Osteoporotic Fracture-Mortality Association And The Effect Of Anti-osteoporosis Treatment: A Multinational Study
Funder
National Health and Medical Research Council
Funding Amount
$84,800.00
Summary
Osteoporosis burden is due primarily to osteoporotic fractures resulting in economic and public health burden, increased disability, further fracture risk and more importantly early death. However, it remains under-treated although treatment reduces the number of fractures and may reduce early death. This study aims to understand which types of fractures result in early death and for which age groups and whether osteoporosis treatment does or does not reduce early death.
Geelong Osteoporosis Study: Fracture Risk Prediction Based On Twenty Years Of Prospective Data.
Funder
National Health and Medical Research Council
Funding Amount
$1,107,758.00
Summary
In this population-based study we will generate evidence, both environmental and genetic, for defining fracture risk in Australian men and women. This will help identify individuals likely to sustain fragility fractures so that suitable therapies can be recommended. The data will be useful for developing prognostic models in both a clinical setting and for genetic screening programmes.
International Orthopaedic Multicenter Study In Fracture Care (INORMUS)
Funder
National Health and Medical Research Council
Funding Amount
$1,462,437.00
Summary
INORMUS is a global multi-centre prospective cohort study in 40,000 patients with musculoskeletal trauma (e.g. fractures or dislocations) to determine the incidence of major trauma complications (i.e. mortality, re-operations, and infections) and to examine a number of factors that may predict early complications. This study will allow us to address fundamental questions for the millions of adults worldwide who experience trauma annually and will have immense public health implications.
The study is the largest fracture care study will provide precise and accurate estimates of outcome in the early post injury period and enable determination of modifiable factors predicting major outcomes In NSW, the study results will identify limitations of the present compulsory third party (CTP) insurance scheme and help create a more efficient insurance scheme. This proposal involves an elite collaboration of researchers from Canada, Australia and South Asia.
Long Term Supplementation With Retinyl Palmitate (Vitamin A) And The Risk Of Bone Fractures: A Population Based Study.
Funder
National Health and Medical Research Council
Funding Amount
$167,707.00
Summary
Osteoporosis is a major health problem in Australia and other western industrialised countries where populations are increasingly ageing. In Australia, the number of hip fractures is expected to increase by 36% between 1996 and 2006, owing to the rise in elderly aged 85 years and over. This is in contrast to projections in Europe and North America, where the number of hip fractures are expected to double by 2026 and then stabilise. Clarification of the role of vitamin A in bone health is pertine ....Osteoporosis is a major health problem in Australia and other western industrialised countries where populations are increasingly ageing. In Australia, the number of hip fractures is expected to increase by 36% between 1996 and 2006, owing to the rise in elderly aged 85 years and over. This is in contrast to projections in Europe and North America, where the number of hip fractures are expected to double by 2026 and then stabilise. Clarification of the role of vitamin A in bone health is pertinent, given that the popularity of supplement use has increased markedly in western industrialised countries over the past two decades. Around 37% of the adult population in Australia is thought to take a supplement regularly and figures range from 28% to 54% of adults in the US, with women and adults aged over 49 years being more likely to use supplements. Furthermore, the fortification of food with minerals and vitamins is increasing. For all of these reasons, is it imperative that the role of vitamin A in inducing fractures be clarified. Results from this study will contribute to knowledge about the safety of retinol and beta carotene supplements in relation to bone health, which is especially relevant to people at risk of osteoporosis, and people who take vitamin A supplements. We will also be able to clarify the upper levels of dietary retinol, beta carotene and vitamin A intake beyond which fracture risk increases. Because of the age range of subjects in our study, our results should be applicable to the whole population, not only the elderly or post menopausal. The results of our study will be useful to agencies such as Food Standards Australia and New Zealand which regulates our food supply.Read moreRead less