Can Exercise Delay Transition To Active Therapy In Men With Low Grade Prostate Cancer? A Multi-Centre Randomized Controlled Trial.
Funder
National Health and Medical Research Council
Funding Amount
$604,429.00
Summary
Prostate cancer overdiagnosis is associated with increased rates of overtreatment and associated morbidity. Although nearly half of Australian men diagnosed with low risk prostate cancer are managed with active surveillance there are no established recommendations for slowing disease progression and delaying transition to active treatment. The proposed study would be the first to determine the efficacy of a comprehensive exercise program during active surveillance for prostate cancer.
Workplace Interventions To Reduce The Cost Of Neck Problems In Office Personnel
Funder
National Health and Medical Research Council
Funding Amount
$660,834.00
Summary
Neck pain in office workers is a major burden in industry in terms of lost productivity and personal suffering. This research will evaluate a novel intervention for the prevention and management of neck pain in computer users. The impact and value of neck specific exercises and best practice office ergonomics will be evaluated from the employers (productivity loss) and workers perspective (severity of neck pain). The findings will directly benefit future management of this significant health iss ....Neck pain in office workers is a major burden in industry in terms of lost productivity and personal suffering. This research will evaluate a novel intervention for the prevention and management of neck pain in computer users. The impact and value of neck specific exercises and best practice office ergonomics will be evaluated from the employers (productivity loss) and workers perspective (severity of neck pain). The findings will directly benefit future management of this significant health issue.Read moreRead less
Exercise As Medicine For Heart Failure: A Novel Intervention To Improve Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$665,585.00
Summary
Heart failure (HF) is a common, debilitating and expensive disease; prognosis remains poorer than for the most cancers. 30,000 Australians are diagnosed every year and 300,000 live with the HF, at an annual cost of ~$1Billion. Exercise training is effective therapy in HF, because it reverses many of the problems that contribute to the reduced lifespan and impaired quality of life of patients with HF. We will test an exciting new type of exercise that promising greater benefit, at lower risk.
The Impact Of Therapy On T-cell Recognition Of Mutated Tumour Neo-antigens
Funder
National Health and Medical Research Council
Funding Amount
$1,126,685.00
Summary
Cancer is caused by mutations which should be 'seen' and destroyed by the patients immune cells, similar to how immune cells protect us against viruses. But they don't. This grant will study how current cancer treatments help the immune cells 'see' these mutations. We will undertake these studies in the important cancers lung cancer and mesothelioma.
A Study Of Artemisinin Combination Therapy Given At Delivery To Prevent Postpartum Malaria And To Young Infants To Treat Uncomplicated Malaria
Funder
National Health and Medical Research Council
Funding Amount
$788,850.00
Summary
The proposed studies will investigate the preventive value of a course of combination antimalarial treatment at delivery in pregnant women in malarial areas. The transfer of this treatment into breast milk and to the suckling infant will be investigated since this may protect the infant against malaria but also cause drug-related side-effects. These data will be used, with a study of combination treatment in infants with malaria, to optimise dose regimens in this vulnerable group.
HABIT-ILE: A Randomised Trial Of Hand Arm Bimanual Intensive Training Including Lower Extremity Training For Children With Bilateral Cerebral Palsy
Funder
National Health and Medical Research Council
Funding Amount
$1,100,903.00
Summary
In Australia, 35,000 people have cerebral palsy, and between 60-70% experience difficulties with movement on both sides of their body. There are currently no effective interventions for children with bilateral CP to improve their ability to use their hands, walk and perform daily life tasks. We have promising data about a new intervention, called HABIT-ILE, which we will test in 80 children with cerebral palsy and compare results to usual care.
Enhancing Clinical Management Of Paediatric Malaria In Endemic Areas With Transmission Of Multiple Plasmodium Species
Funder
National Health and Medical Research Council
Funding Amount
$867,511.00
Summary
Malaria remains a major problem for children in developing countries especially where different types of the disease are common. This set of complementary studies, based at an established research site in PNG aims to develop new treatment strategies for childhood malaria. A novel method of giving medicine via a spray under the tongue for sick children before arrival at hospital and modified dosing schedules of an old drug used for treating parasites hidden in the liver will be studied.
Temporal Trends In The Incidence, Site And Survival Of Metastatic Breast Cancer In Australia
Funder
National Health and Medical Research Council
Funding Amount
$190,494.00
Summary
There have been major advances in breast cancer treatment over the last decade. This project will use information collected from the NSW cancer registry and hospitals to report on changes in the type and risk of breast cancer spread and survival for women with a new diagnosis of breast cancer before and after new treatments introduced since 2005. This information is essential for doctors to provide women with up-to-date information; and for planning appropriate health services and research.
Melanoma Mutation Profiling For Personalised Treatment
Funder
National Health and Medical Research Council
Funding Amount
$571,191.00
Summary
Melanoma is an aggressive skin cancer, and the leading cause of skin cancer related deaths. Disease spread is difficult to detect and extremely difficult to cure. This bleak clinical outcome is changing with the development of personalised therapies which include small molecule inhibitors to treat metastatic melanoma. Here we seek to identify the spectrum of mutations in patient tumours and circulating tumour cells for advanced personalised treatment.
REACH: Randomised Trial Of EArly Rehabilitation In Congenital Hemiplegia
Funder
National Health and Medical Research Council
Funding Amount
$972,777.00
Summary
Infants with asymmetric brain lesions are at high risk of congenital hemiplegia. This study compares modified CIMT to an equal dose of bimanual training in 150 infants recruited at 3-6 months. Both therapies will be parent-delivered supported by experienced clinicians. Outcomes include use of the impaired hand in bimanual tasks, cognitive and motor development at 12 and 24 months c.a. with measures of neural structure and functional connectivity at 24 months. Early interventions that attenuate