Magnetofection In An Oscillating Magnetic Field. The success of genetic engineering is largely dependent on the ability of transfection agents to deliver genes. Low transfection efficiency is now widely recognised as a critical bottleneck to successful gene delivery. The recent emphasis on the development of nanoscale delivery agents has led to new physics and chemistry-based techniques, which take advantage of charge interactions and energetic processes. This multidisciplinary project aims to a ....Magnetofection In An Oscillating Magnetic Field. The success of genetic engineering is largely dependent on the ability of transfection agents to deliver genes. Low transfection efficiency is now widely recognised as a critical bottleneck to successful gene delivery. The recent emphasis on the development of nanoscale delivery agents has led to new physics and chemistry-based techniques, which take advantage of charge interactions and energetic processes. This multidisciplinary project aims to address this highly significant problem by developing a novel methodology to manipulate nanoparticles under the influence of an oscillating magnetic field to achieve high transfection efficiencies in a highly relevant model of epigenetic reprogramming.Read moreRead less
Establishing Design Principles Of Polymers For Intracellular Delivery . Engineered polymers have played a central role in the field of bionanotechnology by enabling targeted nanoscale cell interactions. Progress in the field of intracellular delivery is currently affected by a major bottleneck due to the absence of effective polymers that is applicable across the range of bimolecular cargoes. In essence depending on the type of cargo: DNA, RNA or protien, the polymer needs programmability. The l ....Establishing Design Principles Of Polymers For Intracellular Delivery . Engineered polymers have played a central role in the field of bionanotechnology by enabling targeted nanoscale cell interactions. Progress in the field of intracellular delivery is currently affected by a major bottleneck due to the absence of effective polymers that is applicable across the range of bimolecular cargoes. In essence depending on the type of cargo: DNA, RNA or protien, the polymer needs programmability. The limited tunability of traditional polymers agents makes them unsuitable for this particular application. The multidisciplinary project addresses this significant problem by engineering novel sequences of defined polymer based nanoscale agents to achieve efficient delivery in cells.Read moreRead less
A southern hemisphere ground station for the Atomic Clock Ensemble in Space mission. Australia is aiming for membership in the high-profile space mission involving atomic clocks on-board the International Space Station. The mission will test aspects of special and general relativity, searching for tell-tale signs of new physics. This project will construct an atomic fountain clock and install a microwave-satellite link to meet the goal.
Use of Gas Expanded Liquids to Facilitate Process Intensification. The aim of this research is the utilisation of gas expanded liquids (GXLs) in technology platforms based on the principles of process intensification (PI). In order to facilitate the attainment of project objectives a comprehensive investigation of the fundamental properties of GXLs, and their interactions is proposed. A significant component of the programme is expected to be to use the knowledge obtained to facilitate the devel ....Use of Gas Expanded Liquids to Facilitate Process Intensification. The aim of this research is the utilisation of gas expanded liquids (GXLs) in technology platforms based on the principles of process intensification (PI). In order to facilitate the attainment of project objectives a comprehensive investigation of the fundamental properties of GXLs, and their interactions is proposed. A significant component of the programme is expected to be to use the knowledge obtained to facilitate the development of scale-up protocol for PI based methodologies, with particular emphasis on the production of biomaterials. GXLs technology is frontier technology with regard to the biomaterials sector.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH130200025
Funder
Australian Research Council
Funding Amount
$2,181,756.00
Summary
ARC Research Hub for transforming waste directly in cost-effective green manufacturing. ARC Research Hub for transforming waste directly in cost-effective green manufacturing. This Research Hub aims to create a unique opportunity for completely different industries to come together, with a common goal of creating value from mixed plastic and glass waste in manufacturing. Starting with fundamental investigations of the transformation behaviour of waste materials under high temperature conditions, ....ARC Research Hub for transforming waste directly in cost-effective green manufacturing. ARC Research Hub for transforming waste directly in cost-effective green manufacturing. This Research Hub aims to create a unique opportunity for completely different industries to come together, with a common goal of creating value from mixed plastic and glass waste in manufacturing. Starting with fundamental investigations of the transformation behaviour of waste materials under high temperature conditions, the hub will focus on developing scalable solutions for its manufacturing partners towards reducing the consumption of primary resources while simultaneously diverting waste streams from landfill. Additionally, the potential of using such transformations to yield improved products such as wear-resistant grinding media and light-weight building materials will be investigated to enhance Australian manufacturing.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC210100056
