Magnetofection In An Oscillating Magnetic Field. The success of genetic engineering is largely dependent on the ability of transfection agents to deliver genes. Low transfection efficiency is now widely recognised as a critical bottleneck to successful gene delivery. The recent emphasis on the development of nanoscale delivery agents has led to new physics and chemistry-based techniques, which take advantage of charge interactions and energetic processes. This multidisciplinary project aims to a ....Magnetofection In An Oscillating Magnetic Field. The success of genetic engineering is largely dependent on the ability of transfection agents to deliver genes. Low transfection efficiency is now widely recognised as a critical bottleneck to successful gene delivery. The recent emphasis on the development of nanoscale delivery agents has led to new physics and chemistry-based techniques, which take advantage of charge interactions and energetic processes. This multidisciplinary project aims to address this highly significant problem by developing a novel methodology to manipulate nanoparticles under the influence of an oscillating magnetic field to achieve high transfection efficiencies in a highly relevant model of epigenetic reprogramming.Read moreRead less
Establishing Design Principles Of Polymers For Intracellular Delivery . Engineered polymers have played a central role in the field of bionanotechnology by enabling targeted nanoscale cell interactions. Progress in the field of intracellular delivery is currently affected by a major bottleneck due to the absence of effective polymers that is applicable across the range of bimolecular cargoes. In essence depending on the type of cargo: DNA, RNA or protien, the polymer needs programmability. The l ....Establishing Design Principles Of Polymers For Intracellular Delivery . Engineered polymers have played a central role in the field of bionanotechnology by enabling targeted nanoscale cell interactions. Progress in the field of intracellular delivery is currently affected by a major bottleneck due to the absence of effective polymers that is applicable across the range of bimolecular cargoes. In essence depending on the type of cargo: DNA, RNA or protien, the polymer needs programmability. The limited tunability of traditional polymers agents makes them unsuitable for this particular application. The multidisciplinary project addresses this significant problem by engineering novel sequences of defined polymer based nanoscale agents to achieve efficient delivery in cells.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100100
Funder
Australian Research Council
Funding Amount
$440,000.00
Summary
Cytometer by Time of Flight (CyTOF): A New Paradigm in Cytometry. Cytometer by Time of Flight (CyTOF) - a new paradigm in cytometry: The acquisition of a Cytometer by Time of Flight will allow multiparametric characterisation of biological systems and quantitative analysis of nano-bio interactions at the single cell level. The convergence of nanotechnology with biomedicine offers unprecedented opportunities for biological applications, including targeted therapeutics. One of the major challenges ....Cytometer by Time of Flight (CyTOF): A New Paradigm in Cytometry. Cytometer by Time of Flight (CyTOF) - a new paradigm in cytometry: The acquisition of a Cytometer by Time of Flight will allow multiparametric characterisation of biological systems and quantitative analysis of nano-bio interactions at the single cell level. The convergence of nanotechnology with biomedicine offers unprecedented opportunities for biological applications, including targeted therapeutics. One of the major challenges lies in understanding the complex interactions between nanoengineered materials and biological systems.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100032
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Advanced Multifunctional Electro-Opto-Magneto-Mechanical Analysis Platform. This project aims to build an advanced multi-functional Electro-Opto-Magneto-Mechanical analysis platform for characterizing nanomaterials and micro-/nano-scale devices. This platform expects to provide rich and unique characterization capabilities (electrical, optical, magnetic and mechanical) for hybrid devices with low temperature and high vacuum environment. The expected outcomes include multidisciplinary research co ....Advanced Multifunctional Electro-Opto-Magneto-Mechanical Analysis Platform. This project aims to build an advanced multi-functional Electro-Opto-Magneto-Mechanical analysis platform for characterizing nanomaterials and micro-/nano-scale devices. This platform expects to provide rich and unique characterization capabilities (electrical, optical, magnetic and mechanical) for hybrid devices with low temperature and high vacuum environment. The expected outcomes include multidisciplinary research collaborations and a wide range of next-generation technologies including non-invasive medical instruments, wearable devices, communication, quantum information systems and energy storage solutions. This should enable local design and construction of hybrid devices and advance the growth of local high-technology industries.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100056
Funder
Australian Research Council
Funding Amount
$621,198.00
Summary
High-frequency ultrasound and photoacoustic imaging for Western Australia. This project aims to obtain a small animal, high-frequency ultrasound and photoacoustic imaging instrument, to be placed in the University of Western Australia's Centre for Microscopy, Characterisation and Analysis. As a node of the National Imaging Facility, this infrastructure will result in enhanced capacity for fundamental, interdisciplinary, biological, and bionanotechnology research in Western Australia, and enable ....High-frequency ultrasound and photoacoustic imaging for Western Australia. This project aims to obtain a small animal, high-frequency ultrasound and photoacoustic imaging instrument, to be placed in the University of Western Australia's Centre for Microscopy, Characterisation and Analysis. As a node of the National Imaging Facility, this infrastructure will result in enhanced capacity for fundamental, interdisciplinary, biological, and bionanotechnology research in Western Australia, and enable pursuit of projects previously only possible either interstate or internationally. New capacity in small animal in-vivo imaging will generate knowledge in biology, feeding into such areas as species conservation and reproductive health, and intellectual property and commercial opportunity in areas such as medical imaging and theranostics.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100174
