Cellular mechanisms that protect against copper-bound beta-amyloid. This project will investigate some of the brain’s own mechanisms for protecting itself against Alzheimer’s disease. Understanding these mechanisms will be important for developing future therapeutic strategies for treating Alzheimer’s disease.
The Tasmanian Healthy Brain Project: A Longitudinal Intervention Study To Reduce The Risk Of Ageing-related Cognitive Decline And Dementia
Funder
National Health and Medical Research Council
Funding Amount
$878,792.00
Summary
It has been proposed that engagement in purposeful complex mental stimulation provides protection against dementia. The Tasmanian Healthy Brain Project (THBP) is a unique, large-scale prospective trial that examines whether university-level study in older adult population reduces ageing-related cognitive decline and risk of dementia. This project will also examine how an individual’s genetic profile may influence the potential benefits of complex mental stimulation as well as risk of dementia.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100006
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
An adaptable and dedicated linear accelerator for medical radiation research. Leading radiation scientists developing innovative methods and devices for treating cancer patients will collaborate in future research using this highly adaptable linear accelerator for medical radiation research. Innovations in tumour targeting, better patient safety, new medical devices and improved cancer outcomes are expected.
The Southern Ocean Meridional Overturning Circulation: New observations of vertical mixing. The Southern Ocean and Antarctic Circumpolar Current (ACC) play profound roles in Australian and global climate. However, we know little about how they will be affected by global warming. New velocity observations will tell us how the vertical mixing that contributes to the meridional overturning circulation, and ACC strength, change with the seasons and from year to year. The observations will also gi ....The Southern Ocean Meridional Overturning Circulation: New observations of vertical mixing. The Southern Ocean and Antarctic Circumpolar Current (ACC) play profound roles in Australian and global climate. However, we know little about how they will be affected by global warming. New velocity observations will tell us how the vertical mixing that contributes to the meridional overturning circulation, and ACC strength, change with the seasons and from year to year. The observations will also give us a better understanding of the oceanic and atmospheric processes that drive these changes. This new information will allow climate models to be better constrained so they can more accurately predict changes to Australian and global climate.Read moreRead less
The Healthy Brain Project: A Prospective Cohort Study To Examine How Later-life University Education May Affect The Trajectory Of Ageing-related Cognitive Decline
Funder
National Health and Medical Research Council
Funding Amount
$1,085,742.00
Summary
Previous research has indicated that higher levels of education in early adulthood are associated with lower risk for dementia in older adults. This world-first project will examine if older adults who undertake university education have reduced rates of age-related cognitive decline than older adults who do not undertake further education. This would support the notion that boosting cognitive reserve in later life is protective against age- and disease-related neurodegenerative change.
Observations of remarkable eastward flows in the South Indian Ocean. The Indian Ocean drives much of the variability of Australian weather and rainfall and is rapidly evolving. Innovative new observations of remarkable eastward flows in the South Indian Ocean will be combined with models to understand these circulations in a region that has significant economic value for Australia.
Discovery Early Career Researcher Award - Grant ID: DE170101514
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
The control of neuroplasticity in the brain. This project aims to determine how neuroplasticity – the brain’s ability to remodel and make new circuits – is controlled in both excitatory and inhibitory neurons. This capacity, vital for all cognitive functions, diminishes as people age. It is imperative to determine neuroplasticity’s mechanisms and how and why they change, but it is not known how both excitatory and inhibitory neurons contribute to neuroplasticity and how these dynamic alterations ....The control of neuroplasticity in the brain. This project aims to determine how neuroplasticity – the brain’s ability to remodel and make new circuits – is controlled in both excitatory and inhibitory neurons. This capacity, vital for all cognitive functions, diminishes as people age. It is imperative to determine neuroplasticity’s mechanisms and how and why they change, but it is not known how both excitatory and inhibitory neurons contribute to neuroplasticity and how these dynamic alterations are controlled. Understanding neuroplasticity is vital for learning, memory and healthy ageing throughout life.Read moreRead less
Inherited determinants of cancer aetiology. Family history of cancer is a strong risk factor for many cancers. This project will aim to identify inherited factors influencing risk of developing cancer and those factors influencing the course of the disease and outcomes.
Discovery Early Career Researcher Award - Grant ID: DE140100076
Funder
Australian Research Council
Funding Amount
$394,585.00
Summary
Mixing hot spots in the Southern Ocean: processes, parameterisations and climate impacts. The Southern Ocean plays a critical role in the uptake of heat and carbon dioxide from the atmosphere into the deep ocean. This uptake depends strongly on mixing processes due to ocean eddies, which are especially important in regions of steep topography, leading to localised mixing hot spots. These ocean eddies have scales of 10-100km and therefore can not be resolved in current global climate models. This ....Mixing hot spots in the Southern Ocean: processes, parameterisations and climate impacts. The Southern Ocean plays a critical role in the uptake of heat and carbon dioxide from the atmosphere into the deep ocean. This uptake depends strongly on mixing processes due to ocean eddies, which are especially important in regions of steep topography, leading to localised mixing hot spots. These ocean eddies have scales of 10-100km and therefore can not be resolved in current global climate models. This project will examine these mixing processes using a combination of observations and innovative modelling approaches. This knowledge will be used to improve the representation of eddy processes in state-of-the-art climate models, which will ultimately allow Australia to more effectively respond to the challenge of climate change.Read moreRead less
Identifying the specific structural features of metallothionein that regulate its ability to modulate astrogliosis. This project contributes directly to the Designated National Research Priority 2 and could potentially have a significant impact upon the broader Australian Community by identifying a novel and powerful therapeutic agent based upon metallothionein proteins with the ultimate aim of helping patients who have a brain injury or a neurodegenerative disease. It is important to note that ....Identifying the specific structural features of metallothionein that regulate its ability to modulate astrogliosis. This project contributes directly to the Designated National Research Priority 2 and could potentially have a significant impact upon the broader Australian Community by identifying a novel and powerful therapeutic agent based upon metallothionein proteins with the ultimate aim of helping patients who have a brain injury or a neurodegenerative disease. It is important to note that the partnership between UTAS and Bestenbalt LLC is a critical step in the development of these exciting research discoveries into commercially viable outcomes for the Australian Biotechnology Industry and the broader Australian community.Read moreRead less