Mathematical models of diseases with complex transmission routes. This project aims to model diseases that spread via a mixture of routes including food, water, the environment, and direct spread between individuals. Key diseases include: avian influenza, which causes massive disruption to the poultry industry; gastroenteritis, which costs Australia $1,250 million each year; and leptospirosis, which causes one million severe illnesses each year globally. This project will develop mathematical a ....Mathematical models of diseases with complex transmission routes. This project aims to model diseases that spread via a mixture of routes including food, water, the environment, and direct spread between individuals. Key diseases include: avian influenza, which causes massive disruption to the poultry industry; gastroenteritis, which costs Australia $1,250 million each year; and leptospirosis, which causes one million severe illnesses each year globally. This project will develop mathematical and statistical tools to better estimate risk, analyse outbreak data, and provide guidance for disease control. This research will improve policy and enhance our ability to respond to disease outbreaks.Read moreRead less
Indigenous Australians and alcohol control: The impact of hotel ownership on harm reduction and social and economic development. This project investigates Indigenous social enterprise that intersects with the alcohol industry. Findings will benefit the Indigenous governing bodies of licensed premises and their communities, health and liquor regulation authorities and the country as a whole. The research addresses policy uncertainty surrounding Indigenous ownership of licensed premises and whethe ....Indigenous Australians and alcohol control: The impact of hotel ownership on harm reduction and social and economic development. This project investigates Indigenous social enterprise that intersects with the alcohol industry. Findings will benefit the Indigenous governing bodies of licensed premises and their communities, health and liquor regulation authorities and the country as a whole. The research addresses policy uncertainty surrounding Indigenous ownership of licensed premises and whether this achieves anticipated economic and social goals and reduces alcohol-related problems. Harm minimisation is an object of liquor licensing acts in most jurisdictions in Australia. Indigenous-owned licensed premises are well-placed to implement responsible alcohol service and promote harm minimisation in keeping with Australian best practice.Read moreRead less
The New Collaborative Environmental Governance: Natural Resource Management in Australia. This project will evaluate the new regional natural resource management arrangements that have been established across Australia. The project outcomes will enable policy-makers nationally to identify opportunities for innovative policies and programs which can achieve better results for the environment (reducing environmental degradation), and for the economy (reducing costs to rural industries and to regul ....The New Collaborative Environmental Governance: Natural Resource Management in Australia. This project will evaluate the new regional natural resource management arrangements that have been established across Australia. The project outcomes will enable policy-makers nationally to identify opportunities for innovative policies and programs which can achieve better results for the environment (reducing environmental degradation), and for the economy (reducing costs to rural industries and to regulators) while substantially increasing effective community participation. The project will also provide principles with the potential to reshape environmental strategy and establish Australia as a leader in collaborative environmental governance internationally.Read moreRead less
Dissecting a RNA-histone variant interaction and its role in splicing. This project aims to define the molecular details of how a chromatin component, histone H2A.B, binds RNA and influences RNA splicing. This is unprecedented for histones, which are typically associated with DNA and transcriptional regulation. Over 90 per cent of human genes may be alternatively spliced. This explains how complex organisms develop from a limited set of genes, but how alternative splicing decisions are made is u ....Dissecting a RNA-histone variant interaction and its role in splicing. This project aims to define the molecular details of how a chromatin component, histone H2A.B, binds RNA and influences RNA splicing. This is unprecedented for histones, which are typically associated with DNA and transcriptional regulation. Over 90 per cent of human genes may be alternatively spliced. This explains how complex organisms develop from a limited set of genes, but how alternative splicing decisions are made is unclear. The intended outcome is to reveal links between chromatin, RNA splicing and gene expression regulation to explain how multicellular organisms have evolved. The translation of this knowledge will ultimately provide long-term economic and health benefits for Australia.Read moreRead less
