Optimising Efficacy Of A Peptide Derived Against The Alpha-interacting Domain Of The L-type Calcium Channel In Reduction Of Ischemia-reperfusion Injury
Funder
National Health and Medical Research Council
Funding Amount
$405,063.00
Summary
A heart attack is associated with an increase in free radicals and calcium in heart muscle cells. The function of the L-type calcium channel, a protein responsible for calcium entry into cells, is altered by free radicals and this contributes to the development of heart disease. We now have considerable proof of concept that a peptide derived against the L-type calcium channel can decrease heart injury. We will optimise efficacy and delivery of the peptide to prevent heart failure.
Phase III Study Of The Impact Of A Physical Activity Program On Disease-free Survival For Early Colon Cancer
Funder
National Health and Medical Research Council
Funding Amount
$2,556,385.00
Summary
There is clear evidence that physical activity can reduce the risk of developing bowel cancer and some evidence suggesting it may decrease the risk of a recurrence of bowel cancer. This study will provide reliable evidence as to whether people who participate in a structured physical activity programme after treatment for stage II or III colorectal cancer can increase their likelihood of being alive without a cancer recurrence at three years, compared to those who have standard follow-up.