Trapping and Watching Biomolecular Complexes near Nanopores. This project aims to develop a technology to trap and interrogate nanosized molecular complexes in their natural state. Nanosized complexes in water provide the core machinery of biological systems and require detailed understanding to help unravel fundamental biological mechanisms. A prototype of a methodology has been developed to trap and interrogate nanoscaled objects as small as 190 nanometres within a nanopore device. By performi ....Trapping and Watching Biomolecular Complexes near Nanopores. This project aims to develop a technology to trap and interrogate nanosized molecular complexes in their natural state. Nanosized complexes in water provide the core machinery of biological systems and require detailed understanding to help unravel fundamental biological mechanisms. A prototype of a methodology has been developed to trap and interrogate nanoscaled objects as small as 190 nanometres within a nanopore device. By performing research to fully understand, miniaturise and develop this method further, this project aims to enable the quantitative observation of nanoscaled biological machinery involved in cell-to-cell communication and DNA unfolding. Such a technology platform may have applications in areas such as biology, biotechnology and advanced materials.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100986
Funder
Australian Research Council
Funding Amount
$401,000.00
Summary
High-performance, portable ion-mobility surface-acoustic wave spectrometry. This project aims to develop a high-performance, cost-effective, palm-portable differential ion mobility spectrometer for universal chemical analysis that operates at atmospheric pressure and consumes minimal power. A significant problem in current analytical chemistry is the lack of rapid and cost-effective methods that can be used in the field for analysis of many different chemical species of environmental and biologi ....High-performance, portable ion-mobility surface-acoustic wave spectrometry. This project aims to develop a high-performance, cost-effective, palm-portable differential ion mobility spectrometer for universal chemical analysis that operates at atmospheric pressure and consumes minimal power. A significant problem in current analytical chemistry is the lack of rapid and cost-effective methods that can be used in the field for analysis of many different chemical species of environmental and biological importance. The project expects to enable the rapid and simultaneous separation and detection of many different ions from complex mixtures with high selectivity and sensitivity. The spectrometer can be implemented in the field for various applications such as atmospheric monitoring, disease diagnosis and chemical weapons detection.Read moreRead less
The development of novel and tunable metamaterials. Metamaterials are designed materials with properties that cannot be found in nature. This project uses a new disruptive design that allows broadband metamaterials to be made using mass production techniques. The design opens up a range of new applications in environmental and medical sensing, improved security screening and active devices.
Engineering floating liquid marbles for three-dimensional cell cultures. This project aims to understand the physics of three-dimensional cell cultures in a liquid marble floating on a liquid free surface. New methodology developed can produce these cell cultures without using matrices or scaffolds and with run-times well beyond existing technologies. This methodology closely mimics a normal in-vivo environment and produces spheroids needed in cell transplantation therapies. This project will re ....Engineering floating liquid marbles for three-dimensional cell cultures. This project aims to understand the physics of three-dimensional cell cultures in a liquid marble floating on a liquid free surface. New methodology developed can produce these cell cultures without using matrices or scaffolds and with run-times well beyond existing technologies. This methodology closely mimics a normal in-vivo environment and produces spheroids needed in cell transplantation therapies. This project will resolve uncertainties in the underlying phenomena. The expected outcome should support future high quality cell cultures suitable for transplantation therapies.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190101513
Funder
Australian Research Council
Funding Amount
$390,000.00
Summary
Ant-inspired rules for self-assembly in swarm robotics and complex systems. This project aims to investigate how ants use self-assembly to build bridges and chains, joining their bodies using simple rules at the individual-level to build complex structures at the group-level. The long-standing conceptual gap between these two organisational levels will be addressed using innovative animal behaviour experiments, computer modelling and embodied testing of theory in a robot swarm. The expected outc ....Ant-inspired rules for self-assembly in swarm robotics and complex systems. This project aims to investigate how ants use self-assembly to build bridges and chains, joining their bodies using simple rules at the individual-level to build complex structures at the group-level. The long-standing conceptual gap between these two organisational levels will be addressed using innovative animal behaviour experiments, computer modelling and embodied testing of theory in a robot swarm. The expected outcomes of the project include new models for understanding self-assembly in complex systems and new control algorithms for robot swarms. The project should provide significant benefits such as programming to allow robot swarms to autonomously self-assemble useful structures that enhance their operational capabilities.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100736
