Group 13 Mixed Halide-Hydride and Rare Earth Complexes - New Selective Chiral Hydridic or Low Valent Reducing Agents. This project will make a landmark contribution to two areas of metallohydride chemistry. Both studies will utilise and develop metals that have traditionally been mined and exported from these shores while concurrently imported as value added products at vastly inflated cost. This research will identify knock-on applications in order to stem this financial bias. The new paths to ....Group 13 Mixed Halide-Hydride and Rare Earth Complexes - New Selective Chiral Hydridic or Low Valent Reducing Agents. This project will make a landmark contribution to two areas of metallohydride chemistry. Both studies will utilise and develop metals that have traditionally been mined and exported from these shores while concurrently imported as value added products at vastly inflated cost. This research will identify knock-on applications in order to stem this financial bias. The new paths to rare earth (= Ln) hydrides will have broad industrial appeal, particularly for new materials, where, like similar group 13 materials, they may be used in the deposition of Ln films or even as precursors to superconducting solids. It is anticipated industrial collaboration will ensue. Australia will be promoted as a developer and innovator of frontier technologies.Read moreRead less
Enhancing single-molecule magnets. This project aims to design, synthesise and investigate single-molecule magnets that can function at higher temperatures for use in quantum computing and molecular spintronics. Materials science increasingly benefit from molecular approaches, and lanthanoid-based single-molecule magnets could achieve otherwise inaccessible technological developments such as the development of molecular materials for quantum computing and molecular spintronics. Advances in funda ....Enhancing single-molecule magnets. This project aims to design, synthesise and investigate single-molecule magnets that can function at higher temperatures for use in quantum computing and molecular spintronics. Materials science increasingly benefit from molecular approaches, and lanthanoid-based single-molecule magnets could achieve otherwise inaccessible technological developments such as the development of molecular materials for quantum computing and molecular spintronics. Advances in fundamental chemistry are anticipated, and this project is expected to benefit Australia's participation in related high-end technology industries.Read moreRead less
Charge-Controlled Materials for Separations of Important Resources. This project aims to develop new porous materials that are capable of greater molecular discrimination than current technologies. This project expects to advance understanding of fundamental structure-activity relationships in these materials, and synthetic targets will be geared towards materials for industrially or environmentally important chemical separations associated with metal extraction. Expected outcomes of this projec ....Charge-Controlled Materials for Separations of Important Resources. This project aims to develop new porous materials that are capable of greater molecular discrimination than current technologies. This project expects to advance understanding of fundamental structure-activity relationships in these materials, and synthetic targets will be geared towards materials for industrially or environmentally important chemical separations associated with metal extraction. Expected outcomes of this project include new insights on the underlying chemistry for tailoring crystalline microporous materials towards select applications. This should provide significant benefits, such as future low-energy and efficient technologies for industrially important separation processes with reduced financial and environmental costs.Read moreRead less
Expanding the molecular tool set for structural studies of proteins and their complexes. Many applications in medical science and drug development depend on our ability to determine the 3D structures of proteins, protein assemblies and protein-ligand complexes. This project will develop novel lanthanide-binding tags and crosslinking agents that can be coupled to unnatural amino acids introduced into proteins with advanced protein chemistry techniques. These new tools will facilitate the collecti ....Expanding the molecular tool set for structural studies of proteins and their complexes. Many applications in medical science and drug development depend on our ability to determine the 3D structures of proteins, protein assemblies and protein-ligand complexes. This project will develop novel lanthanide-binding tags and crosslinking agents that can be coupled to unnatural amino acids introduced into proteins with advanced protein chemistry techniques. These new tools will facilitate the collection of structure restraints by nuclear magnetic resonance (NMR), electron paramagnetic resonance (EPR) and mass spectrometry, which are needed to generate accurate models of proteins and their complexes with other molecules. Major beneficial outcome will include an increase in the number of protein targets amenable to rational drug design and improved methods for generating new drug leads.Read moreRead less
