Understanding And Preventing Physical And Cognitive Decline And Falls In Older People With Dementia
Funder
National Health and Medical Research Council
Funding Amount
$509,626.00
Summary
Falls are common in people with dementia and are more likely to result in injury, death and institutionalisation. There is limited evidence that falls can be prevented in this group. Strategies aimed at maintaining independence and preventing decline and falls are urgently needed. This research will a) further our understanding of fall risk and functional decline and b) explore novel fall and decline prevention programs, including the use of technology in older people with dementia.
IStoppFalls: ICT Based System To Predict & Prevent Falls
Funder
National Health and Medical Research Council
Funding Amount
$579,018.00
Summary
Technology-based solutions have potential to increase effectiveness of individualized quality healthcare while reducing costs and using scarce human resources to maximum effect. Fall prediction and prevention is a research field where technology can be used to facilitate healthy ageing, well-being and independent living. The primary aim of the iStoppFalls project is to develop and evaluate innovative home-based technologies for continuous monitoring and prevention of falls risk in older adults.
The my-AHA project will develop and trial ICT based interventions for aging related frailty. These in-home ICT interventions are designed to reduce the incidence of conditions of frailty and resulting disability on older adults through the use of physical, cognitive, psychological, and social interventions. The project is a international collaboration of 16 organisations from Australia, Asia, and Europe.
BRIDGET: BRain Imaging, Cognition, Dementia And Next Generation GEnomics: A Transdisciplinary Approach To Search For Risk And Protective Factors Of Neurodegenerative Disease
Funder
National Health and Medical Research Council
Funding Amount
$1,081,489.00
Summary
Alzheimer’s disease (AD) begins many years before diagnosis and yet its aetiology is still poorly understood. The BRIDGET consortium aims to identify genetic variants that are associated with structural brain ageing, cognitive performance, and dementia risk in richly phenotyped international and Australian population-based samples. This work aims to provide crucial information on the molecular pathways leading to AD, potentially leading to improved health outcomes for our ageing population.
Comprehensive Risk Prediction Models And Presymptomatic Biomarkers For Dementia.
Funder
National Health and Medical Research Council
Funding Amount
$720,144.00
Summary
Extensive information on a large population of over 15,000 older Australians will be used to determine more precisely which factors increase or reduce the risk of developing dementia, and thus will provide valuable information on how to reduce the number of Australians with dementia. In parallel, this research will identify new ways to accurately diagnose dementia at an earlier stage, even before symptoms appear.
Improving Mental Health And Social Participation Outcomes In Older Adults With Depression And Anxiety
Funder
National Health and Medical Research Council
Funding Amount
$791,581.00
Summary
This study will evaluate a comprehensive treatment program for older adults who are suffering depression and anxiety. We expect that this new treatment program will be more powerful than standard cognitive behavioural therapy. Through this treatment we will increase social participation and quality of life and reduce depression and anxiety in older Australians.
Identifying Novel Lipid And Genetic Signatures Of Metabolic Disease In Early Childhood
Funder
National Health and Medical Research Council
Funding Amount
$354,592.00
Summary
Both our genetic makeup and environment can contribute to the development of obesity, diabetes and heart disease. Although onset usually occurs in adulthood, the progression towards disease can start in early life. Early childhood represents an opportunity for intervention to avoid adverse health outcomes in adulthood. This proposal combines two established birth cohorts from Singapore (GUSTO) and Australia (BIS) to examine the genetic and environmental origins of metabolic diseases.
Sleep-wake Disturbances And Cardio-metabolic Dysfunction In At Risk Dementia: A Novel Pathway In Neurocognitive Decline’
Funder
National Health and Medical Research Council
Funding Amount
$558,305.00
Summary
Age-related sleep and circadian disturbance and cardio-metabolic dysfunction are associated with an increased risk of dementia. This research aims to delineate the pathway in which sleep and circadian disturbances and cardio-metabolic dysfunction promote cognitive decline during the ‘at risk’ dementia phase. This will improve our understanding of key processes in cognitive ageing ultimately leading to the development of targeted intervention programs in the quest to delay the onset of dementia.
Novel Assessment And Intervention For Dementia: An Inter-disciplinary Translational Approach
Funder
National Health and Medical Research Council
Funding Amount
$720,021.00
Summary
This program of research focuses on i) a highly novel internationally competitive program of work focusing on the neural network correlates of sleep in dementia, sleep as a risk factor and the efficacy of sleep-wake interventions in reducing cognitive decline; ii) Innovative technologies for widespread screening of preclinical dementia and early intervention and iii) clinical trials focused on the testing of a of novel, highly translatable dementia risk reduction interventions.
Genetic Biomarkers And Molecular Pathways For Migraine
Funder
National Health and Medical Research Council
Funding Amount
$273,988.00
Summary
Common migraine, is a frequent, debilitating and painful disorder that affects people during their most productive years (up to 25% of women and 8% of men). Our recent results indicate the presence of multiple genetic factors contributing towards migraine susceptibility. Utilising detailed migraine symptom and medication data, larger numbers of migraine cases and controls, and applying the latest genotyping and imputation technologies, we will identify novel genetic biomarkers and molecular path ....Common migraine, is a frequent, debilitating and painful disorder that affects people during their most productive years (up to 25% of women and 8% of men). Our recent results indicate the presence of multiple genetic factors contributing towards migraine susceptibility. Utilising detailed migraine symptom and medication data, larger numbers of migraine cases and controls, and applying the latest genotyping and imputation technologies, we will identify novel genetic biomarkers and molecular pathways for migraine.Read moreRead less