Preclinical Development Of A Therapeutic Anticancer Antibody To C-Met
Funder
National Health and Medical Research Council
Funding Amount
$435,530.00
Summary
Many common cancers cannot be effectively treated. A range of these cancers (e.g. gastric and lung cancer) display the molecule c-Met on their cell surface. c-Met promotes tumour growth; therefore, blocking c-Met is a promising strategy for treating these cancers. However, no antibodies or drugs that target c-Met have been licensed. The therapeutics that are being developed to target c-Met all have considerable limitations. Thus, there is an opportunity to develop a 'best-in-class' therapeutic.
Facilitating the attainment of difficult goals: From theory to intervention. Being persistent in pursuing an important goal is glorified in society. People, however, often need to be strategic in their goal pursuits. A series of lab and field studies will aim to test how helping individuals to realise early in their goal striving whether their goal is attainable or not, can support them in making the right decision (persist with, abandon, or change the goal). The project will make novel contribu ....Facilitating the attainment of difficult goals: From theory to intervention. Being persistent in pursuing an important goal is glorified in society. People, however, often need to be strategic in their goal pursuits. A series of lab and field studies will aim to test how helping individuals to realise early in their goal striving whether their goal is attainable or not, can support them in making the right decision (persist with, abandon, or change the goal). The project will make novel contributions to theories of motivation and goal regulation. It will also have significant public benefit as it will provide the necessary evidence for the development of brief interventions that maximise the efficient use of individuals’ limited resources, facilitating individual and societal productivity and well-being.Read moreRead less
ARC Centre of Excellence for Children and Families over the Life Course. The 2020 ARC Centre of Excellence for Children and Families over the Life Course (LCC2020) aims to deliver transformative research and translation to break the cycle of deep and persistent disadvantage for Australians. Critically, LCC2020 will tackle disadvantage in specific context to understand how people negotiate it daily in real places, and how best to design policies and programs that support improved life pathways. B ....ARC Centre of Excellence for Children and Families over the Life Course. The 2020 ARC Centre of Excellence for Children and Families over the Life Course (LCC2020) aims to deliver transformative research and translation to break the cycle of deep and persistent disadvantage for Australians. Critically, LCC2020 will tackle disadvantage in specific context to understand how people negotiate it daily in real places, and how best to design policies and programs that support improved life pathways. By understanding life course contexts much more finely and using new methods and better data to personalise responses to disadvantage, LCC2020 will deliver the evidence, infrastructure, capacity and partnerships to reduce disadvantage and better equip Australian children and families for emerging challenges. Read moreRead less
Are the kids alright? Understanding the wellbeing of Australian children in their middle years. This project will produce the first comprehensive national stock-take of wellbeing among Australian children in their middle years, with a special focus on children who experience disadvantage. Findings will reflect children's views and experiences, have direct policy relevance and lay the groundwork for comparing and monitoring of child wellbeing.
Enhancing outcomes for young people in out-of-home care who self-place. This project aims to enhance the safety and well-being of young people in out-of-home care who leave formal placements to stay in unapproved locations. The significance lies in the development of new knowledge with this group of young people about their needs and of factors shaping effective responses to them. Expected outcomes include the generation of policies and practices to reduce the drivers of young people leaving a ....Enhancing outcomes for young people in out-of-home care who self-place. This project aims to enhance the safety and well-being of young people in out-of-home care who leave formal placements to stay in unapproved locations. The significance lies in the development of new knowledge with this group of young people about their needs and of factors shaping effective responses to them. Expected outcomes include the generation of policies and practices to reduce the drivers of young people leaving approved placements and to address the support and protective needs of young people when staying in unapproved locations. The benefits include improved social and economic inclusion of young people in out-of-home care and reduced socio-economic burdens on health and justice systems associated with placement breakdown. Read moreRead less
The Impact Of Therapy On T-cell Recognition Of Mutated Tumour Neo-antigens
Funder
National Health and Medical Research Council
Funding Amount
$1,126,685.00
Summary
Cancer is caused by mutations which should be 'seen' and destroyed by the patients immune cells, similar to how immune cells protect us against viruses. But they don't. This grant will study how current cancer treatments help the immune cells 'see' these mutations. We will undertake these studies in the important cancers lung cancer and mesothelioma.
Living as a child: children's experiences in England c. 1400-1750. How we best nurture and socialize the next generation of Australians is currently a matter of critical debate. Yet modern Australian attitudes to childhood and practices of child-rearing were first formed in the crucible of pre-modern Europe. Our proposed history of children's experiences in England c. 1400-1750 will provide a rich understanding of the foundations of present-day theories and practices of child-rearing. It will e ....Living as a child: children's experiences in England c. 1400-1750. How we best nurture and socialize the next generation of Australians is currently a matter of critical debate. Yet modern Australian attitudes to childhood and practices of child-rearing were first formed in the crucible of pre-modern Europe. Our proposed history of children's experiences in England c. 1400-1750 will provide a rich understanding of the foundations of present-day theories and practices of child-rearing. It will enable us to distinguish universal features of child-rearing from those which change over time, and to maintain Australia's international reputation for top-class research and research training in pre-modern history and culture.Read moreRead less
A Study Of Artemisinin Combination Therapy Given At Delivery To Prevent Postpartum Malaria And To Young Infants To Treat Uncomplicated Malaria
Funder
National Health and Medical Research Council
Funding Amount
$788,850.00
Summary
The proposed studies will investigate the preventive value of a course of combination antimalarial treatment at delivery in pregnant women in malarial areas. The transfer of this treatment into breast milk and to the suckling infant will be investigated since this may protect the infant against malaria but also cause drug-related side-effects. These data will be used, with a study of combination treatment in infants with malaria, to optimise dose regimens in this vulnerable group.
HABIT-ILE: A Randomised Trial Of Hand Arm Bimanual Intensive Training Including Lower Extremity Training For Children With Bilateral Cerebral Palsy
Funder
National Health and Medical Research Council
Funding Amount
$1,100,903.00
Summary
In Australia, 35,000 people have cerebral palsy, and between 60-70% experience difficulties with movement on both sides of their body. There are currently no effective interventions for children with bilateral CP to improve their ability to use their hands, walk and perform daily life tasks. We have promising data about a new intervention, called HABIT-ILE, which we will test in 80 children with cerebral palsy and compare results to usual care.
Discovery Early Career Researcher Award - Grant ID: DE230101520
Funder
Australian Research Council
Funding Amount
$375,573.00
Summary
Work fragmentation in the gig economy. The gig economy has fragmented working arrangements in Australia and globally, disrupting how, where and on what terms work is performed. This study will systematically interrogate the consequences for work and workers in Australia of the growth and diversification of gig work. It will use a labour geography approach to explain how workers navigate working in the gig economy in the context of their wider lives. This will extend existing research by groundin ....Work fragmentation in the gig economy. The gig economy has fragmented working arrangements in Australia and globally, disrupting how, where and on what terms work is performed. This study will systematically interrogate the consequences for work and workers in Australia of the growth and diversification of gig work. It will use a labour geography approach to explain how workers navigate working in the gig economy in the context of their wider lives. This will extend existing research by grounding analysis in the lived experience of workers both across various segments of the gig economy and over time. The project will extend academic theory and provide guidance to policymakers as to how to harness the benefits of gig work while mitigating potential harm.Read moreRead less