Investigating The Cellular Response To Iron-Depletion: The Trilogy Of ASK1, Thioredoxin And Ribonucleotide Reductase
Funder
National Health and Medical Research Council
Funding Amount
$552,572.00
Summary
Iron is crucial for many essential biological processes. Recently, we demonstrated that iron-depletion can affects important signalling pathways (e.g., JNK and p38) that play important roles in growth arrest and apoptosis. This study is designed to investigate the cellular and molecular effects of iron depletion which currently remains unclear. The research is crucial for understanding: (1) the effects of iron deficiency and (2) for understanding the effects of iron chelators that are used for t ....Iron is crucial for many essential biological processes. Recently, we demonstrated that iron-depletion can affects important signalling pathways (e.g., JNK and p38) that play important roles in growth arrest and apoptosis. This study is designed to investigate the cellular and molecular effects of iron depletion which currently remains unclear. The research is crucial for understanding: (1) the effects of iron deficiency and (2) for understanding the effects of iron chelators that are used for treating various diseases.Read moreRead less
Unravelling the drivers of greenhouse gas emissions in estuaries. The aim of this project is to understand and quantify the factors controlling the emission of carbon dioxide, methane and nitrous oxide from estuaries. Coastal systems play a disproportionately large role in the global emissions of greenhouse gases, but this is poorly quantified. The project plans to use a combination of continuous concentration and stable isotope measurements, process measurements and advanced numerical modelling ....Unravelling the drivers of greenhouse gas emissions in estuaries. The aim of this project is to understand and quantify the factors controlling the emission of carbon dioxide, methane and nitrous oxide from estuaries. Coastal systems play a disproportionately large role in the global emissions of greenhouse gases, but this is poorly quantified. The project plans to use a combination of continuous concentration and stable isotope measurements, process measurements and advanced numerical modelling across a range of undisturbed to disturbed systems. It is intended that this project will provide information for conceptualising, calibrating and verifying models, including green-house gas production. Good models, and the data that support them, such as that provided by this study, are critical for the efficient allocation of management resources in Australian coastal systems, including by our partners. The findings from this project will have direct implications to the management, rehabilitation and protection of waterways (including biodiversity) in Australia.Read moreRead less
Ecosystem resilience of Shark Bay under changing ocean climate. This project aims to investigate the resilience of the Shark Bay World Heritage Site to projected climate change. This project will generate new knowledge for marine conservation through analyses of habitat loss on nutrient budgets and productivity in seagrass and microbialite ecosystems. Expected outcomes are an improved understanding of climate-driven shifts on ecosystem processes in Shark Bay, incorporating science-based evidence ....Ecosystem resilience of Shark Bay under changing ocean climate. This project aims to investigate the resilience of the Shark Bay World Heritage Site to projected climate change. This project will generate new knowledge for marine conservation through analyses of habitat loss on nutrient budgets and productivity in seagrass and microbialite ecosystems. Expected outcomes are an improved understanding of climate-driven shifts on ecosystem processes in Shark Bay, incorporating science-based evidence for better conservation and management. This will provide significant benefits by contributing to the future-proofing of Shark Bay’s World Heritage values to climate change, and more broadly by demonstrating the consequences of the continued tropicalisation of Australia’s coastline.Read moreRead less
Utilising plant-sediment-feedbacks to enhance seagrass restoration. This project aims to investigate the role of sediment microbes in promoting the health of threatened seagrass species across Australia. This project expects to create new knowledge for enhancing restoration success for seagrasses by integrating macro and micro-ecology, environmental genomics, plant ecology and ecosystem function (e.g. nutrient and biogeochemistry cycling). Expected outcomes are new knowledge to enhance seagrass ....Utilising plant-sediment-feedbacks to enhance seagrass restoration. This project aims to investigate the role of sediment microbes in promoting the health of threatened seagrass species across Australia. This project expects to create new knowledge for enhancing restoration success for seagrasses by integrating macro and micro-ecology, environmental genomics, plant ecology and ecosystem function (e.g. nutrient and biogeochemistry cycling). Expected outcomes are new knowledge to enhance seagrass restoration utilising sediment microbes that can be integrated into management and policy. This project should provide significant benefits, such as the development of key strategic alliances to enhance management of seagrasses, and the ecosystem services, and economic and social benefits they provide.Read moreRead less
Unravelling the cycling of nitrogen along a subtropical freshwater-marine continuum using a multi-isotope, multi-tracer and modelling approach. This project will significantly advance our understanding of the sources, cycling and pathways of nitrogen along a sub-tropical catchment-river-estuary. As such, the findings from this research will have direct implications to the management, rehabilitation and protection of waterways (including biodiversity) in Australia.