Funder
Australian Research Council
Funding Amount
$425,000.00
Summary
X-Ray Nanolithography Facility: Towards the ultimate resolution. This Project aims to address the need for precise and scalable nanoscale fabrication by establishing a synchrotron-based X-Ray Nanolithography Facility. This Project expects to generate new knowledge in the areas of advanced manufacturing and nanotechnology using an innovative approach that combines coherent lithography and coherent imaging metrology. Expected outcomes of this project include an internationally unique, nationally ....X-Ray Nanolithography Facility: Towards the ultimate resolution. This Project aims to address the need for precise and scalable nanoscale fabrication by establishing a synchrotron-based X-Ray Nanolithography Facility. This Project expects to generate new knowledge in the areas of advanced manufacturing and nanotechnology using an innovative approach that combines coherent lithography and coherent imaging metrology. Expected outcomes of this project include an internationally unique, nationally accessible capability for manufacturing at the nanoscale and for industry-driven collaborative research. This should provide significant benefits across fields that aim to harness the unique properties of engineered nanomaterials to greatly enhance the technologies required to solve global challenges.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100003
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
3D Nanofabrication and Nanocharacterisation facility. This project aims to establish a revolutionary nanoscale fabrication and characterisation facility in Australia. The facility is an angle-based nanoscale etching system with integrated chemical analysis capabilities and will be the first instrument of its kind in Australia. The facility will enable unprecedented fabrication and characterisation of 3D nanostructures and new device geometries from semiconductors, oxides and metals that underpin ....3D Nanofabrication and Nanocharacterisation facility. This project aims to establish a revolutionary nanoscale fabrication and characterisation facility in Australia. The facility is an angle-based nanoscale etching system with integrated chemical analysis capabilities and will be the first instrument of its kind in Australia. The facility will enable unprecedented fabrication and characterisation of 3D nanostructures and new device geometries from semiconductors, oxides and metals that underpin modern nanoelectronics for innovative energy, nano-optical and quantum device applications. This unique equipment will facilitate breakthrough discoveries in nanomaterials, and foster collaborations amongst Australian researchers to accelerate industry in advanced nanodevice technologies.Read moreRead less
Inorganic/organic Hybrids for flexible thermoelectric generators. Flexible thermoelectric generators can directly harvest electricity from body heat, offering a new technology for wearable electronics, but their unsatisfied performance limits their applications. This project aims to design high-efficient and mechanically robust flexible thermoelectric devices based on novel hybrids with quantum dots and conducting polymers as key components. The key breakthrough is to establish unique devices wi ....Inorganic/organic Hybrids for flexible thermoelectric generators. Flexible thermoelectric generators can directly harvest electricity from body heat, offering a new technology for wearable electronics, but their unsatisfied performance limits their applications. This project aims to design high-efficient and mechanically robust flexible thermoelectric devices based on novel hybrids with quantum dots and conducting polymers as key components. The key breakthrough is to establish unique devices with record-high thermoelectric efficiency and to illustrate the underlying mechanisms for searching new-type flexible thermoelectrics. The expected outcomes will lead to innovative technology for energy conversion and advanced manufacturing and place Australia at the forefront of energy and manufacturing fields.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100146
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
Multiphoton confocal microscope for high-speed, deep tissue imaging and multimodal nanoscale characterisation. This facility will provide the ability to optically section deep nanoparticles, cells, tissues and whole animals at high speed with unsurpassed spatial resolution at the atomic level. It will give biomedical, physical and life scientists and materials engineers the opportunity to image a range of dynamic processes and reconstruct these in three dimensions for the first time.
Electrostatic catalysis from single-molecule events to macroscopic systems. Electrostatics has important applications in day-to-day technologies, from recycling plastics to photocopying, but the exploration of how static charges affect chemical bonds and bonding is still in its infancy. This project aims to demonstrate the experimental links between the magnitude and polarity of an external electric field and chemical rates, expanding our understanding of chemical reactivity and transforming our ....Electrostatic catalysis from single-molecule events to macroscopic systems. Electrostatics has important applications in day-to-day technologies, from recycling plastics to photocopying, but the exploration of how static charges affect chemical bonds and bonding is still in its infancy. This project aims to demonstrate the experimental links between the magnitude and polarity of an external electric field and chemical rates, expanding our understanding of chemical reactivity and transforming our view of catalysis. By investigating the role of static electricity over systems selected from different sub-disciplines of chemistry, the project will derive the ground and selection rules for reactivity and selectivity by electrostatics. The project is expected to show that for chemical reactions of practical and conceptual value a specific catalyst can be replaced by a generic electric field stimulus, an invisible catalyst, enabling cleaner and cheaper opportunities that current technologies cannot fulfil.Read moreRead less