GABA(B) Receptor Modulation Of Gastrointestinal Function In Health And Disease By Alpha-Conotoxins
Funder
National Health and Medical Research Council
Funding Amount
$689,050.00
Summary
Chronic visceral pain is a common and debilitating condition arising from numerous diseases that affect our internal organs. There is a desperate need for more information about the mechanisms responsible for signalling chronic visceral pain to provide therapies and potentially find a cure for it. Our research focuses on ?-conotoxins (small peptides from marine cone snail venom) as novel potential therapeutic agents for the treatment of chronic visceral pain.
Using lasers to prime the immune system. This project aims to detail the precise effects that lasers have on eye cells, cell populations and the body as a whole. Laser treatments for sight problems are increasing but the effects of these laser applications on the unique immune systems of the eye and brain are unknown. Previous work of the researchers has shown that a novel nanosecond laser when targeted to the eye can alter cells in the lasered eye and in the unlasered eye and the brain. This kn ....Using lasers to prime the immune system. This project aims to detail the precise effects that lasers have on eye cells, cell populations and the body as a whole. Laser treatments for sight problems are increasing but the effects of these laser applications on the unique immune systems of the eye and brain are unknown. Previous work of the researchers has shown that a novel nanosecond laser when targeted to the eye can alter cells in the lasered eye and in the unlasered eye and the brain. This knowledge may be crucial for enhancing our understanding of the immune privileged state of the eye. In addition, it seeks to guide the development of future low energy lasers as important successful treatments.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561229
Funder
Australian Research Council
Funding Amount
$518,427.00
Summary
Establishment of a Multiphoton Microscope Imaging Platform for Live Cell and Tissue, and Optical Imaging. This proposal seeks to establish a multidisciplinary multiphoton imaging laboratory, expanding the imaging capabilities of a Core Regional Imaging Facility. This Facility supports researchers across all Monash campuses and hospital-based research Schools, as well as outside research groups in the Victorian region. Furthermore, this equipment will support significant fiber optic research at V ....Establishment of a Multiphoton Microscope Imaging Platform for Live Cell and Tissue, and Optical Imaging. This proposal seeks to establish a multidisciplinary multiphoton imaging laboratory, expanding the imaging capabilities of a Core Regional Imaging Facility. This Facility supports researchers across all Monash campuses and hospital-based research Schools, as well as outside research groups in the Victorian region. Furthermore, this equipment will support significant fiber optic research at Victoria University for the development of communication and endoscopic technology. The instrument design will allow multiple use of the lightsource and choice of specific imaging devices (microscopes) to ensure that applications in biocellular imaging, intravital microscopy and fiber optic design and imaging are individually optimised.Read moreRead less
Investigation of the fundamental roles of class Ib MHC (major histocompatibility complex) molecules in immunity. The proposed research program, using laboratory-based and synchrotron-based radiation, will provide insight into the roles of a poorly understood class of immune molecules. This will improve our understanding of the regulation of immunity, and the knowledge gained will increase Australia's international research profile.
Transcription factor nuclear residency as a driver of gene expression. Persistently active proteins can stay in the nucleus to drive cell growth and prevent cell death. This project will define how one specific active protein can remain in the nucleus and regulate gene expression through the action of unique ribonucleic acid (RNA) molecules. The results will enable persistent gene activation to be manipulated in cancer.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100202
Funder
Australian Research Council
Funding Amount
$255,120.00
Summary
Three-dimensional cryo correlative light and electron microscopy facility. This project aims to establish a three-dimensional (3D) cryo-correlative light and electron microscopy facility. The facility will integrate light microscopy with high resolution cryo-electron tomography and 3D slice-and-view focused ion beam scanning electron microscopy. The open access facility should create new capabilities for Australian researchers to tag biological events and structures with fluorescence markers and ....Three-dimensional cryo correlative light and electron microscopy facility. This project aims to establish a three-dimensional (3D) cryo-correlative light and electron microscopy facility. The facility will integrate light microscopy with high resolution cryo-electron tomography and 3D slice-and-view focused ion beam scanning electron microscopy. The open access facility should create new capabilities for Australian researchers to tag biological events and structures with fluorescence markers and image them using the currently highest resolution 3D imaging techniques for biological matter. The facility expects to reveal fundamental insights into cell and structural biology, and help drive innovation in agriculture, pharmaceutics, and biomaterials.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100011
Funder
Australian Research Council
Funding Amount
$346,439.00
Summary
Spinning disk confocal microscope with dual stages. Spinning disk confocal microscope with dual stages: This custom-built spinning disk confocal microscope with rotational stages will constitute an internationally unique platform. The system has the capability of rapidly monitoring cells in growing biological specimens under changing environments. It offers an integrated platform for multiple imaging strategies, including confocal and Total Internal Reflection Fluorescence (TIRF) microscopy. The ....Spinning disk confocal microscope with dual stages. Spinning disk confocal microscope with dual stages: This custom-built spinning disk confocal microscope with rotational stages will constitute an internationally unique platform. The system has the capability of rapidly monitoring cells in growing biological specimens under changing environments. It offers an integrated platform for multiple imaging strategies, including confocal and Total Internal Reflection Fluorescence (TIRF) microscopy. The system will reside in core facilities with open access to a broad research community. The system may be used to monitor a wide variety of cells and molecules, and will offer capabilities that are of importance to understand cell trafficking, disease and signalling, plant biomass production, and climate change.Read moreRead less