Discovering And Targeting Genes Regulating Skeletal Muscle Function, Metabolism, And Adaptations To Exercise Interventions
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
Muscle wasting and decreased in mitochondrial function due to ageing or lack of physical activity are associated with reduced quality of life. The overarching aim is to develop a unique research program focusing on targeting specific genes, and to discover novel genes regulating muscle wasting and mitochondrial (dis)function. I anticipate this approach to assist in the development of targeted and personalised prevention and therapy for diseases associated with muscle (dis)function.
Uncovering Sex Specific, Epigenetic Biomarkers Of Healthy Ageing For Targeted Exercise Interventions
Funder
National Health and Medical Research Council
Funding Amount
$1,449,800.00
Summary
The aged population accounts for a significant, and increasing, amount of Australia’s health budget. We aim to uncover novel molecular biomarkers that slow the ageing process and maintain good health for longer. We will use innovative DNA and protein analysis to study the molecular ‘clocks’ of young and old populations and to test whether exercise can slow the ageing process. This will underpin the development of evidence-based biomarkers to be used in personalised health interventions.
Mechanisms Of Induction And Progression Of Childhood Asthma: Investigations In A Mouse Model
Funder
National Health and Medical Research Council
Funding Amount
$517,586.00
Summary
This project investigates how certain respiratory viral infections in very young children might predispose to developing asthma, and how inflammation in the airways in asthma might then worsen. The experimental work, which will use unique mouse models developed in the laboratories of the chief investigators, will focus on changes in genes that control the pattern of immune response to allergens and that regulate the progression of inflammation.
Playing it Safe: Psychological Safety and Mental Health for Community Sport. At a time when over half of all Australians participate in organised sports it is critical to ensure that these environments are psychologically safe. The problem is that community sports clubs have no clear guidance on how to fulfil this substantial responsibility. There have been urgent calls for the development of psychological safety and mental health guidelines which have yet to be answered. This project will deliv ....Playing it Safe: Psychological Safety and Mental Health for Community Sport. At a time when over half of all Australians participate in organised sports it is critical to ensure that these environments are psychologically safe. The problem is that community sports clubs have no clear guidance on how to fulfil this substantial responsibility. There have been urgent calls for the development of psychological safety and mental health guidelines which have yet to be answered. This project will deliver the knowledge to underpin effective psychological safety and mental health guidelines for community sports with national impact. When implemented, this knowledge will help sports clubs to provide a psychologically safe environment, and promote the mental health and wellbeing of all Australians involved in organised sports.Read moreRead less
The Relationship Between Maternal And Infant Dietary Intake Of Fermentable Fibre, Gut Microbiota, Short Chain Fatty Acids And Allergic Disease And Asthma: A Population-derived Birth Cohort Study
Funder
National Health and Medical Research Council
Funding Amount
$871,700.00
Summary
The proposed study will involve the Barwon Infant Study (BIS) cohort of 1074 infants to provide the first systematic investigation of the hypotheses that the epidemic of allergic disease and asthma in many parts of the world relates to the paucity of fermentable fibre in the modern diet, and that the protective effect of fermentable fibre is mediated by changes in the organisms that colonise the gut and the metabolites that they produce.
Methylation Sensitive Genes And The Transition To Allergic Disease: A Twin Study
Funder
National Health and Medical Research Council
Funding Amount
$493,843.00
Summary
Australia has amongst the highest reported prevalence allergic conditions (including asthma) in the world. Despite this, little is known about how these conditions arise. Mounting evidence implicates environmentally induced disruption of the genetic blueprint via a process known as epigenetics. We are combining the strengths of a unique collection of identical twins where one of a pair is sensitive to house dust mite, with cutting edge genomics, to characterise the pathways leading to allergy in ....Australia has amongst the highest reported prevalence allergic conditions (including asthma) in the world. Despite this, little is known about how these conditions arise. Mounting evidence implicates environmentally induced disruption of the genetic blueprint via a process known as epigenetics. We are combining the strengths of a unique collection of identical twins where one of a pair is sensitive to house dust mite, with cutting edge genomics, to characterise the pathways leading to allergy in children.Read moreRead less
The effect of physical activity and a structured exercise program on the psychological and physical development of Australian primary school children. This study will explore the effects of early childhood physical activity on development. Our study will assess quantitatively the beneficial effects of exercise on personal and physical growth in young children in a non-intimidating way using a specifically designed exercise program.
Social Impact and Connection Outcomes Associated with Community Sport. Outcomes of social connection from community sport are widely touted and supported to exist. However, we know little about how social infrastructure actually delivers these benefits. It is difficult to understand and develop practices that organisations can use to maximise the outcomes of sport participation. This research aims to investigate how social infrastructure delivers social connection outcomes associated with commun ....Social Impact and Connection Outcomes Associated with Community Sport. Outcomes of social connection from community sport are widely touted and supported to exist. However, we know little about how social infrastructure actually delivers these benefits. It is difficult to understand and develop practices that organisations can use to maximise the outcomes of sport participation. This research aims to investigate how social infrastructure delivers social connection outcomes associated with community sport. Expected outcomes include novel practice based tools and guidance for community groups to enhance social connection outcomes and new understanding about the role of social infrastructure in enhancing community connection. Improved social connection is expected to improve resilience and community wellbeing.
Read moreRead less
Uncovering The Basis Of Inflammatory And Immunodeficiency Diseases
Funder
National Health and Medical Research Council
Funding Amount
$15,718,075.00
Summary
A world-class team from 3 institutions, spanning disciplines of clinical and experimental immunology, therapeutics, signalling and genetics, will identify how immune and inflammatory responses are controlled in both health and disease. The major outcomes of this work will be the generation of new knowledge, concepts and approaches to diagnose, prevent and treat the major human health problems of autoimmune diseases, inflammation, allergy and immunodeficiency.