Towards Scalable, Internet-Based RFID Traceability Networks. Food and drug safety is a major public health issue in Australia. Recent events involving poisoning of chocolate bars and paracetamol tablets in Australia have demonstrated the urgent need for improved ways of locating and recalling commercial products that have been released into the community. This project will develop novel techniques for locating items in large-scale distribution networks driven by RFID (Radio Frequency Identificat ....Towards Scalable, Internet-Based RFID Traceability Networks. Food and drug safety is a major public health issue in Australia. Recent events involving poisoning of chocolate bars and paracetamol tablets in Australia have demonstrated the urgent need for improved ways of locating and recalling commercial products that have been released into the community. This project will develop novel techniques for locating items in large-scale distribution networks driven by RFID (Radio Frequency Identification) technology. The outcomes of the project will make it easier to rapidly and accurately pinpoint product locations in the event of problems such as an illness outbreak due to contaminated food or counterfeited drugs. Read moreRead less
Globalization, WTO and sustainable development: new challenges, opportunities and implications for Australia. Australia is benefiting greatly from opening its economy and encouraging the same in its trading partners, particularly through the World Trade Organization (WTO). A major new challenge is to ensure that the WTO continues to enhance economic welfare by responding to recent criticisms levelled at it by anti-globalization groups. This project will analyse those groups' claims about the eff ....Globalization, WTO and sustainable development: new challenges, opportunities and implications for Australia. Australia is benefiting greatly from opening its economy and encouraging the same in its trading partners, particularly through the World Trade Organization (WTO). A major new challenge is to ensure that the WTO continues to enhance economic welfare by responding to recent criticisms levelled at it by anti-globalization groups. This project will analyse those groups' claims about the effects of trade and investment policy reforms, and of WTO rules and other contributors to globalization, by going beyond the traditional economic effects to examine effects on income distribution, poverty alleviation, the environment, labour, and food safety and security.Read moreRead less
Three-dimensional structures, substrate specificities and catalytic mechanisms of polysaccharide synthases. Plant wall polysaccharides are extensively used for food and fibre, and are important dietary components in human nutrition. A precise knowledge of mechanisms used by plants to synthesize these polysaccharides is unavailable, but would reveal potential routes to manipulate their biosynthesis in important crop species. For example, the levels or structures of polysaccharides might be modif ....Three-dimensional structures, substrate specificities and catalytic mechanisms of polysaccharide synthases. Plant wall polysaccharides are extensively used for food and fibre, and are important dietary components in human nutrition. A precise knowledge of mechanisms used by plants to synthesize these polysaccharides is unavailable, but would reveal potential routes to manipulate their biosynthesis in important crop species. For example, the levels or structures of polysaccharides might be modified to improve their efficacy as anti-cancer agents in human diets, to enhance digestibility of animal stock feeds, or to synthesise pharmologically valuable compounds. Thus, economic, social and environmental benefits will flow to both producers and consumers. Read moreRead less
Identification of Biological pathways regulated by circular RNAs. Circular RNAs (circRNAs) are a, recently discovered molecule. circRNAs are highly abundant and expressed in a tissue and disease specific manner. Yet, currently the understanding of how circRNAs regulate biological processes is very poor. This project aims to use pooled shRNA libraries to screen a large panel of cell lines and systematically identify cellular activities that are regulated by circRNAs. The expected outcome of this ....Identification of Biological pathways regulated by circular RNAs. Circular RNAs (circRNAs) are a, recently discovered molecule. circRNAs are highly abundant and expressed in a tissue and disease specific manner. Yet, currently the understanding of how circRNAs regulate biological processes is very poor. This project aims to use pooled shRNA libraries to screen a large panel of cell lines and systematically identify cellular activities that are regulated by circRNAs. The expected outcome of this study will be a catalogue of functionally active circRNAs. Over the past decades, the wealth of knowledge on the function of linear mRNAs has had a significant impact on medicine and agriculture. Similarly understanding how circRNAs regulate cellular activities may have an analogous impact on humans.Read moreRead less
Defining how molecular switches program cell identity during development. Aims: This project aims to investigate how molecular switches known as transcription factors, work together to turn genes on or off to program cell identity during development.
Significance: This project expects to generate new knowledge in the area of genetics and developmental biology using collaborative, cutting edge technologies.
Outcomes: Expected outcomes of this project include the identification of new genes impor ....Defining how molecular switches program cell identity during development. Aims: This project aims to investigate how molecular switches known as transcription factors, work together to turn genes on or off to program cell identity during development.
Significance: This project expects to generate new knowledge in the area of genetics and developmental biology using collaborative, cutting edge technologies.
