Novel Approaches To The Prevention And Treatment Of Chronic Heart Disease And Its Co-morbid Complications
Funder
National Health and Medical Research Council
Funding Amount
$5,793,580.00
Summary
Cardiovascular disease (CVD) and its associated additional disorders constitute major public health problems, especially given the rapidly ageing population which is increasingly affected by obesity and diabetes. This Program will explore novel therapies for the treatment of CVD and associated diseases, particularly focussing on chronic kidney disease, translating preliminary laboratory-based findings into clinical trials and then clinical and epidemiological findings into practice and policy.
Towards Prevention Of Acute Kidney Injury After Cardiac Surgery
Funder
National Health and Medical Research Council
Funding Amount
$771,918.00
Summary
Open heart surgery saves thousands of lives each year in Australia, but often injures the kidney. Kidney oxygen deficiency is a major cause of kidney injury. We propose a new way to manage kidney oxygen levels during heart surgery, by measuring the level of oxygen in the urine in the bladder. We will determine whether low levels of oxygen in the urine during surgery predict later development of acute kidney injury, and whether patient management can be changed to optimize kidney oxygen levels.
Exercise As Medicine For Heart Failure: A Novel Intervention To Improve Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$665,585.00
Summary
Heart failure (HF) is a common, debilitating and expensive disease; prognosis remains poorer than for the most cancers. 30,000 Australians are diagnosed every year and 300,000 live with the HF, at an annual cost of ~$1Billion. Exercise training is effective therapy in HF, because it reverses many of the problems that contribute to the reduced lifespan and impaired quality of life of patients with HF. We will test an exciting new type of exercise that promising greater benefit, at lower risk.
Identifying The Site/s Of Modification On The Human L-type Ca2+ Channel Protein Isoforms During Oxidative Stress With Reference To Development Of A Therapeutic Target
Funder
National Health and Medical Research Council
Funding Amount
$360,369.00
Summary
A rise in calcium and free radicals in the heart are associated with the development of heart disease. We have good evidence that a protein in the heart muscle known as the L-type calcium channel mediates changes in calcium in response to free radicals. This proposal will identify how the channel function is altered by free radicals so that a therapeutic target can be designed to prevent altered channel function and development of heart disease during increases in free radicals.
Keeping Kinship in Mind. This project aims to contribute to a better understanding of the study of kinship by drawing on recent research from the philosophy of mind and the philosophy of science. It will incorporate this understanding into a more general international, collaborative network in the philosophy of anthropology. Kinship has been central to anthropology as a discipline, with disagreement over the relationships between biological and cultural dimensions to kinship structuring much o ....Keeping Kinship in Mind. This project aims to contribute to a better understanding of the study of kinship by drawing on recent research from the philosophy of mind and the philosophy of science. It will incorporate this understanding into a more general international, collaborative network in the philosophy of anthropology. Kinship has been central to anthropology as a discipline, with disagreement over the relationships between biological and cultural dimensions to kinship structuring much of that history. Keeping Kinship in Mind will extend into the philosophy of the social sciences the productive interactions between philosophers and scientists that are an internationally recognized research strength of Australian philosophy of science. Read moreRead less
Between a hot place & hypoxia: Quantifying fish-kill risk in inland rivers. Native fish populations in Australian ephemeral rivers are highly valued but are subject to widespread decline. During drought waterholes serve as critical refuges for native fish, however thermal extremes and hypoxia (lack of oxygen) have led to regular fish-kill events. Whilst we know the general conditions that lead to fish-kills, we do not have a clear understanding of why some species are more tolerant than others, ....Between a hot place & hypoxia: Quantifying fish-kill risk in inland rivers. Native fish populations in Australian ephemeral rivers are highly valued but are subject to widespread decline. During drought waterholes serve as critical refuges for native fish, however thermal extremes and hypoxia (lack of oxygen) have led to regular fish-kill events. Whilst we know the general conditions that lead to fish-kills, we do not have a clear understanding of why some species are more tolerant than others, or how we can help decision-makers anticipate fish-kill risks. This project will combine laboratory ecophysiology investigations and novel field monitoring techniques to develop a next-generation fish habitat model for stakeholders to use to assess fish-kill risks and plan for restoration. Read moreRead less
The philosophical foundations of women’s rights: a new history, 1600-1750. This project aims to show that the history of women’s rights is much longer and richer than previously thought. There is a common perception that the notion of women’s rights first emerged in the late eighteenth century. This project expects to generate a new understanding of feminist history by investigating texts calling for the recognition of women’s dignity, worth, nobility, and excellence (cognate concepts to rights) ....The philosophical foundations of women’s rights: a new history, 1600-1750. This project aims to show that the history of women’s rights is much longer and richer than previously thought. There is a common perception that the notion of women’s rights first emerged in the late eighteenth century. This project expects to generate a new understanding of feminist history by investigating texts calling for the recognition of women’s dignity, worth, nobility, and excellence (cognate concepts to rights) in England and Europe from 1600 to 1750, against the backdrop of the rise of Cartesianism. The anticipated outcome is greater awareness of an enduring feminist tradition within the history of philosophy. The expected social benefits include a shift in public thinking about feminist history and women in philosophy.Read moreRead less
Examining scientific, philosophical, and folk perspectives on time=. This project aims to consider three very different physical theories, each of which reconciles quantum mechanics and general and special relativity in a different way. While science is more accessible than ever, we are increasingly faced with a scientific world-view that is antithetical to the way we see the world and experience ourselves in it. This project will consider the tension between the scientific picture of the world ....Examining scientific, philosophical, and folk perspectives on time=. This project aims to consider three very different physical theories, each of which reconciles quantum mechanics and general and special relativity in a different way. While science is more accessible than ever, we are increasingly faced with a scientific world-view that is antithetical to the way we see the world and experience ourselves in it. This project will consider the tension between the scientific picture of the world and our experience of the world, and aims to reconcile the two by bridging the gap between lived experience and scientific findings. The project will provide a range of ways of bridging the tension between these physical theories with our lived experience.Read moreRead less
Judgment, responsibility, and the life-world: The phenomenological critique of formalism. This project will contribute to building Australia's capacity in the area of phenomenology and connecting Australian researchers into the international network of phenomenology research. More generally the project will contribute to the broader community debate that is currently emerging around issues of the role and limits of knowledge, especially scientific knowledge, but also knowledge as it arises and i ....Judgment, responsibility, and the life-world: The phenomenological critique of formalism. This project will contribute to building Australia's capacity in the area of phenomenology and connecting Australian researchers into the international network of phenomenology research. More generally the project will contribute to the broader community debate that is currently emerging around issues of the role and limits of knowledge, especially scientific knowledge, but also knowledge as it arises and is applied in organisational and social contexts, and the importance of responsibility and judgment even in areas of technical problem-solving and decision-making. In this latter respect, the project is likely to have an impact in more directly applied areas such as policy formation and decision-making across many different areas.Read moreRead less