Optimising Exercise and Nutrition Throughout the Life Cycle. During the past decade the proportion of Australia's population aged 65 years and over has increased to 13% (2.7 million). During the same period, the proportion of the population aged 85 years and over has more than doubled and is now the fastest growing subpopulation in Australia. As the number of elderly persons continues to grow, sarcopenia-related conditions will have a dramatic and inevitable impact on the lives of all Australian ....Optimising Exercise and Nutrition Throughout the Life Cycle. During the past decade the proportion of Australia's population aged 65 years and over has increased to 13% (2.7 million). During the same period, the proportion of the population aged 85 years and over has more than doubled and is now the fastest growing subpopulation in Australia. As the number of elderly persons continues to grow, sarcopenia-related conditions will have a dramatic and inevitable impact on the lives of all Australians. The novel dietary protocols developed from the results of the studies undertaken in this proposal will translate into better treatment options for reversing age-dependent muscle degeneration. This is a critical first step for improving the standard of living for a large portion of Australian society.Read moreRead less
The efficacy of a referral and physical activity program for survivors of prostate cancer. Although survival rates of prostate cancer are approximately 83 per cent with earlier detection and improved treatment modalities, prostate cancer survivors are at an increased risk of dying from co-morbidities, which may be prevented or ameliorated through participation in physical activity. This project aims to establish an effective and sustainable referral and physical activity program to improve the ....The efficacy of a referral and physical activity program for survivors of prostate cancer. Although survival rates of prostate cancer are approximately 83 per cent with earlier detection and improved treatment modalities, prostate cancer survivors are at an increased risk of dying from co-morbidities, which may be prevented or ameliorated through participation in physical activity. This project aims to establish an effective and sustainable referral and physical activity program to improve the health outcomes of prostate cancer survivors by utilising the influence of clinicians in their delivery of information to patients. This concept of a referral and physical activity program has the potential to translate across all cancer tumour streams to reduce the physiological and psychological burden associated with living with cancer.Read moreRead less
Social Impact and Connection Outcomes Associated with Community Sport. Outcomes of social connection from community sport are widely touted and supported to exist. However, we know little about how social infrastructure actually delivers these benefits. It is difficult to understand and develop practices that organisations can use to maximise the outcomes of sport participation. This research aims to investigate how social infrastructure delivers social connection outcomes associated with commun ....Social Impact and Connection Outcomes Associated with Community Sport. Outcomes of social connection from community sport are widely touted and supported to exist. However, we know little about how social infrastructure actually delivers these benefits. It is difficult to understand and develop practices that organisations can use to maximise the outcomes of sport participation. This research aims to investigate how social infrastructure delivers social connection outcomes associated with community sport. Expected outcomes include novel practice based tools and guidance for community groups to enhance social connection outcomes and new understanding about the role of social infrastructure in enhancing community connection. Improved social connection is expected to improve resilience and community wellbeing.
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Effectiveness of Intervention Strategies to Promote Physical Activity Among Insufficiently Active Adults. This project will determine the cost-effectiveness of 2 types of physical activity (PA) interventions based around the workplace. 480 participants will be randomly assigned to PA intervention groups or controls. Interventions are either a (1) self-regulated, pedometer-based program or a (2) semi-structured, 40-day initiation to more moderately-vigorous PA. Both are designed to increase self- ....Effectiveness of Intervention Strategies to Promote Physical Activity Among Insufficiently Active Adults. This project will determine the cost-effectiveness of 2 types of physical activity (PA) interventions based around the workplace. 480 participants will be randomly assigned to PA intervention groups or controls. Interventions are either a (1) self-regulated, pedometer-based program or a (2) semi-structured, 40-day initiation to more moderately-vigorous PA. Both are designed to increase self-efficacy and impact on positive PA behaviours. Long-term, behavioural change and job-related outcomes will be evaluated by following participants for 12 months after the interventions.Read moreRead less
Cellular genomic approach to the pathogenesis of multiple sclerosis. This project compares the levels of gene usage in two important immune cell types between patients with multiple sclerosis and people who do not have the disease. It aims to identify the molecular basis for the disease, in order to identify new diagnostic, preventative and treatment options.
