Bioengineering self-assembly of innovative core-shell nanomaterials . This project aims to generate new knowledge in nanoscale bioengineering. It expects to develop a disruptive platform technology for design and manufacture of advanced nanomaterials to provide solutions for unmet needs in industry. It will explore an innovative bioengineering concept that merges biopolymer synthesis with virus-like particle self-assembly to produce innovative tunable core-shell nanomaterials. Expected outcomes ....Bioengineering self-assembly of innovative core-shell nanomaterials . This project aims to generate new knowledge in nanoscale bioengineering. It expects to develop a disruptive platform technology for design and manufacture of advanced nanomaterials to provide solutions for unmet needs in industry. It will explore an innovative bioengineering concept that merges biopolymer synthesis with virus-like particle self-assembly to produce innovative tunable core-shell nanomaterials. Expected outcomes are the development of advanced techniques for design and manufacture of innovate nanomaterials with enhanced stability and performance. This innovative platform technology for precision engineering of high-performance nanomaterials should provide significant benefits for biotechnological and agricultural industries.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100156
Funder
Australian Research Council
Funding Amount
$289,500.00
Summary
3D Two-Photon Nanoprinter for Advanced Multi-Functional Materials & Devices. The Nanoscribe Photonic Professional GT2 Two-Photon 3D Printer enables tailoring materials’ architecture at nanoscale. This results in unique optical, mechanical, electrical, chemical, biochemical, and acoustic properties enabling a wealth of cutting-edge research activities in variety of fields including mechanical/optical/electrical metamaterials, bioinspired hard/soft materials, biomaterials (e.g., structured cell-ti ....3D Two-Photon Nanoprinter for Advanced Multi-Functional Materials & Devices. The Nanoscribe Photonic Professional GT2 Two-Photon 3D Printer enables tailoring materials’ architecture at nanoscale. This results in unique optical, mechanical, electrical, chemical, biochemical, and acoustic properties enabling a wealth of cutting-edge research activities in variety of fields including mechanical/optical/electrical metamaterials, bioinspired hard/soft materials, biomaterials (e.g., structured cell-tissue interfaces), biomedical devices (implantable devices and drug-delivery systems), nanofluidics, and photonic crystals. In each of these fields, we will use GT2 to print variety of polymers, hydrogels, metals and ceramics, for example by printing polymer-derived nanoceramics that will be simultaneously strong and tough.Read moreRead less
Engineering nanoscale tools for cellular interrogation. The aim is to address fundamental hurdles to engineering seamless nanobiointerfaces between electroactive nanoscale tools and living cells. This is expected to allow efficient delivery of many bioactive cargo types into cells, intracellular sampling of cytosol contents, and probing of action potential, all at the cell—material interface. New, powerful, electroactive nanoscale tools that deliver precise spatio-temporal resolution and minimal ....Engineering nanoscale tools for cellular interrogation. The aim is to address fundamental hurdles to engineering seamless nanobiointerfaces between electroactive nanoscale tools and living cells. This is expected to allow efficient delivery of many bioactive cargo types into cells, intracellular sampling of cytosol contents, and probing of action potential, all at the cell—material interface. New, powerful, electroactive nanoscale tools that deliver precise spatio-temporal resolution and minimal invasiveness and perturbation are likely to transform ex-vivo cellular processes. The intended outcomes are crucial for maximising precision in engineering and implementing of ex-vivo cellular processes. Fundamental advances in knowledge may eventually be a platform for developing cell-based therapies.
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Highly Efficient Nanomotors for Autonomous Cell Recognition and Isolation. This project aims to develop next-generation self-driven nanomotors capable of long-range motion with highly controlled directionality for cell recognition, transportation and separation in complex biological environments, to allow autonomous and seamless cell sorting with high accuracy. The anticipated goal of this project is to advance the field of nanotechnology and advanced manufacturing with potential to support new ....Highly Efficient Nanomotors for Autonomous Cell Recognition and Isolation. This project aims to develop next-generation self-driven nanomotors capable of long-range motion with highly controlled directionality for cell recognition, transportation and separation in complex biological environments, to allow autonomous and seamless cell sorting with high accuracy. The anticipated goal of this project is to advance the field of nanotechnology and advanced manufacturing with potential to support new applications and to value-add Australia’s advanced manufacturing industry, presenting new opportunities for Australian MedTech industries with innovative, disruptive technologies to address its unique needs and to claim Australia’s position within the competitive global market.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210101666
Funder
Australian Research Council
Funding Amount
$395,588.00
Summary
Engineering nanoparticles with enhanced adhesion at the nano-bio interfaces. This project aims to develop a next-generation adhesive nanoparticle platform through in-depth understandings of nanoparticle interactions with bio-interfaces. This project expects to generate new knowledge in the multidisciplinary research field at nano-bio-interfaces by using a recently developed nano-colloidal probe technology, instructing the rational design of nanoparticles with enhanced interface adhesive properti ....Engineering nanoparticles with enhanced adhesion at the nano-bio interfaces. This project aims to develop a next-generation adhesive nanoparticle platform through in-depth understandings of nanoparticle interactions with bio-interfaces. This project expects to generate new knowledge in the multidisciplinary research field at nano-bio-interfaces by using a recently developed nano-colloidal probe technology, instructing the rational design of nanoparticles with enhanced interface adhesive properties. Expected outcomes include a family of adhesive nanoparticles designed for nanopesticide and animal feed applications, with the potential to deliver valuable intellectual property of commercial interest and economic benefit through technology advancement.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150101212