Funder
Australian Research Council
Funding Amount
$3,975,864.00
Summary
ARC Training Centre for Next-Gen Technologies in Biomedical Analysis . The Centre for Next-Gen Technologies in Biomedical Analysis will deliver workforce trained in the development of transformative technologies that will rapidly expand the Australian pharmaceutical, diagnostic and defence sector. The university-industry partnership will increase Australia’s manufacturing capability by fast tracking screening, by integrating 3D printing, advanced sensing, big data analytics, machine learning an ....ARC Training Centre for Next-Gen Technologies in Biomedical Analysis . The Centre for Next-Gen Technologies in Biomedical Analysis will deliver workforce trained in the development of transformative technologies that will rapidly expand the Australian pharmaceutical, diagnostic and defence sector. The university-industry partnership will increase Australia’s manufacturing capability by fast tracking screening, by integrating 3D printing, advanced sensing, big data analytics, machine learning and artificial intelligence for the delivery of optimal solutions in diagnosis, treatment and wellbeing. The centre will deliver training in Industry 4.0 skills which will boost early-stage scale-up and accelerate the sector’s supply chain, which is pivotal for the Australian industries to maintain a competitive edge. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100100
Funder
Australian Research Council
Funding Amount
$440,000.00
Summary
Cytometer by Time of Flight (CyTOF): A New Paradigm in Cytometry. Cytometer by Time of Flight (CyTOF) - a new paradigm in cytometry: The acquisition of a Cytometer by Time of Flight will allow multiparametric characterisation of biological systems and quantitative analysis of nano-bio interactions at the single cell level. The convergence of nanotechnology with biomedicine offers unprecedented opportunities for biological applications, including targeted therapeutics. One of the major challenges ....Cytometer by Time of Flight (CyTOF): A New Paradigm in Cytometry. Cytometer by Time of Flight (CyTOF) - a new paradigm in cytometry: The acquisition of a Cytometer by Time of Flight will allow multiparametric characterisation of biological systems and quantitative analysis of nano-bio interactions at the single cell level. The convergence of nanotechnology with biomedicine offers unprecedented opportunities for biological applications, including targeted therapeutics. One of the major challenges lies in understanding the complex interactions between nanoengineered materials and biological systems.Read moreRead less
Establishing nanoscale design principles for non-viral genome engineering. This project aims to develop a bio-nanotechnology platform for non-viral genome engineering using dendronised polymers. The project will advance both fundamental and practical knowledge at the forefront of nanotechnology and cell biology, whilst providing training to the research community. Outcomes from the project will also provide significant benefits, such as positioning Australia at the forefront of genome engineerin ....Establishing nanoscale design principles for non-viral genome engineering. This project aims to develop a bio-nanotechnology platform for non-viral genome engineering using dendronised polymers. The project will advance both fundamental and practical knowledge at the forefront of nanotechnology and cell biology, whilst providing training to the research community. Outcomes from the project will also provide significant benefits, such as positioning Australia at the forefront of genome engineering.Read moreRead less
Meta-microscopy of insect tissue: How nature grows bicontinuous nanosolids. Several butterfly species grow a complex nano-sculptured matrix whose chiral network structure confers remarkable optical properties, including jewel-like reflections. The formation process remains mysterious and a spectacular case of bottom-up self-assembly at far larger scales than accessible in the lab. The project aims to decipher this process, by (a) tomography of a species where arrested growth sites represent time ....Meta-microscopy of insect tissue: How nature grows bicontinuous nanosolids. Several butterfly species grow a complex nano-sculptured matrix whose chiral network structure confers remarkable optical properties, including jewel-like reflections. The formation process remains mysterious and a spectacular case of bottom-up self-assembly at far larger scales than accessible in the lab. The project aims to decipher this process, by (a) tomography of a species where arrested growth sites represent time-frozen snapshots of the development, and (b) by a combination of micron-resolved in-vivo microscopy of a developing butterfly wing with a growth model to infer nanometer-scale information. This insight will lead to blueprints for self-assembly strategies and shed light on function and form of inner-cellular membranes. Read moreRead less
Nanoscale liquid interfaces: properties and molecular sensitivity. Challenges facing society in health and environment need new molecular measurements that are accurate, sensitive and fast. By use of nanoscale oil-water junctions, the project will develop new chemical and biological sensors that hold great promise for solving molecular measurement problems, including the ability to detect single molecules.