Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100190
Funder
Australian Research Council
Funding Amount
$620,000.00
Summary
Electrophysiology Platform for Ion-channel Characterisation. Ion channels are ubiquitous pore-forming membrane proteins, with the human genome encoding >300 ion channels. The diverse roles of ion channels include action potential generation, control of ion flow across secretory and epithelial cells, and regulation of cell volume, motility and proliferation. Pharmacological modulators are powerful tools for probing ion channel function, but for most channels these tools are lacking. Thus, this p .... Electrophysiology Platform for Ion-channel Characterisation. Ion channels are ubiquitous pore-forming membrane proteins, with the human genome encoding >300 ion channels. The diverse roles of ion channels include action potential generation, control of ion flow across secretory and epithelial cells, and regulation of cell volume, motility and proliferation. Pharmacological modulators are powerful tools for probing ion channel function, but for most channels these tools are lacking. Thus, this project aims to develop the first comprehensive toolbox of ion channel modulators using an integrated in vitro/in vivo electrophysiology platform. These pharmacological tools will be made freely available to the Australian research community for probing the mechanism and physiological function of ion channels.Read moreRead less
The role of the immune system in pain is emerging from recent discoveries, and may hold the key to novel pain treatments. Most people experience brief gut infections from food or contagion without long-term consequences. Many others suffer symptoms for years afterwards - probably the best example of immune-based pain. Our project investigates how immune cells communicate with sensory nerves, and how these communications change from both angles after gut infection or inflammation.
Transient Receptor Potential Channels (TRPs) As Transducers And Targets In Primary Visceral Afferents
Funder
National Health and Medical Research Council
Funding Amount
$669,130.00
Summary
Transient receptor potential, or TRP channels, are involved in generating many of the sensations we perceive, such as heat, cold, touch and pain. Some TRP channels are specialized to signal pain from visceral organs, which we must investigate if we are to find treatments for visceral pain, which are currently lacking.
A molecular/morphological view of animal evolution based on marsupials. This project aims to provide high-accuracy methods of evolutionary inference extendable to nearly all other organisms. It aims to research the evolution of animal diversity and calibrate evolutionary timescales on a case study of marsupial mammals, and differentiate between internal and external factors that govern animals’ ability to adapt and diversify. The project will collate a large, open-source three-dimensional catalo ....A molecular/morphological view of animal evolution based on marsupials. This project aims to provide high-accuracy methods of evolutionary inference extendable to nearly all other organisms. It aims to research the evolution of animal diversity and calibrate evolutionary timescales on a case study of marsupial mammals, and differentiate between internal and external factors that govern animals’ ability to adapt and diversify. The project will collate a large, open-source three-dimensional catalogue of the evolving marsupial skeleton, which could provide a detailed and publicly accessible narrative of the evolutionary past and future adaptability of Australian marsupials. The proposed development of methods to quantify the effect of past and present biodiversity crises (e.g. environmental change) is expected to inform longer-term conservation planning.Read moreRead less
Design of novel nanoporous semiconductor materials for clean environment and energy. This project will develop a low cost nanoporous semiconductor device for the capture and conversion of CO2 into fuels by using water and sunlight. This novel approach will deliver a low cost technology that offers clean energy and will help to mitigate global warming.
Discovery Early Career Researcher Award - Grant ID: DE170100510
Funder
Australian Research Council
Funding Amount
$350,977.00
Summary
How first-in-family males transition to Australian university life. This project aims to study how gender, ethnicity and social class affect Australian males from low socio-economic backgrounds as they transition to university. Despite an emphasis on widening participation in the Australian university sector, the path to university is still precarious, particularly for first-in-family students. Males from low socio-economic backgrounds remain severely underrepresented in higher education, and ho ....How first-in-family males transition to Australian university life. This project aims to study how gender, ethnicity and social class affect Australian males from low socio-economic backgrounds as they transition to university. Despite an emphasis on widening participation in the Australian university sector, the path to university is still precarious, particularly for first-in-family students. Males from low socio-economic backgrounds remain severely underrepresented in higher education, and how these students experience university life is unclear. The project will use qualitative research to better understand the experiences of first-in-family males entering universities in different locales/institutions across Australia. Expected outcomes include improved targeted support systems to enable their success.Read moreRead less
Reducing the deleterious impacts of clay particle interactions with valuable minerals in copper and gold processing. This project seeks to understand the rheological behaviour of clay minerals and the effect of the viscosity caused by clay minerals on gas dispersion, the transport of network structures and the locking of the structures in the froth in mineral flotation. Novel methods will be developed to improve flotation separation by reducing the viscosity.
Mandated literacy assessment and the reorganisation of teachers' work. The study will inform practitioners, teacher educators and educational policy-makers about the ways that teachers' work is being changed by the introduction of mandated standardised assessment and reporting processes. The research will provide insights into the ways in which teachers need to adapt standardised processes and policies to account for the varied student and community populations they serve. This is significant fo ....Mandated literacy assessment and the reorganisation of teachers' work. The study will inform practitioners, teacher educators and educational policy-makers about the ways that teachers' work is being changed by the introduction of mandated standardised assessment and reporting processes. The research will provide insights into the ways in which teachers need to adapt standardised processes and policies to account for the varied student and community populations they serve. This is significant for educational policy as recent international studies of students' literacy performance suggest Australia is lagging in terms of equity for low SES students. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100220
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
A study of the bulk and surface responses of ores to high voltage pulses applied using a selFrag Lab. Minerals account for 40% of Australia's exports and mining is a major Australian employer. The health of the industry is integral to Australia's prosperity. Recent events have shown that mining cannot rely on high commodity prices but must continually seek efficiency improvements. This will be even more critical as production depends increasingly on low-grade ore deposits. Using selFrag Lab, ....A study of the bulk and surface responses of ores to high voltage pulses applied using a selFrag Lab. Minerals account for 40% of Australia's exports and mining is a major Australian employer. The health of the industry is integral to Australia's prosperity. Recent events have shown that mining cannot rely on high commodity prices but must continually seek efficiency improvements. This will be even more critical as production depends increasingly on low-grade ore deposits. Using selFrag Lab, the response of different ores to high voltage pulses will be studied to identify processes that liberate a greater percentage of valuable minerals while using less energy and less water and keeping toxic elements bound in larger waste particles. SelFrag-based research will therefore deliver major economic and environmental benefits to Australia.Read moreRead less
Engineering the sulphidising reactions for flotation of low quality ores. Engineering the sulphidising reactions for flotation of low quality ores. This project aims to engineer sulphidisation reactions to enhance the flotation of low quality ores for the minerals industry. Sulphidisation uses flotation to enrich base metal and precious minerals from low quality ores containing oxides and oxidised sulphides before expensive leaching or smelting. However, the current sulphidisation method is neit ....Engineering the sulphidising reactions for flotation of low quality ores. Engineering the sulphidising reactions for flotation of low quality ores. This project aims to engineer sulphidisation reactions to enhance the flotation of low quality ores for the minerals industry. Sulphidisation uses flotation to enrich base metal and precious minerals from low quality ores containing oxides and oxidised sulphides before expensive leaching or smelting. However, the current sulphidisation method is neither efficient nor widely used. This project will tailor sulphidisation reactions to generate desirable surface products that are not sensitive to flotation conditions. The intended outcome of this project is to provide a step change value in processing low quality resources while minimising the environmental effects of stockpiles.Read moreRead less