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
In-situ Atomic-scale Deformation Mechanism of ultrafine Nanocrystalline Pt. Understanding the deformation of nanocrystalline (NC) metals is crucial for their practical application. So far, the deformation mechanism of ultrafine NC metals with grain size below 15 nanometre has been predicted by simulations which need to be verified experimentally. Using different in situ transmission electron microscopy deformation approaches, this project aims to determine deformation mechanisms of ultrafine NC ....In-situ Atomic-scale Deformation Mechanism of ultrafine Nanocrystalline Pt. Understanding the deformation of nanocrystalline (NC) metals is crucial for their practical application. So far, the deformation mechanism of ultrafine NC metals with grain size below 15 nanometre has been predicted by simulations which need to be verified experimentally. Using different in situ transmission electron microscopy deformation approaches, this project aims to determine deformation mechanisms of ultrafine NC platinum (Pt) at atomic-scale and to clarify how the deformation behaviour affects mechanical properties. The expected outcomes will advance the knowledge base in ultrafine NC metals and will provide guidance for developing advanced metallic materials with high strength/ductility that are the backbone for developing flexible and bendable devices.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100040
Funder
Australian Research Council
Funding Amount
$330,000.00
Summary
Advanced capabilities for surface engineering and nanolithography . Advanced capabilities for surface engineering and nanolithography: This project will establish a facility for atomic layer deposition and nanolithography. Strong fabrication and engineering capabilities are key in keeping interdisciplinary research highly competitive. The applications of these cutting-edge surface nanoengineering technologies are enormous and include: development of new materials with new properties for sensing, ....Advanced capabilities for surface engineering and nanolithography . Advanced capabilities for surface engineering and nanolithography: This project will establish a facility for atomic layer deposition and nanolithography. Strong fabrication and engineering capabilities are key in keeping interdisciplinary research highly competitive. The applications of these cutting-edge surface nanoengineering technologies are enormous and include: development of new materials with new properties for sensing, biosensing, optical, photonic, electronic and medical devices, new metamaterials, solar cell, energy production and environmental protection.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100030
Funder
Australian Research Council
Funding Amount
$980,000.00
Summary
Returning Western Australian characterisation capabilities to the cutting edge: high resolution analytical transmission electron microscopy. From the design of future electronic devices to understanding the formation of valuable deposits of gold and iron, the atomic scale structure and composition of materials plays an important role. The electron microscope will aid internationally-recognised WA-based groups conducting high impact research underpinning the Australian economy.
Protein Structural-Dynamics at Solid Surfaces: Beyond Static Snapshots. The project will use High-Speed Atomic Force Microscopy to directly visualize single proteins in ‘action’ with surfaces, revealing their dynamics at unprecedented combined structural and temporal resolution in liquid. Such characterization moves beyond static ‘snapshots’ of protein structure, toward the dynamic changes in protein conformation that will enable new exploration of key biological processes at liquid-solid interf ....Protein Structural-Dynamics at Solid Surfaces: Beyond Static Snapshots. The project will use High-Speed Atomic Force Microscopy to directly visualize single proteins in ‘action’ with surfaces, revealing their dynamics at unprecedented combined structural and temporal resolution in liquid. Such characterization moves beyond static ‘snapshots’ of protein structure, toward the dynamic changes in protein conformation that will enable new exploration of key biological processes at liquid-solid interfaces. New fundamental discoveries will have an impact on technologies such as medical device coatings, biomaterials, biosensors, microfluidics devices, protein purification and diagnostics assays that are critically dependent on the biological function of adsorbed or immobilized proteins.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100234
Funder
Australian Research Council
Funding Amount
$155,000.00
Summary
Facility for Nanometer Scale Microscopy, Characterization, and Fabrication. Facility for nanometre-scale microscopy, characterisation, and fabrication:
This project aims to create a collaborative research facility for the microscopy and characterisation of nanometre structured devices and materials, enabling researchers to visualise and quantify the topography, chemical composition and structure of samples with a resolution approaching the atomic scale. A WiTek Alpha300SR microscope is capable ....Facility for Nanometer Scale Microscopy, Characterization, and Fabrication. Facility for nanometre-scale microscopy, characterisation, and fabrication:
This project aims to create a collaborative research facility for the microscopy and characterisation of nanometre structured devices and materials, enabling researchers to visualise and quantify the topography, chemical composition and structure of samples with a resolution approaching the atomic scale. A WiTek Alpha300SR microscope is capable of simultaneous atomic force microscopy, near-field scanning optical microscopy, photocurrent mapping, and Raman spectroscopy. These capabilities would allow the mapping of topography and chemical composition, response to optical stimulus, and the structure of materials in 3-D with nanometre-scale resolution on surfaces. This instrument would support research in areas such as organic photovoltaics, nanofabrication, polymer electronics, ionic fluids, functional interfaces, and thermionic devices.Read moreRead less