Outcomes: Expected outcomes of this project include the identification of new genes important for programming the identity of cells that comprise our blood vessels, lymphatic vessels and circulating blood cells.
Benefits: Data generated will underpin the development of approaches to program/reprogram stem cells to produce mature cells for transplantation or tissue engineering purposes ex vivo.Read moreRead less
Revealing molecular detail of DNA triplexes to underpin antigene technology. Variations from the classic DNA double helix structure are proposed to play key roles in a range of cellular processes, particularly gene regulation. However, the biological function and therapeutic potential of these unusual DNA structures are poorly explored, since the fundamental molecular details which govern their formation and interactions with cellular machinery are not well described. This project aims to develo ....Revealing molecular detail of DNA triplexes to underpin antigene technology. Variations from the classic DNA double helix structure are proposed to play key roles in a range of cellular processes, particularly gene regulation. However, the biological function and therapeutic potential of these unusual DNA structures are poorly explored, since the fundamental molecular details which govern their formation and interactions with cellular machinery are not well described. This project aims to develop innovative methods to investigate, and importantly modulate, DNA and RNA triple helix assembly, specificity and molecular interactions. Resulting insights will underpin novel approaches to gene regulation, principally in the context of designing new antibacterial agents to address the antibacterial resistance problem.Read moreRead less
Road rules for traffic on DNA - gene regulation by encounters between transcribing RNA polymerases and DNA-bound proteins. This project addresses a widespread but poorly understood phenomenon in gene regulation. The work will support Australian industries by supplying new tools for manipulation of gene expression for industrial and medical applications and will provide unique opportunities for Australian students in this emerging field.
Building bio-inspired smart nanochannels for virus detection. This project aims to harness high-precision silicon nanofabrication methods to create the next generation of bio-inspired viral biosensors. The new technology would enable prompt, cost-efficient, and accurate detection of virus contamination of our water and food supplies. The project plans to fabricate arrays of parallel double-layered nanochannels in silicon via templated etching, with surface functionalisation to display receptors. ....Building bio-inspired smart nanochannels for virus detection. This project aims to harness high-precision silicon nanofabrication methods to create the next generation of bio-inspired viral biosensors. The new technology would enable prompt, cost-efficient, and accurate detection of virus contamination of our water and food supplies. The project plans to fabricate arrays of parallel double-layered nanochannels in silicon via templated etching, with surface functionalisation to display receptors. These nanochannels are designed to act as size-selective filters for electrochemical and electrochemiluminescence sensing. The project plans to explore innovative signal amplification and multiplexing capabilities for ultrasensitive detection of norovirus and bacteriophages.Read moreRead less
Non-coding RNAs in mammalian reproduction. This project aims to investigate the role of non-coding RNAs in mammalian sex chromosome biology and reproduction. Non-protein coding RNAs are a major regulatory mechanism in eukaryotic genomes; they can bind other RNAs or chromatin modifying complexes. However, the evolutionary trajectory and function of non-coding RNAs in sex chromosome biology and sexual development is largely unknown. This project will study non-coding RNAs in Australian mammals to ....Non-coding RNAs in mammalian reproduction. This project aims to investigate the role of non-coding RNAs in mammalian sex chromosome biology and reproduction. Non-protein coding RNAs are a major regulatory mechanism in eukaryotic genomes; they can bind other RNAs or chromatin modifying complexes. However, the evolutionary trajectory and function of non-coding RNAs in sex chromosome biology and sexual development is largely unknown. This project will study non-coding RNAs in Australian mammals to try to answer fundamental questions about how non-coding RNAs function in mammalian sexual development.Read moreRead less
Diversity in large crop genomes via enhanced recombination. The project aims to understand genetic and environmental factors that limit how fast genomic combinations can be generated by modifying the recombination rates between chromosomes. Plant breeding is based around genetic diversity, but modern breeding programs have captured only a small proportion of the variation available in wild relatives and land races. Knowledge of diversity in this wild germplasm pool is increasing and the challeng ....Diversity in large crop genomes via enhanced recombination. The project aims to understand genetic and environmental factors that limit how fast genomic combinations can be generated by modifying the recombination rates between chromosomes. Plant breeding is based around genetic diversity, but modern breeding programs have captured only a small proportion of the variation available in wild relatives and land races. Knowledge of diversity in this wild germplasm pool is increasing and the challenge is to quickly and efficiently introduce this variation into elite lines. This project’s findings are expected to transform wheat and barley breeding methods by unlocking the genetic diversity to produce new varieties. This will enhance and protect a critical and valuable rural industry.Read moreRead less