Cell–fluid interaction: inside and outside cells. The project aims to measure mechanics at the cellular level using a combination of optical tweezers for measurement of nano-scale environment around/inside cells and light-sheet microscopy for imaging. The project expects to generate new knowledge about movement of cells through their environment, relating to collective behaviour which is of importance in understanding infections and formation of biofilms. Expected outcomes include deepened under ....Cell–fluid interaction: inside and outside cells. The project aims to measure mechanics at the cellular level using a combination of optical tweezers for measurement of nano-scale environment around/inside cells and light-sheet microscopy for imaging. The project expects to generate new knowledge about movement of cells through their environment, relating to collective behaviour which is of importance in understanding infections and formation of biofilms. Expected outcomes include deepened understanding of an enigmatic process conserved from amoebae to humans, by which cells ‘drink and eat’ by ‘gulping’ fluid and supplement their nutrient intake by degrading proteins and cell debris. It will generate new knowledge of these processes to better understand how mechanics affects cellular life.Read moreRead less
Analysis of asteroid samples returned by Hayabusa 2 and Osiris-REx . This year sees the highly anticipated return of the Hayabusa2 spacecraft to Woomera carrying samples of the asteroid Ryugu. This is only the fifth extraterrestrial sample return mission in history. The research team has been invited to participate in the preliminary examination which will take place in Japan in early 2021. The investigators have developed unique analytical skills that allow measurement of small amounts of rock ....Analysis of asteroid samples returned by Hayabusa 2 and Osiris-REx . This year sees the highly anticipated return of the Hayabusa2 spacecraft to Woomera carrying samples of the asteroid Ryugu. This is only the fifth extraterrestrial sample return mission in history. The research team has been invited to participate in the preliminary examination which will take place in Japan in early 2021. The investigators have developed unique analytical skills that allow measurement of small amounts of rock for oxygen isotope compositions at unprecedented precision. This project aims to characterise a suite of carbonaceous chondrites, which appear to be the best match to Ryugu, and therefore will provide the exemplar data to understand the provenance of Ryugu, and place it in the context of solar system materials.
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Laser-free on-chip super-resolution microscopy. The project aims to develop a compact, cost-effective on-chip super-resolution microscope through an innovative combination of imaging algorithms, optics and integrated photonics. This project addresses limitations in imaging algorithms that increase laser system complexity and constrain imaging speed and applications, as well as nanostructure fabrication issues. Expected outcomes include the discovery of emitter self-interference microscopy, new k ....Laser-free on-chip super-resolution microscopy. The project aims to develop a compact, cost-effective on-chip super-resolution microscope through an innovative combination of imaging algorithms, optics and integrated photonics. This project addresses limitations in imaging algorithms that increase laser system complexity and constrain imaging speed and applications, as well as nanostructure fabrication issues. Expected outcomes include the discovery of emitter self-interference microscopy, new knowledge in imaging, photonics and biophysics, the world’s fastest super-resolution technology, compact on-chip nanoscopy that can be added to existing technology and proof of concept in three areas. Benefits are anticipated in commercialisation, improved photonics devices and usage in biophysics.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100079
Funder
Australian Research Council
Funding Amount
$411,918.00
Summary
Anisotropic single-particle transducers. The project aims to tackle a major challenge in techniques that manipulate tiny particles – increasing the performance of transducer devices that convert magnetic forces to mechanical movement. It will centre on interactions on the surface of particular particles, bypassing a known scientific limit. Expected outcomes include a fundamental understanding of key factors that have recently been shown to enhance magnetic responsivity and efficient mechanical m ....Anisotropic single-particle transducers. The project aims to tackle a major challenge in techniques that manipulate tiny particles – increasing the performance of transducer devices that convert magnetic forces to mechanical movement. It will centre on interactions on the surface of particular particles, bypassing a known scientific limit. Expected outcomes include a fundamental understanding of key factors that have recently been shown to enhance magnetic responsivity and efficient mechanical manipulation and sensing in a magnetic field. The project outcomes will benefit developers by, for example, advanced nanoscale devices for robotics, sensing and molecular bioassays; controlling biophysical processes; and fundamental mechanobiology research.Read moreRead less
Replicating the cartilage micromechanical environment. Through a novel, image-guided mechanical evaluation of cell- and tissue-level remodelling, this project aims to unlock new insights into the complex mechanical microenvironment of cartilage and directly influence new strategies in tissue engineering. The research will reveal contributions of cells and extracellular matrix components to mechanical integrity over time. It will build a world-first strain map of the cartilage microenvironment an ....Replicating the cartilage micromechanical environment. Through a novel, image-guided mechanical evaluation of cell- and tissue-level remodelling, this project aims to unlock new insights into the complex mechanical microenvironment of cartilage and directly influence new strategies in tissue engineering. The research will reveal contributions of cells and extracellular matrix components to mechanical integrity over time. It will build a world-first strain map of the cartilage microenvironment and quantification of dynamic structural remodelling that occurs, providing key targets to improve tissue engineering strategies. The project will also drive innovation in micromechanical testing technology, deliver functional solutions in mechanobiology and advance materials for biological integration.Read moreRead less
