Local reoptimization for turbocharging heuristics. Theoretical computer science has up until now had little impact on the design of effective heuristics. While data sets may be large, significant structure is almost always present and important to take into account when designing algorithms. Parameterised complexity considers the underlying structure by parameterising not only on the size of the input but also on structural parameters. This project aims to take advantage of the many opportunitie ....Local reoptimization for turbocharging heuristics. Theoretical computer science has up until now had little impact on the design of effective heuristics. While data sets may be large, significant structure is almost always present and important to take into account when designing algorithms. Parameterised complexity considers the underlying structure by parameterising not only on the size of the input but also on structural parameters. This project aims to take advantage of the many opportunities for new theories in the design of new heuristics and in turbocharging existing heuristics for computationally hard problems.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100117
Funder
Australian Research Council
Funding Amount
$1,275,000.00
Summary
A platform consortium for integrated 'systems-omics' research. The proposal aims to establish a multi-institutional integrated ‘systems-omics’ platform across two of Victoria’s leading research universities, and associated research institutes. The platform will consist of two cutting edge ultra-high resolution mass spectrometers (i) a Thermo Scientific Orbitrap Fusion LUMOS for rapid and comprehensive metabolomic profiling and detailed structural characterization, located at La Trobe University ....A platform consortium for integrated 'systems-omics' research. The proposal aims to establish a multi-institutional integrated ‘systems-omics’ platform across two of Victoria’s leading research universities, and associated research institutes. The platform will consist of two cutting edge ultra-high resolution mass spectrometers (i) a Thermo Scientific Orbitrap Fusion LUMOS for rapid and comprehensive metabolomic profiling and detailed structural characterization, located at La Trobe University, and (ii) a Thermo Scientific Orbitrap Q Exactive HFX for high-throughput, deep and reproducible quantitative proteome analysis, located at the University of Melbourne.This platform will address applications across the agri-biosciences, medicinal agriculture and fundamental biomedical sciences sectors.Read moreRead less
Special Research Initiatives - Grant ID: SR120300015
Funder
Australian Research Council
Funding Amount
$16,000,000.00
Summary
The Science of Learning Research Centre. In this innovative new Centre, researchers in education, neuroscience and cognitive psychology will work together with teachers to understand the learning process. This collaboration will establish new criteria to assess the impact of different types of learning and strategies to inform teaching practices of benefit to all Australians.
Dating the aboriginal rock art sequence of the Kimberley in north west Australia. This project aims to develop a robust time scale for the known aboriginal rock art sequence in the Kimberley, Western Australia (WA). The project will use new knowledge of complex processes on sandstone surfaces across the north Kimberley, and an innovative combination of four scientific dating methods developed through our earlier work. The project expects to provide a well-dated sequence for Kimberley rock art ba ....Dating the aboriginal rock art sequence of the Kimberley in north west Australia. This project aims to develop a robust time scale for the known aboriginal rock art sequence in the Kimberley, Western Australia (WA). The project will use new knowledge of complex processes on sandstone surfaces across the north Kimberley, and an innovative combination of four scientific dating methods developed through our earlier work. The project expects to provide a well-dated sequence for Kimberley rock art based on replication of results, confirmation across different methods, and a large interdisciplinary data set. The project will allow rigorous analysis of the relationship between dating results and rock art styles that has not previously been possible, and give new insights into Australia’s deep indigenous heritage. This will have a significant impact for future efforts in rock art conservation, and lay a foundation for cultural tourism, with important benefits for the local economy and health of regional indigenous communities.Read moreRead less
Thermodynamics inversion for mineral systems. This project aims to provide a newly developed science approach to the Australian Lithospheric Architecture Magnetotelluric Project (AusLAMP). AusLAMP provides unparalleled geophysical information aimed at unravelling the tectonic history of the Australian continent and its mineral potential. The project will use thermodynamically based geodynamic simulators to jointly analyse and quantify intraplate deformation. This will illuminate the cause of dri ....Thermodynamics inversion for mineral systems. This project aims to provide a newly developed science approach to the Australian Lithospheric Architecture Magnetotelluric Project (AusLAMP). AusLAMP provides unparalleled geophysical information aimed at unravelling the tectonic history of the Australian continent and its mineral potential. The project will use thermodynamically based geodynamic simulators to jointly analyse and quantify intraplate deformation. This will illuminate the cause of driving fluid flow thorough the lithosphere, mineralisation phenomena, their datasets and geometries, and dynamic aspects of the processes driving mineral systems.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100015
