Enhancing mothers' engagement with the workforce in the preschool years. Increasing the workforce participation of mothers is a key national policy agenda. This project will produce unique data that provides insights into how leave arrangements, childcare, flexibility, job characteristics and individual circumstances interact to influence mothers' workforce engagement and how this varies for different groups of mothers.
Living apart together: how mobile work is transforming Australian homes. This project aims to provide important information about how mobile work is transforming Australian homes. Mobile working practices – where the labour force is away from their homes for days, or even weeks, at a time – are an increasingly essential but under-explored part of Australia’s economy. However, the social impacts on personal and family wellbeing are not well understood. This project aims to investigate the changes ....Living apart together: how mobile work is transforming Australian homes. This project aims to provide important information about how mobile work is transforming Australian homes. Mobile working practices – where the labour force is away from their homes for days, or even weeks, at a time – are an increasingly essential but under-explored part of Australia’s economy. However, the social impacts on personal and family wellbeing are not well understood. This project aims to investigate the changes wrought by different sorts of mobile work on household life in Australia, with specific attention to personal and family wellbeing. It also plans to undertake qualitative research with stakeholders and households to identify the kinds of multifaceted support that might be required for this practice to flourish without negative impacts.Read moreRead less
Are the kids alright? Understanding the wellbeing of Australian children in their middle years. This project will produce the first comprehensive national stock-take of wellbeing among Australian children in their middle years, with a special focus on children who experience disadvantage. Findings will reflect children's views and experiences, have direct policy relevance and lay the groundwork for comparing and monitoring of child wellbeing.
Trends in Time: Work, Family and Social Policy in Australia 1992-2006. This project will contribute to the national priority goal of 'strengthening Australia's social and economic fabric to help families and individuals live healthy, productive, and fulfilling lives', within the National Research Priority of 'promoting good health and well being for all Australians'. It will provide sound new evidence for effective strategies fostering the policy goals of reducing stress on families, maintaining ....Trends in Time: Work, Family and Social Policy in Australia 1992-2006. This project will contribute to the national priority goal of 'strengthening Australia's social and economic fabric to help families and individuals live healthy, productive, and fulfilling lives', within the National Research Priority of 'promoting good health and well being for all Australians'. It will provide sound new evidence for effective strategies fostering the policy goals of reducing stress on families, maintaining fertility and encouraging women into paid work. Identifying measures that most support men and women to balance work-family commitments, to spend adequate time with their children and social networks, and most facilitate female workforce participation, will promote national wellbeing. Read moreRead less
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Alpha-particles linked to recombinant antibodies targeting tumour cells have potential to effectively treat tumours while minimising normal tissue side effects. We will explore a novel alpha-particle therapy approach to solid tumours, by delivering 225Ac directly into tumour cells, or into cells that support the tumour (microenvironment). This approach will hopefully result in development of a new approach to treatment of cancers that are resistant to conventional therapies.
Melanotransferrin: A “Missing Link” And A Novel Pharmacological Target For Treatment
Funder
National Health and Medical Research Council
Funding Amount
$613,848.00
Summary
Despite >30 years of research, the precise function of the protein, melanotransferrin (MTf), is unknown. However, we have breakthrough evidence that MTf stimulates WNT signalling as a major driver in cancer progression. We will investigate this hypothesis, which will underpin new cancer therapies. Indeed, we designed a new class of drugs that target the WNT pathway via up-regulating the WNT inhibitor, NDRG1. This drug (DpC) inhibits MTf expression to block tumour cell growth and metastasis.
Carers and social inclusion: new frameworks, evidence and policy lessons. This project aims to improve our understanding of informal carers' social inclusion through new conceptual frameworks, geographical and longitudinal analysis and lessons from international best practice. The outcomes of the project will inform Australia policies fostering social inclusion and the social and economic wellbeing of Australian carers.
Enhancing Reproductive Opportunity in Australia: Reconsidering Consent, Altruism and the Legal Status of Embryos in ART Processes. This project meets the national research priority of a healthy start to life by enhancing reproductive opportunity while safeguarding the rights and interests of all involved in reproduction with donor gametes. This research will create significant national benefits in the form of an up to date, practical and coherent platform for the reform of all aspects of embryo ....Enhancing Reproductive Opportunity in Australia: Reconsidering Consent, Altruism and the Legal Status of Embryos in ART Processes. This project meets the national research priority of a healthy start to life by enhancing reproductive opportunity while safeguarding the rights and interests of all involved in reproduction with donor gametes. This research will create significant national benefits in the form of an up to date, practical and coherent platform for the reform of all aspects of embryo and gamete donation and embryo disputes. We propose a pro-active consultative model that centres the needs and experiences of gamete and embryo donors and recipients. Our research will inform current and future modes of regulation of gamete and embryo donation and dispute resolution, including legislation, ethics guidelines and codes of practice.Read moreRead less
ARC Centre of Excellence for Children and Families over the Life Course. New solutions are needed to underpin the Australian social ideal of a fair go, and to drive future global economic productivity. The Australian Productivity Commission identifies deep and persistent disadvantage as a significant problem in Australia given the failure of growing national prosperity over the past two decades to benefit underprivileged Australians. Social disadvantage is a global challenge. This Centre will ad ....ARC Centre of Excellence for Children and Families over the Life Course. New solutions are needed to underpin the Australian social ideal of a fair go, and to drive future global economic productivity. The Australian Productivity Commission identifies deep and persistent disadvantage as a significant problem in Australia given the failure of growing national prosperity over the past two decades to benefit underprivileged Australians. Social disadvantage is a global challenge. This Centre will advance basic, applied and translational research to reduce intergenerational and long-term disadvantage. Through the maturation of longitudinal datasets and advanced data integration we can follow the journeys of Australian families over generations and across the life course. This data will provide evidence for new policies and make a real difference to the lives of children and families.Read moreRead less