will strengthen Australian researchers' capacity and capability of participating in cutting-edge DNA microarray research.
Read moreRead less
QUA:Queensland digital Ultra-Atlas. This project aims to design and develop a digital ultra-atlas of Queensland which integrates the capabilities of GIS(geographical information system) with interactive 4D graphical modelling,knowledge extraction and context-based query and retrieval. This ultra-atlas would allow users to discover knowledge on natural resources,cultural characteristics and historical changes,as well as simulating different effects by providing advanced search capabilities and en ....QUA:Queensland digital Ultra-Atlas. This project aims to design and develop a digital ultra-atlas of Queensland which integrates the capabilities of GIS(geographical information system) with interactive 4D graphical modelling,knowledge extraction and context-based query and retrieval. This ultra-atlas would allow users to discover knowledge on natural resources,cultural characteristics and historical changes,as well as simulating different effects by providing advanced search capabilities and engaging display of spatial and thematically-linked data. Such an ultra-atlas would have enormous impact on facilitating strategic planning and performance in many applications(e.g fire control,environment and urban planning).Read moreRead less
Efficient Similarity Query Processing in High Dimensional Databases. This project studies a fundamental problem common to a wide range of applications. It contributes to smart use of information, which is vital to the modern knowledge-based economy, by providing an enabling technology to capitalise Australia's huge investment in data collection. Our research is right in the forefront of ICT research, leading the international effort of extending database technologies to support data management a ....Efficient Similarity Query Processing in High Dimensional Databases. This project studies a fundamental problem common to a wide range of applications. It contributes to smart use of information, which is vital to the modern knowledge-based economy, by providing an enabling technology to capitalise Australia's huge investment in data collection. Our research is right in the forefront of ICT research, leading the international effort of extending database technologies to support data management and query processing for very large and highly complex data.Read moreRead less
Context Exploration: An Effective Way to Enhance Duplication Detection. As a vital data quality problem, effective duplication detection has practical significance in data management, in particular in large scale information systems such as in business, health and national security. This project aims to be a unique value to virtually every information systems by providing a general, domain-independent framework which is comprehensive to significantly improve the duplication detection. The develo ....Context Exploration: An Effective Way to Enhance Duplication Detection. As a vital data quality problem, effective duplication detection has practical significance in data management, in particular in large scale information systems such as in business, health and national security. This project aims to be a unique value to virtually every information systems by providing a general, domain-independent framework which is comprehensive to significantly improve the duplication detection. The developed cutting-edge technologies are potential to be a new direction of data duplication detection study. This project will allow us to avail an opportunity to promote Australia's capability in developing sophisticated technologies and are potential to add to Australia's profile in this area. Read moreRead less
Spatio-temporal modelling of Ras dependent MAP kinase activation. This project is at the heart of the national research priority 'Frontier Technologies for Building and Transforming Australian Industries'. Using cutting edge methods and techniques of systems biology, coupled with innovative experimental molecular cell biology we will construct and simulate mathematical models of the EGF-regulated MAP kinase pathway. The project will yield new insights into the fundamental mechanisms of cell sign ....Spatio-temporal modelling of Ras dependent MAP kinase activation. This project is at the heart of the national research priority 'Frontier Technologies for Building and Transforming Australian Industries'. Using cutting edge methods and techniques of systems biology, coupled with innovative experimental molecular cell biology we will construct and simulate mathematical models of the EGF-regulated MAP kinase pathway. The project will yield new insights into the fundamental mechanisms of cell signal transduction that drive cell division, differentiation and transformation and may enable the design of new anticancer therapies. Importantly, the modelling and simulation methods developed in the project will have a general applicability to other complex systems such as sustainable ecological systems.Read moreRead less
Stochastic Modelling of Genetic Regulatory Networks: Subtitle - Genetic Regulation is a Noisy Business. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in ....Stochastic Modelling of Genetic Regulatory Networks: Subtitle - Genetic Regulation is a Noisy Business. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in cellular processes. This project will explore these roles and will develop an integrated complex systems modelling, simulation and visualisation framework. This will be used on an exemplar application for lineage commitment in haematopoiesis and for exploring and validating genetic regulatory models in general.Read moreRead less
Multiscale stochastic modelling of genetic regulatory mechanisms. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in cellular processes. This project will ex ....Multiscale stochastic modelling of genetic regulatory mechanisms. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in cellular processes. This project will explore these roles and will develop an integrated complex systems modelling, simulation and visualisation framework for exploring and validating genetic regulatory models in general. This will be used on an exemplar application for understanding the induction process in lambda phage.Read moreRead less