The psychological effects of wasting in Australian jockeys. It is well known that many jockeys engage in short-term, unhealthy cycles of weight loss and gain, known as 'wasting', to maintain consistent low riding-weight. The use of saunas is specially popular, with other known practices including food avoidance, laxative abuse, ingestion of diuretics and appetite suppressants, excessive exercise and self-induced vomiting. The adverse physiological effects of 'wasting' are well documented. This i ....The psychological effects of wasting in Australian jockeys. It is well known that many jockeys engage in short-term, unhealthy cycles of weight loss and gain, known as 'wasting', to maintain consistent low riding-weight. The use of saunas is specially popular, with other known practices including food avoidance, laxative abuse, ingestion of diuretics and appetite suppressants, excessive exercise and self-induced vomiting. The adverse physiological effects of 'wasting' are well documented. This investigation seeks to explore and describe the ways in which these pathogenic forms of weight control used the jockeys effect their psychological health. The primary outcome focus of the research is the formulation of recommendations for the adoption of healthy weight management practices by Australian jockeys that promote psychological well-being.Read moreRead less
Improving determinants of Australian sports talent identification and development: a multi-disciplinary approach. Sport is important to many Australians. Our sport successes enhance our national identity, generate community pride and attract mega sport events. Currently our sport talent identification and development (TID) systems have been surpassed by our international rivals who borrowed from and improved our knowledge. This project will help regain Australia's international advantage and aga ....Improving determinants of Australian sports talent identification and development: a multi-disciplinary approach. Sport is important to many Australians. Our sport successes enhance our national identity, generate community pride and attract mega sport events. Currently our sport talent identification and development (TID) systems have been surpassed by our international rivals who borrowed from and improved our knowledge. This project will help regain Australia's international advantage and again make Australian TID the international benchmark. Results will highlight the role of TID practices in improving recreational participation and maximising, attracting, developing and retaining sport talent. This will result in improved use of sports limited TID funding by providing greater understanding of factors that influence elite selection and sport development.Read moreRead less
The adoption and maintenance of physical activity in 25-45 year old sedentary females. This research project will investigate interventions based on proven elements of theories on the adoption and maintenance of increased physical activity and psychological well-being in sedentary women aged 25-45 years, who are at risk of remaining inactive. A longitudinal study will examine the efficacy of adoption and maintenance interventions that combine effective constructs identified in analysis of theori ....The adoption and maintenance of physical activity in 25-45 year old sedentary females. This research project will investigate interventions based on proven elements of theories on the adoption and maintenance of increased physical activity and psychological well-being in sedentary women aged 25-45 years, who are at risk of remaining inactive. A longitudinal study will examine the efficacy of adoption and maintenance interventions that combine effective constructs identified in analysis of theories. Effective intervention will promote current life-experience, healthy lifestyle in later life, and decrease risk of chronic ill health.Read moreRead less
Biophysical identification of natural human antibody targets. A natural human antibody, PAT-SM6, isolated using technology developed by the partner organisation (Patrys), offers promise as a therapy to reduce mortalities due to cancer, the leading cause of death in Australia. The novelty of the approach pioneered by Patrys is the direct production of human antibodies which avoids undesirable side effects associated with the use of antibodies containing non-human components. This project is to ....Biophysical identification of natural human antibody targets. A natural human antibody, PAT-SM6, isolated using technology developed by the partner organisation (Patrys), offers promise as a therapy to reduce mortalities due to cancer, the leading cause of death in Australia. The novelty of the approach pioneered by Patrys is the direct production of human antibodies which avoids undesirable side effects associated with the use of antibodies containing non-human components. This project is to discover the specificity of PAT-SM6 for proteins and protein complexes and how these interactions lead to tumour cell death. This work will enhance the effectiveness of human antibody therapies and help in the development of this fast growing area within the biotechnology industry in Australia.Read moreRead less
Bilateral Cochlear Implants for Children: Does a Second Implant Improve Language, Psychosocial and Other Outcomes? Severe-profound congenital hearing loss engenders significant costs to society. In 2005, specialised education cost -- on average $25,000 per child, loss of productivity cost -- $6.7 billion, and social security benefits were paid to approximately 129,000 individuals who were unemployed due to hearing loss. If bilateral cochlear implantation results in improved language, social dev ....Bilateral Cochlear Implants for Children: Does a Second Implant Improve Language, Psychosocial and Other Outcomes? Severe-profound congenital hearing loss engenders significant costs to society. In 2005, specialised education cost -- on average $25,000 per child, loss of productivity cost -- $6.7 billion, and social security benefits were paid to approximately 129,000 individuals who were unemployed due to hearing loss. If bilateral cochlear implantation results in improved language, social development, and academic outcomes, the community benefits arising will be greatly improved quality of life for these individuals and significant savings to society. In partnership with Cochlear Ltd, this study will provide some of the first data worldwide comparing the effects of an additional implant on language, social and educational outcomes.Read moreRead less