Development and Biological Chemistry of Novel Platinum Anti-Cancer Agents. "Rule-breakers", platinum anticancer complexes that do not follow the well established structure/activity relationships, have emerged as the way forward in the treatment of cancer resistant to the current generation of drugs and in reducing side effects. We have developed two new groups of "rule-breakers" and these have already demonstrated highly promising anticancer activity and novel biological behaviour. In this proje ....Development and Biological Chemistry of Novel Platinum Anti-Cancer Agents. "Rule-breakers", platinum anticancer complexes that do not follow the well established structure/activity relationships, have emerged as the way forward in the treatment of cancer resistant to the current generation of drugs and in reducing side effects. We have developed two new groups of "rule-breakers" and these have already demonstrated highly promising anticancer activity and novel biological behaviour. In this project we will (i) prepare new anticancer active platinum complexes based on these two highly promising groups of compounds and (ii) determine how these drugs work and what happens to them when in biological environments.Read moreRead less
Thin Films of Oxide Ceramics. Aluminium oxide films are used extensively in the Australian industries of Protective & Decorative Coatings (examples include door-knobs and cutting-tools). The industry will be offered a remarkably simple process for preparation of high quality films. In the microelectronic industry, the uses of aluminium oxide films as a dielectric alternative to silicon dioxide has just started to emerge world - wide and this new process would make a dramatic impact with commerci ....Thin Films of Oxide Ceramics. Aluminium oxide films are used extensively in the Australian industries of Protective & Decorative Coatings (examples include door-knobs and cutting-tools). The industry will be offered a remarkably simple process for preparation of high quality films. In the microelectronic industry, the uses of aluminium oxide films as a dielectric alternative to silicon dioxide has just started to emerge world - wide and this new process would make a dramatic impact with commercial benefits for Australia. Read moreRead less
Reactivity and Spectroscopy of Gas Phase Metal Oxide Cluster Ions: Structure-Reactivity Correlations and Fundamental Insights into Heterogeneous Catalysis. This project will make use of world class ARC funded instrumentation to carry out breakthrough science. The research will contribute fundamental insights into chemical bond activation relevant to industrial catalytic processes important to national manufacturing industries. These insights will improve the efficiency and selectivity of catal ....Reactivity and Spectroscopy of Gas Phase Metal Oxide Cluster Ions: Structure-Reactivity Correlations and Fundamental Insights into Heterogeneous Catalysis. This project will make use of world class ARC funded instrumentation to carry out breakthrough science. The research will contribute fundamental insights into chemical bond activation relevant to industrial catalytic processes important to national manufacturing industries. These insights will improve the efficiency and selectivity of catalytic processes and lead to increased profitability and/or a reduction in unwanted side products and pollution. The project will train young scientists in important experimental and theoretical chemical techniques, and will enhance and contribute to Australia's international research profile.Read moreRead less
Microprobe and Nanoprobe Studies on Intracellular Disease Processes and Their Treatment. Breakthrough microprobe and nanoprobe technologies, involving X-ray, visible and infrared light can focus into different components of mammalian cells in order to interrogate the biochemistry that is occurring therein. Each of the different wavelengths of light provides complementary biochemical information that enables a deeper understanding of changes in cells that occur as a function of drug treatments an ....Microprobe and Nanoprobe Studies on Intracellular Disease Processes and Their Treatment. Breakthrough microprobe and nanoprobe technologies, involving X-ray, visible and infrared light can focus into different components of mammalian cells in order to interrogate the biochemistry that is occurring therein. Each of the different wavelengths of light provides complementary biochemical information that enables a deeper understanding of changes in cells that occur as a function of drug treatments and disease processes. This will provide unprecedented information as to where drugs go and how they are transformed inside cells that, in turn, may revolutionalise the way in which new drugs are designed that have higher specificity and fewer side effects.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0221983
Funder
Australian Research Council
Funding Amount
$900,000.00
Summary
Interface, Particle and Complex Fluid Characterisation Laboratory. This laboratory will provide a state-of-the-art characterisation facility for complex fluids. This will service the needs of 27 research staff and 38 postgraduate students and involve collaboration between twelve major research groups based at the Universities of Melbourne, Newcastle, Monash, La Trobe and RMIT. The facility will enhance the research activities of the collaborating institutions in key strategic areas. The laborat ....Interface, Particle and Complex Fluid Characterisation Laboratory. This laboratory will provide a state-of-the-art characterisation facility for complex fluids. This will service the needs of 27 research staff and 38 postgraduate students and involve collaboration between twelve major research groups based at the Universities of Melbourne, Newcastle, Monash, La Trobe and RMIT. The facility will enhance the research activities of the collaborating institutions in key strategic areas. The laboratory will also act as a facility for undertaking consulting projects with industry groups by the applicants.Read moreRead less