Omega-3 fatty acids, appetite and growth in farmed fish. Australia has very limited wild fish supplies, and with the increasing realization of human health benefits of fish (i.e. omega-3 fatty acid) there is a need to increase availability through aquaculture. However, feeds used in aquaculture contain costly fish oil with limited global supplies. Attempts made to substitute fish oil with vegetable sources in aquaculture feeds have been mixed. This international, comparative and multidisciplinar ....Omega-3 fatty acids, appetite and growth in farmed fish. Australia has very limited wild fish supplies, and with the increasing realization of human health benefits of fish (i.e. omega-3 fatty acid) there is a need to increase availability through aquaculture. However, feeds used in aquaculture contain costly fish oil with limited global supplies. Attempts made to substitute fish oil with vegetable sources in aquaculture feeds have been mixed. This international, comparative and multidisciplinary project aims to reduce the dependence on fish oils through investigation of basic fatty acid metabolism and endocrinology on farmed fish to ensure that human health promoting characteristics in the final product are retained.Read moreRead less
Understanding fish-killing mechanisms by harmful algal blooms: towards the design of effective mitigation strategies. Fish-killing microalgal blooms cause multi-million dollar losses to global aquaculture and wild fisheries. This project brings together leading Australian and Canadian research teams, applying sophisticated cell line and biologically active molecule technologies, to elucidate precise fish-kill mechanisms and design effective mitigation strategies.
Fighting disease on farms: how do vaccinations drive evolution of new pathogen strains? Vaccinating against some types of infectious diseases can drive evolution of new variants of the pathogen. This project will show how bacterial populations evolve in response to vaccination in farms, leading to new vaccination strategies and improved vaccine formulations to better control diseases that are caused by highly variable bacteria.
Characterisation of vital carbohydrate synthases in pathogenic oomycetes. This project aims to understand the mechanisms that control cell wall stability in the fish pathogen, Saprolegnia parasitica. The biochemical properties and function of vital enzymes involved in cell wall biosynthesis will be determined using innovative approaches at the interface of biochemistry, microbiology, cell biology, and structural biology. Next generation ion mobility mass spectrometry will be used to solve challe ....Characterisation of vital carbohydrate synthases in pathogenic oomycetes. This project aims to understand the mechanisms that control cell wall stability in the fish pathogen, Saprolegnia parasitica. The biochemical properties and function of vital enzymes involved in cell wall biosynthesis will be determined using innovative approaches at the interface of biochemistry, microbiology, cell biology, and structural biology. Next generation ion mobility mass spectrometry will be used to solve challenging structural questions that cannot be tackled with conventional techniques. Expected outcomes include new knowledge on challenging membrane proteins that allows development of novel strategies for disease control in aquaculture. The data may also be applicable to crop protection from related plant pathogens.Read moreRead less
The effect of de-gassing on the dispersion and stability of emulsions and colloidal solutions. Although it is widely accepted that oil and water will not mix, the reverse has recently been found to occur (by the applicant) under the unusual conditions of complete de-gassing. This discovery has opened up new areas for investigation and for the development of new processes and products. Hydrocarbon oils and hydrophobic powders can now be readily dispersed in water without the use of additives. Ho ....The effect of de-gassing on the dispersion and stability of emulsions and colloidal solutions. Although it is widely accepted that oil and water will not mix, the reverse has recently been found to occur (by the applicant) under the unusual conditions of complete de-gassing. This discovery has opened up new areas for investigation and for the development of new processes and products. Hydrocarbon oils and hydrophobic powders can now be readily dispersed in water without the use of additives. However, the mechanisms involved have not yet been elucidated and it is the aim of this project to understand the process and develop potential commercial applications.Read moreRead less
Triggering the dormant capacity of fish to make omega 3 fatty acids. Marine fisheries cannot expand further, leaving aquaculture (fish farming) with the challenge of meeting the growing demand for fish, whose consumption is known to enhance human health. Fish oil is an essential component of the feed used in aquaculture, but there is a decreasing global supply of this commodity. This innovative nutritional biochemistry project boosts the capacity of fish to produce their own fish oil from vegeta ....Triggering the dormant capacity of fish to make omega 3 fatty acids. Marine fisheries cannot expand further, leaving aquaculture (fish farming) with the challenge of meeting the growing demand for fish, whose consumption is known to enhance human health. Fish oil is an essential component of the feed used in aquaculture, but there is a decreasing global supply of this commodity. This innovative nutritional biochemistry project boosts the capacity of fish to produce their own fish oil from vegetable oils in their diet. Therefore, this project will enable the expansion of aquaculture as an economically and environmentally sustainable means to produce the highest quality, nourishing fish for human consumption.Read moreRead less
