Understanding glycopolymer interactions with the extracellular matrix. This project aims to advance knowledge of the biochemical and biophysical structure of the endothelial glycocalyx, a dynamic cell surface extracellular matrix rich in proteoglycans and glycosaminoglycans. It will be the first to explore how charged glycopolymers interact with this dynamic interface with the goal to develop a model of the glycocalyx lifecycle. This project is expected to enable the transfer of skills, knowledg ....Understanding glycopolymer interactions with the extracellular matrix. This project aims to advance knowledge of the biochemical and biophysical structure of the endothelial glycocalyx, a dynamic cell surface extracellular matrix rich in proteoglycans and glycosaminoglycans. It will be the first to explore how charged glycopolymers interact with this dynamic interface with the goal to develop a model of the glycocalyx lifecycle. This project is expected to enable the transfer of skills, knowledge and ideas as well as advanced research and industrial training for young scientists. Knowledge derived from this project is expected to enable future innovation in molecules with tailored interactions with the glycocalyx with significant benefits for researchers, manufacturers and end users. Read moreRead less
Engineering nanomaterial interactions with the cell surface. This Fellowship aims to advance understanding of the endothelial cell surface, a key tissue barrier, and its interactions with nanomaterials. Enabled by cross-disciplinary collaboration, it expects to develop knowledge in matrix biology of the cell surface and materials as well as new methods to analyse their interactions. This is expected to unravel causal relationships between nanomaterial features and interactions at the cell surfac ....Engineering nanomaterial interactions with the cell surface. This Fellowship aims to advance understanding of the endothelial cell surface, a key tissue barrier, and its interactions with nanomaterials. Enabled by cross-disciplinary collaboration, it expects to develop knowledge in matrix biology of the cell surface and materials as well as new methods to analyse their interactions. This is expected to unravel causal relationships between nanomaterial features and interactions at the cell surface which will be integrated to engineer optimised materials. This will address the current and critical challenges of nanomaterial technologies in the efficient and targeted interactions with cells with long-term benefits for the consumer, biotechnology and healthcare sectors.Read moreRead less
Synergising pedodiversity and biodiversity to secure soil functionality. This project aims to understand the coupling between soil physical, chemical and biological diversity at a range of scales and land uses across New South Wales and its relationship with soil functioning. Soil diversity with its coupled biodiversity is crucial for conservation of sustainable ecosystems. Soil diversity varies on a continuum from microbial habitats to elds, catchments and regions. This project will enhance ou ....Synergising pedodiversity and biodiversity to secure soil functionality. This project aims to understand the coupling between soil physical, chemical and biological diversity at a range of scales and land uses across New South Wales and its relationship with soil functioning. Soil diversity with its coupled biodiversity is crucial for conservation of sustainable ecosystems. Soil diversity varies on a continuum from microbial habitats to elds, catchments and regions. This project will enhance our ability to understand the drivers of soil change through time, critical for minimising loss of biodiversity, achieving food and soil security and inferring effects of climate change.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL210100054
Funder
Australian Research Council
Funding Amount
$3,277,650.00
Summary
A calculable approach to securing Australia's soil. Much of our productive land is currently degraded, severely impacting the ability of soils to contribute to planetary health. The aim of this program is to deliver a comprehensive systematic soil monitoring system within a world-first soil security framework. The research will create a detailed reference of the Australian landscape to elucidate impacts on our soil cover. Soil security indicators will be created from which ameliorative actions c ....A calculable approach to securing Australia's soil. Much of our productive land is currently degraded, severely impacting the ability of soils to contribute to planetary health. The aim of this program is to deliver a comprehensive systematic soil monitoring system within a world-first soil security framework. The research will create a detailed reference of the Australian landscape to elucidate impacts on our soil cover. Soil security indicators will be created from which ameliorative actions can be prioritised, while early warning systems will offer predictive capability around emerging threats to soil condition, feeding into best-management practices for regeneration. Outcomes will see soil secured for future generations and Australia at the forefront of soil assessment and restoration.Read moreRead less