Quantitative metrics for determining aquifer ecosystem state. Clean groundwater comes from dirty surface water by way of biological purification. This project will develop quantitative ways to assess groundwater ecosystems to ensure the sustainable extraction of water and maintenance of these crucial ecosystems.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100035
Funder
Australian Research Council
Funding Amount
$1,205,137.00
Summary
Founding an Australian Critical Zone Observatory Network. This proposal founds a new network of Australian Critical Zone Observatories. The network will fill essential knowledge gaps about interactions of under- and above-ground environmental processes and their responses to disturbance and change. These interactions determine the sustainability of food, clean water, mineral resources and Australian ecosystems, and cannot be studied with existing environmental infrastructure. The 5 foundation ....Founding an Australian Critical Zone Observatory Network. This proposal founds a new network of Australian Critical Zone Observatories. The network will fill essential knowledge gaps about interactions of under- and above-ground environmental processes and their responses to disturbance and change. These interactions determine the sustainability of food, clean water, mineral resources and Australian ecosystems, and cannot be studied with existing environmental infrastructure. The 5 foundational sites will host integrated monitoring equipment to observe stocks and fluxes of carbon, water, energy and mass across the “Critical Zone” – the vertical span from plant canopies to fresh bedrock. Joining a burgeoning international movement, the network will catalyse Critical Zone science in Australia.Read moreRead less
Examining scientific, philosophical, and folk perspectives on time=. This project aims to consider three very different physical theories, each of which reconciles quantum mechanics and general and special relativity in a different way. While science is more accessible than ever, we are increasingly faced with a scientific world-view that is antithetical to the way we see the world and experience ourselves in it. This project will consider the tension between the scientific picture of the world ....Examining scientific, philosophical, and folk perspectives on time=. This project aims to consider three very different physical theories, each of which reconciles quantum mechanics and general and special relativity in a different way. While science is more accessible than ever, we are increasingly faced with a scientific world-view that is antithetical to the way we see the world and experience ourselves in it. This project will consider the tension between the scientific picture of the world and our experience of the world, and aims to reconcile the two by bridging the gap between lived experience and scientific findings. The project will provide a range of ways of bridging the tension between these physical theories with our lived experience.Read moreRead less
Early Career Industry Fellowships - Grant ID: IE230100245
Funder
Australian Research Council
Funding Amount
$460,237.00
Summary
Transforming wastewater services in regional Australia. Wastewater treatment in regional Australia faces challenges of odour control, poor pollutant and pathogen removal, and greenhouse gas emissions. This project aims to innovatively use iron salts to realise highly efficient wastewater treatment in regional areas. With Partner, Western Australia Water Corporation, this project expects to leverage a recent breakthrough discovery on iron chemistry to co-develop and field test a solar system that ....Transforming wastewater services in regional Australia. Wastewater treatment in regional Australia faces challenges of odour control, poor pollutant and pathogen removal, and greenhouse gas emissions. This project aims to innovatively use iron salts to realise highly efficient wastewater treatment in regional areas. With Partner, Western Australia Water Corporation, this project expects to leverage a recent breakthrough discovery on iron chemistry to co-develop and field test a solar system that doses wastewater with iron, to overcome four challenges and a supply chain issue simultaneously. Expected outcomes include industry capacity to adopt and commercialise a novel technology with important global relevance. Outcomes should reduce the inequity of wastewater services in regional Australia.Read moreRead less