Water at Hydrophobic Surfaces. The properties of water define the nature of life on this planet. When water encounters a hydrophobic surface - at the air/water interface, in contact with unreactive solids such as Teflon, or at an oil drop, our recent experiments indicate that the water dissociates more readily into protons and hydroxide ions - undergoes autolysis - than in bulk water. Furthermore, the hydroxide ions are preferentially adsorbed at the surface, giving it a negative charge. This pr ....Water at Hydrophobic Surfaces. The properties of water define the nature of life on this planet. When water encounters a hydrophobic surface - at the air/water interface, in contact with unreactive solids such as Teflon, or at an oil drop, our recent experiments indicate that the water dissociates more readily into protons and hydroxide ions - undergoes autolysis - than in bulk water. Furthermore, the hydroxide ions are preferentially adsorbed at the surface, giving it a negative charge. This project will test the generality and implications of this novel concept. The results will range across physics, chemistry, biology and their associated technologies, a consequence of the ubiquitous importance of water. Read moreRead less
Constrained Receding Horizon Control of Nonlinear Systems. Most real world control problems involve the design of strategies that
achieve performance goals in the presence of constraints on the system variables. Receding horizon control is a strategy that addresses this problem by directly optimising performance under the appropriate constraints. This project will address theoretical and computational issues associated with this methodology. The expected outcomes include:
* New finitely p ....Constrained Receding Horizon Control of Nonlinear Systems. Most real world control problems involve the design of strategies that
achieve performance goals in the presence of constraints on the system variables. Receding horizon control is a strategy that addresses this problem by directly optimising performance under the appropriate constraints. This project will address theoretical and computational issues associated with this methodology. The expected outcomes include:
* New finitely parameterised solutions for nonlinear systems.
* Implementations of reduced computational complexity.
* New insights into analytical properties of the methodology.
These outcomes are expected to add to Australian scientific recognition and to bring significant economic benefit to Australian industry.
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Natriuretic peptide hormones and the stress response of fish. There are two main benefits of our research to Australia. Firstly, the team that we have assembled have international reputations, and include scientists from overseas. This team will be led by Australian Institutions and will put Australian science in the forefront of a competitive field, internationally. Secondly, our research examines questions that are critical in our understanding of how animals respond to stressful events. T ....Natriuretic peptide hormones and the stress response of fish. There are two main benefits of our research to Australia. Firstly, the team that we have assembled have international reputations, and include scientists from overseas. This team will be led by Australian Institutions and will put Australian science in the forefront of a competitive field, internationally. Secondly, our research examines questions that are critical in our understanding of how animals respond to stressful events. The response to stress, if excessive, leads to ill-health in both humans and other animals. Our research examines new connections between stress and fish biology, which could lead to discoveries that are valuable in managing stress and health in wild and farmed fishes.Read moreRead less
Programming of appetite and bodyweight by the interaction of maternal diet and angiotensin during peri-natal life. The project describes a phenotype for appetite and body weight that can be altered by maternal dietary omega-3 PUFA (environmental factors), at a critical period during peri-natal life (developmental phase) and that the effect on body weight is opposite when endogenous angiotensin is increased (hormonal factor). The project aims to discover how these different factors interact to p ....Programming of appetite and bodyweight by the interaction of maternal diet and angiotensin during peri-natal life. The project describes a phenotype for appetite and body weight that can be altered by maternal dietary omega-3 PUFA (environmental factors), at a critical period during peri-natal life (developmental phase) and that the effect on body weight is opposite when endogenous angiotensin is increased (hormonal factor). The project aims to discover how these different factors interact to produce the phenotype by defining the critical period and systematically identifying genes that are expressed during this period. The effect of manipulating maternal dietary omega-3 PUFA and the role of angiotensin will then be examined. The project will discover how genetic, hormonal and environmental factors interact during the perinatal period of life to program food intake and body weight in adult life. Read moreRead less