Forecasting soil conditions. Not knowing where and how soil responds to climate change and human intervention compromises food, water, climate and energy security. Currently there is a lack of soil process knowledge and data infrastructure collectively causing significant uncertainty and risk in the assessments of key threats to soil. The project devises a transformational digital soil model to forecast where and how soil pH and carbon will change in New South Wales. Tested on sites within Au ....Forecasting soil conditions. Not knowing where and how soil responds to climate change and human intervention compromises food, water, climate and energy security. Currently there is a lack of soil process knowledge and data infrastructure collectively causing significant uncertainty and risk in the assessments of key threats to soil. The project devises a transformational digital soil model to forecast where and how soil pH and carbon will change in New South Wales. Tested on sites within Australia, the model will give insight on the drivers of change and will provide a unique analysis of the effect of climate change and land management on the dynamics of soil.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210101144
Funder
Australian Research Council
Funding Amount
$429,450.00
Summary
Understanding crosstalks between Natural Killer cells and Dendritic Cells. This project aims to investigate the interactions between two populations of immune cells: natural killer cells and dendritic cells. This proposal will advance basic knowledge in immunology by innovating in considering the heterogeneity and diversity of these two immune populations and combining interdisciplinary approaches using cutting-edge technologies. Expected outcomes from this proposal include the identification of ....Understanding crosstalks between Natural Killer cells and Dendritic Cells. This project aims to investigate the interactions between two populations of immune cells: natural killer cells and dendritic cells. This proposal will advance basic knowledge in immunology by innovating in considering the heterogeneity and diversity of these two immune populations and combining interdisciplinary approaches using cutting-edge technologies. Expected outcomes from this proposal include the identification of new immunoregulatory pathways, the development of new scientific theories, and enhancement of Australia’s research capacity through international collaborations and student training. This project will provide significant benefits such as the identification of biological targets for development of new biotechnologies. Read moreRead less
The macrophage nucleus - its form and function during migration in vivo. As cells migrate through tissues, they encounter complex, 3-dimensional environments that provide cues to guide them and present obstacles in their path. This project focuses on macrophages, a large immune cell capable of both amoeboid and mesenchymal modes of migration. The nucleus is the largest organelle and its bulk and stiffness must be managed as migrating cells travel through constrictions. The project uses specialis ....The macrophage nucleus - its form and function during migration in vivo. As cells migrate through tissues, they encounter complex, 3-dimensional environments that provide cues to guide them and present obstacles in their path. This project focuses on macrophages, a large immune cell capable of both amoeboid and mesenchymal modes of migration. The nucleus is the largest organelle and its bulk and stiffness must be managed as migrating cells travel through constrictions. The project uses specialised high-end microscopy and genetic methods to examine how the nucleus of migrating zebrafish macrophages deforms, repositions and is restructured during migration in living tissues, and how this influences macrophage locomotion. The goal is to provide fundamental insights into the cell biology of macrophage migration.Read moreRead less
Microtubule structure in nervous system repair. This Project aims to investigate the role of structural and functional cellular components known as microtubules in nervous system regeneration. This Project aims to use innovative approaches in confocal and electron microscopy, genetics, and cell biology, with the expectation of generating new knowledge into nervous system repair. Expected outcomes of this Project include a comprehensive description of how microtubules are rearranged following ner ....Microtubule structure in nervous system repair. This Project aims to investigate the role of structural and functional cellular components known as microtubules in nervous system regeneration. This Project aims to use innovative approaches in confocal and electron microscopy, genetics, and cell biology, with the expectation of generating new knowledge into nervous system repair. Expected outcomes of this Project include a comprehensive description of how microtubules are rearranged following nervous system injury and the importance of microtubule modifying proteins in promoting regeneration. This should provide significant benefits in our understanding of the cellular mechanisms behind nervous system repair, and offer new approaches for promoting regeneration after injury.Read moreRead less