Understanding how dynamic changes in chromatin composition control genome function. DNA is tightly packaged in eukaryotic cells as chromatin. Important genetic processes, such as transcription, require manipulation of chromatin structure to access the DNA. The cell sets up specialised chromatin structures to regulate these processes. Currently, precise molecular details of these specialised structures are limited. This project will push the envelope of an in vitro model chromatin system and dete ....Understanding how dynamic changes in chromatin composition control genome function. DNA is tightly packaged in eukaryotic cells as chromatin. Important genetic processes, such as transcription, require manipulation of chromatin structure to access the DNA. The cell sets up specialised chromatin structures to regulate these processes. Currently, precise molecular details of these specialised structures are limited. This project will push the envelope of an in vitro model chromatin system and determine the architecture of several chromatin states with unique functional implications inside the cell. This will unravel the molecular instructions that define how our genomes are organised, significantly advancing our knowledge of fundamental eukaryotic genome biology and paving the way for the future development of new tools and therapies.Read moreRead less
The social and environmental implications of privately regulated food quality standards for agri-food networks in Asia-Pacific. This proposal will contribute to an environmentally sustainable Australia in two ways. First, the research will highlight barriers to the uptake of environmental standards among fruit and vegetable growers as well as potential strategies to encourage certification. Second, the research will assess the extent to which compliance with internationally harmonised standards ....The social and environmental implications of privately regulated food quality standards for agri-food networks in Asia-Pacific. This proposal will contribute to an environmentally sustainable Australia in two ways. First, the research will highlight barriers to the uptake of environmental standards among fruit and vegetable growers as well as potential strategies to encourage certification. Second, the research will assess the extent to which compliance with internationally harmonised standards actually assists or encourages farmers to address local priority environmental issues. Improved understanding of the social and environmental impact of standards will highlight domestic policy and regulatory shifts which may be necessary to maximise positive environmental outcomes.Read moreRead less
Climate Change Projections and Policy Design Under Uncertainty. The issue of climate change and policy responses is one of the most important questions facing the world today. This research develops a global framework for understanding the many complexities surrounding this issue, for undertaking projections of emissions, for evaluating alternative policy proposals and for developing new policies. In particular it will provide a framework for undertaking alternative scenarios about future econom ....Climate Change Projections and Policy Design Under Uncertainty. The issue of climate change and policy responses is one of the most important questions facing the world today. This research develops a global framework for understanding the many complexities surrounding this issue, for undertaking projections of emissions, for evaluating alternative policy proposals and for developing new policies. In particular it will provide a framework for undertaking alternative scenarios about future economic growth and carbon emissions and attempt to quantify uncertainties. It will also focus on major developing countries such as China and India which will be critical in the future evolution of world economic activity and greenhouse emissions.Read moreRead less
Molecular characterisation of the Prf bacterial recognition complex of tomato. This project will investigate the composition and function of a large protein complex in tomatoes that controls their ability to resist attack by bacteria. The results will provide understanding to how all plants resist all diseases, and may help to improve environmentally-benign disease resistance in crop species.
Chromatin structure and pervasive transcription. This project aims to understand mechanisms that repress pervasive transcription and to identify chromatin characteristics that repress transcription initiation outside the promoter regions. Chromatin characteristics, such as position, occupancy and turnover-rate of nucleosomes, establish an elaborate genomic indexing mechanism, which defines functional units in the genome. Defects in this process increase pervasive transcription, toxic accumulatio ....Chromatin structure and pervasive transcription. This project aims to understand mechanisms that repress pervasive transcription and to identify chromatin characteristics that repress transcription initiation outside the promoter regions. Chromatin characteristics, such as position, occupancy and turnover-rate of nucleosomes, establish an elaborate genomic indexing mechanism, which defines functional units in the genome. Defects in this process increase pervasive transcription, toxic accumulation of non-coding transcripts and genomic instability. This work aims to understand eukaryotic genome organisation and may have long-term therapeutic implications for cancer and ageing-related diseases.Read moreRead less
Tracking factor footprints to reveal the intricacy and control of translation initiation. Messenger ribonucleic acid (RNA) translation is required for all of life and knowledge of how it works is central to modern life sciences. This project will develop novel ways of studying translation, generating entirely new descriptions of its inner workings that may transform knowledge of gene function and its use in medical and biotechnological processes.