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
An Ultra High Resolution Mass Spectrometry Facility for Lipidomics Research. An ultra-high-resolution mass spectrometry facility for lipidomics research:
This proposal aims to establish an ultra-high-resolution, accurate mass spectrometry facility in Australia for comprehensive lipidomics research. The platform would consist of a Thermo Scientific Orbitrap Fusion mass spectrometer interfaced with ultra-high-pressure high-performance liquid chromatography. This proposal will address a major need ....An Ultra High Resolution Mass Spectrometry Facility for Lipidomics Research. An ultra-high-resolution mass spectrometry facility for lipidomics research:
This proposal aims to establish an ultra-high-resolution, accurate mass spectrometry facility in Australia for comprehensive lipidomics research. The platform would consist of a Thermo Scientific Orbitrap Fusion mass spectrometer interfaced with ultra-high-pressure high-performance liquid chromatography. This proposal will address a major need for advanced mass spectrometry-based lipid analysis capabilities across mammalian, plant, parasite, and microalgae research disciplines, as well as enabling fundamental studies of lipid separation, chemistry and reactivity. The instrumentation would be applicable to a diverse range of projects including studies of the role of lipid metabolism in mammalian biochemistry and cell biology, plant biology and parasitology, and micro algae biofuel production.Read moreRead less
Next generation high throughput lipidomics using adaptive modelling. This project aims to develop a unique high-throughput method to capture the lipidomic profile of human plasma suitable for large human population screening. Lipids are fundamental to every biological system, but our understanding of their regulation in humans have been largely superficial. By incorporating a new lipidomics approach, with genomic data, this project aims to expand our understanding of human biology by identifying ....Next generation high throughput lipidomics using adaptive modelling. This project aims to develop a unique high-throughput method to capture the lipidomic profile of human plasma suitable for large human population screening. Lipids are fundamental to every biological system, but our understanding of their regulation in humans have been largely superficial. By incorporating a new lipidomics approach, with genomic data, this project aims to expand our understanding of human biology by identifying regulators of lipid metabolism. The large diversity in humans necessitate sufficient sample sizes to identify true genetic regulators, but to date techniques capturing phenotypic data (lipids) have been largely limited. It is anticipated that this study will identify new regulators of lipid metabolism in humans.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100159
Funder
Australian Research Council
Funding Amount
$160,000.00
Summary
Mobile Australian field isotope alliance. This project will enable a quantum leap in capacity to undertake, real-time, field-based studies of environmental processes using the natural isotope tracers of carbon, oxygen and hydrogen. This will enable the project to address a range of fundamental research questions in climate change, water resources, ecology and human impact in tropical Australia.
Tectonic geography of the world's oldest petroleum play, the McArthur Basin. This projects aims to develop a 4D tectonic geography framework to support the effective exploration of the McArthur Basin. This project will construct this by a) investigating the evolving tectonic setting, b) examining intra-basin correlations and trace the source to sink sediment provenance, c) unraveling the depositional geography using novel isotopic proxies, and, d) constructing the subsequent thermal history of ....Tectonic geography of the world's oldest petroleum play, the McArthur Basin. This projects aims to develop a 4D tectonic geography framework to support the effective exploration of the McArthur Basin. This project will construct this by a) investigating the evolving tectonic setting, b) examining intra-basin correlations and trace the source to sink sediment provenance, c) unraveling the depositional geography using novel isotopic proxies, and, d) constructing the subsequent thermal history of the basin. The techniques developed through this project will de-risk the exploration for petroleum in this basin, and be applicable in opening up Proterozoic petroleum elsewhere in Australia and internationally.Read moreRead less
What is 'natural'?: Locating and deciphering pre-human records of vegetation from northern Australian savannahs. The nature and magnitude of the environmental impact of human colonisation of Australia are fundamental issues in Australian prehistory and ecology. The project will locate and develop archives of environmental change from sinkholes in the Northern Territory that date back to the Last interglacial - a period which had a similar climate to the present day, but was before humans arrived ....What is 'natural'?: Locating and deciphering pre-human records of vegetation from northern Australian savannahs. The nature and magnitude of the environmental impact of human colonisation of Australia are fundamental issues in Australian prehistory and ecology. The project will locate and develop archives of environmental change from sinkholes in the Northern Territory that date back to the Last interglacial - a period which had a similar climate to the present day, but was before humans arrived.Read moreRead less