Funder
Australian Research Council
Funding Amount
$362,446.00
Summary
High performing multifunctional silicon nanomaterials for bio-applications. This project aims to develop high-performance, multifunctional silicon nanomaterials, and to understand their physicochemical properties for bio-imaging. A range of high-quality multifunctional silicon-based bio-probes with novel fluorescent and magnetic properties will be developed for enhancing bio-imaging. The outcomes of the project will further strengthen Australia’s leading position in the targeted areas of Advance ....High performing multifunctional silicon nanomaterials for bio-applications. This project aims to develop high-performance, multifunctional silicon nanomaterials, and to understand their physicochemical properties for bio-imaging. A range of high-quality multifunctional silicon-based bio-probes with novel fluorescent and magnetic properties will be developed for enhancing bio-imaging. The outcomes of the project will further strengthen Australia’s leading position in the targeted areas of Advanced Materials and Nanotechnology.Read moreRead less
Integrating biologically-inspired auditory models into deep learning. This project aims to discover how a biologically inspired auditory model can be tightly integrated into a state-of-the-art deep learning speech processing framework, to model, design and verify a deep learning based auditory model. Voice-based technologies, ranging from cochlear implants to smart homes, are growing at a rapid pace and speech interfaces are being integrated with all aspects of our lives. However, there is a gro ....Integrating biologically-inspired auditory models into deep learning. This project aims to discover how a biologically inspired auditory model can be tightly integrated into a state-of-the-art deep learning speech processing framework, to model, design and verify a deep learning based auditory model. Voice-based technologies, ranging from cochlear implants to smart homes, are growing at a rapid pace and speech interfaces are being integrated with all aspects of our lives. However, there is a growing demand to improve these voice-enabled services, making them more secure and less open to cyber-crime attack by unauthorised users. The project is expected to improve techniques for modelling and automatic processing of speech and audio signals, which should provide significant benefits, including improved voice biometrics and cochlear implants.Read moreRead less
The role of central carbon metabolism in cell cycle control in bacteria. Bacteria are simple organisms, yet we still do not understand how they coordinate their growth with their reproduction so faithfully, generation after generation, to produce viable newborn cells. The new discovery of a link between the food bacteria eat and the first stage of their cell division now provides the opportunity to elucidate how bacteria 'measure' their energy production to control their proliferation. This proj ....The role of central carbon metabolism in cell cycle control in bacteria. Bacteria are simple organisms, yet we still do not understand how they coordinate their growth with their reproduction so faithfully, generation after generation, to produce viable newborn cells. The new discovery of a link between the food bacteria eat and the first stage of their cell division now provides the opportunity to elucidate how bacteria 'measure' their energy production to control their proliferation. This project combines the latest technology with complementary expertise in bacterial cell division and metabolism. This should identify the mechanism that integrates these fundamental pathways in bacteria, crucial to both their survival and ability to cause infection.Read moreRead less
Identifying how bacterial cells find their middle: a new perspective. This project will reveal new information about how bacterial cells divide with high precision to ensure that each newborn cell contains the correct genetic material. The research uses frontier techniques, provides innovative training to young Australian researchers, and will identify new ways to treat infections caused by bacteria.
Enhance ferromagnetic ordering by exchange coupling and defect engineering. This project aims to achieve room temperature ferromagnetism in two-dimensional materials via magnetic element doping and defect and interface engineering. Achieving high spin polarisation, high spin diffusion length and effective spin manipulation, the pre-requisites for functional spintronics devices, makes research into two-dimensional materials for spintronics applications difficult. This project could establish a so ....Enhance ferromagnetic ordering by exchange coupling and defect engineering. This project aims to achieve room temperature ferromagnetism in two-dimensional materials via magnetic element doping and defect and interface engineering. Achieving high spin polarisation, high spin diffusion length and effective spin manipulation, the pre-requisites for functional spintronics devices, makes research into two-dimensional materials for spintronics applications difficult. This project could establish a solid foundation for realising qualified spintronics materials for spintronics devices. The expected outcomes are low power, high speed, spintronics devices, enhancing Australia’s strength in spintronics research.Read moreRead less