ARC Centre of Excellence in Quantum Biotechnology. ARC Centre of Excellence in Quantum Biotechnology. The ARC Centre of Excellence in Quantum Biotechnology aims to develop paradigm-shifting quantum technologies to observe biological processes and transform our understanding of life. It seeks to create technologies that go far beyond what is possible today, from portable brain imagers to super-fast single protein sensors, and to use them to unravel key problems including how enzymes catalyse reac ....ARC Centre of Excellence in Quantum Biotechnology. ARC Centre of Excellence in Quantum Biotechnology. The ARC Centre of Excellence in Quantum Biotechnology aims to develop paradigm-shifting quantum technologies to observe biological processes and transform our understanding of life. It seeks to create technologies that go far beyond what is possible today, from portable brain imagers to super-fast single protein sensors, and to use them to unravel key problems including how enzymes catalyse reactions and how higher brain function emerges from networks of neurons. By building a diverse, multidisciplinary, and industry-engaged ecosystem, the Centre means to develop our future leaders at the interface of quantum science and biology and drive Australian innovation across manufacturing, energy, agriculture, health, and national security.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100934
Funder
Australian Research Council
Funding Amount
$439,082.00
Summary
Taming the light: full control in polarisation, space, and time. This project aims to develop two prototype optical beam shaping systems, culminating in the demonstration of new high-power optical fibre amplifiers. This novel ability to control all the properties of light enables the generation of optical beams that were only theoretical ideas but never previously implemented experimentally. This advanced technology can potentially open new ways in which objects can be probed using light. Expect ....Taming the light: full control in polarisation, space, and time. This project aims to develop two prototype optical beam shaping systems, culminating in the demonstration of new high-power optical fibre amplifiers. This novel ability to control all the properties of light enables the generation of optical beams that were only theoretical ideas but never previously implemented experimentally. This advanced technology can potentially open new ways in which objects can be probed using light. Expected outcomes include the creation of an optical platform that the optical community at large may utilise for their specific applications. Besides the intellectual property benefits of such optical devices directly, this project should bridge the gap between the developed knowledge and commercial opportunities.Read moreRead less
Integrin Activation by Fluid Flow Disturbance: Mechanobiology Approaches. Understanding how cells can sense and respond to mechanical environment such as dynamic blood flow represents a fundamental question in the emerging field of mechanobiology. This project develops new biomechanical engineering approaches to determine the critical interrelationships among fluid flow disturbance, platelet clotting and the mechano-sensitive signal transduction mechanisms of integrin receptor – the most importa ....Integrin Activation by Fluid Flow Disturbance: Mechanobiology Approaches. Understanding how cells can sense and respond to mechanical environment such as dynamic blood flow represents a fundamental question in the emerging field of mechanobiology. This project develops new biomechanical engineering approaches to determine the critical interrelationships among fluid flow disturbance, platelet clotting and the mechano-sensitive signal transduction mechanisms of integrin receptor – the most important mechano-sensor implicated in cell adhesion, migration, growth and survival. Specifically, it integrates nationally unique cutting-edge techniques including single-molecule force probe, microparticle image velocimetry, microfluidics and molecular dynamics simulation, super resolution and 3D volumetric imaging modalities.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100487
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
Thermal hotspots detection in nanoscale two-dimensional electronics. The emergence of flexible nanoelectronics holds the promise to impact the way we live—from smart wearables to foldable smartphones. However, heat dissipation in the atomically-thin materials used for their conception has remained poorly understood due to their planar structures. This project aims at the detection and mapping of nanoscale thermal hotspots in flexible nanoelectronics devices using a two-dimensional-based optical ....Thermal hotspots detection in nanoscale two-dimensional electronics. The emergence of flexible nanoelectronics holds the promise to impact the way we live—from smart wearables to foldable smartphones. However, heat dissipation in the atomically-thin materials used for their conception has remained poorly understood due to their planar structures. This project aims at the detection and mapping of nanoscale thermal hotspots in flexible nanoelectronics devices using a two-dimensional-based optical thermometer. The expected outcome of this project is the development of a non-invasive thermometric technology that enables locating these critical nanoscale hotspots with nanoscale precision. This will lead to better design and manufacturing strategies for heat dissipation in these devices.Read moreRead less
High shear fluid flow driving carbon foundry for advanced manufacturing. This project aims to develop versatile continuous flow thin film microfluidic device technology for harnessing contact electrification generated by sub-micron high shear flows in fabricating novel and high-performance nano-carbons for which current methods are ineffective or impossible. This project expects to generate new knowledge on complex vortex fluid fields, their intricate interactions with external electric and magn ....High shear fluid flow driving carbon foundry for advanced manufacturing. This project aims to develop versatile continuous flow thin film microfluidic device technology for harnessing contact electrification generated by sub-micron high shear flows in fabricating novel and high-performance nano-carbons for which current methods are ineffective or impossible. This project expects to generate new knowledge on complex vortex fluid fields, their intricate interactions with external electric and magnetic fields and carbon nanostructure formation. Expected outcomes for this project include exquisite control on reforming nanocarbon with tuneable properties and unprecedented hetero-structures. This should provide significant benefits, such as in generating new processes and products for advanced manufacturing. Read moreRead less