3D Histological And MRI Atlases Of Brain And Spinal Cord For Research And Clinical Practice
Funder
National Health and Medical Research Council
Funding Amount
$876,005.00
Summary
This project uses imaging techniques to produce the next generation of maps of the central nervous system. It will advance our understanding of the organisation and structure of the brain and spinal cord of humans and experimental animals, paving the way for the development of psychotherapeutic drugs and more accurate interventions on the human brain. The new maps will help those who study the brain of patients with diseases such as Alzheimer’s, Parkinson’s or animal models of these diseases.
Translation Of Genetic, Genomic And Transcriptomic Discoveries Into Clinical Practice
Funder
National Health and Medical Research Council
Funding Amount
$638,517.00
Summary
This project will progress studies on genes affecting common diseases to clinical application. Specifically, I aim to (1) establish the basis for the association of the identified MS risk factors with MS susceptibility; (2) establish if the three MS blood immune types we have identified, which are tagged by MS susceptibility genes, and altered by MS therapy, predict clinical response to therapy; and (3) determine the effect of host genetic variation in response to therapy for HCV, HIV and flu.
Imaging Atlases Of The Brain Of Humans And Experimental Animals
Funder
National Health and Medical Research Council
Funding Amount
$808,375.00
Summary
This project uses imaging techniques and molecular genetics to produce the next generation of brain maps. It will advance our understanding of the organisation and structure of the brain and spinal cord of humans and experimental animals – paving the way for the development of psychotherapeutic drugs and more accurate interventions on the human brain. The new maps will help those who study the brain of patients with diseases such as Alzheimer’s or Parkinson’s or animal models of these diseases.
Applying Next Generation Sequencing To Family Studies
Funder
National Health and Medical Research Council
Funding Amount
$182,622.00
Summary
Recent advances in technology can determine the DNA composition of a person for much longer stretches of DNA, at a much cheaper cost. I use statistical analysis to identify regions of the human genome that harbour mutations that cause diseases such as epilepsy in families. These regions contain 5-15 million base pairs. We need to find the ONE base pair that causes disease. This application deals with the development of new tools to exploit new technology for the identification of mutations.
Personalised Genomics In Precision Medicine Of Psychotic Illness
Funder
National Health and Medical Research Council
Funding Amount
$631,370.00
Summary
This research program will utilise recent developments in genomic technology to make detailed high-resolution genetic maps of individuals with psychotic illness. Where conventional gene discovery approaches focus on differences at the population level this program will integrate the variation within individuals to determine the network architecture. This will be used to generate genetic profiles for personalised medicine and provide the basis for treatments that are tailored to individuals.
Determining The Causes And Consequences Of Epigenetic Remodelling In Cancer And Disease
Funder
National Health and Medical Research Council
Funding Amount
$863,413.00
Summary
The study of epigenetics and its role in gene control is proving to be the next major contributor to our future understanding and improvement of health outcomes. Professor Clark and her team are on a quest to unravel the secrets of human epigenome to help reduce the burden of human disease. Their research will help contribute to the discovery of genetic and epigenetic aberrations in cancer and other complex diseases with the development of new diagnostic tests and potential new epigenetic-based ....The study of epigenetics and its role in gene control is proving to be the next major contributor to our future understanding and improvement of health outcomes. Professor Clark and her team are on a quest to unravel the secrets of human epigenome to help reduce the burden of human disease. Their research will help contribute to the discovery of genetic and epigenetic aberrations in cancer and other complex diseases with the development of new diagnostic tests and potential new epigenetic-based therapies.Read moreRead less
Developmental Neurobiology Of Schizophrenia And Translation Into New Treatments
Funder
National Health and Medical Research Council
Funding Amount
$611,574.00
Summary
Our ultimate goal is to expand effective treatment options for people with schizophrenia particularly ones that can prevent schizophrenia from developing. The successful completion of this project will identify novel biological pathways by which schizophrenia develops and, importantly, will yield new molecular tools to personalise treatment of schizophrenia.
I aim to decipher the role of heritable, genetic DNA variation in human neurological disease. I will use next generation genomics technologies together with sophisticated cellular models to address the important questions of the biology of epilepsy and intellectual disability in particular. I aim to develop a treatment for a specific type of epilepsy, which affects only girls from the age of 6 months. My ultimate goal is to improve the life of the patients and their relatives.
New genomic technologies are revolutionizing biological research. RNA-seq is a recently developed high-throughput sequencing technology that provides scientists with much more detail how genes are regulated and expressed than any earlier technology. New tools developed by Professor Gordon Smyth are allowing researchers to use RNA-Seq technology to more accurately determine which genes are genuinely changing in the development of cancers and in response to cancer treatments.