Control of developmental switches by importin 5. Aims: This project will study a key molecular switch called IPO5, a protein that is required for cells and organs to form and function normally, and it will reveal how it works.
Significance: These experiments will provide the first complete description of how this molecular switch controls the behaviour of a cell across its lifespan. IPO5 is highly conserved, so these studies will be relevant to a wide range of animals.
Expected Outcomes: This k ....Control of developmental switches by importin 5. Aims: This project will study a key molecular switch called IPO5, a protein that is required for cells and organs to form and function normally, and it will reveal how it works.
Significance: These experiments will provide the first complete description of how this molecular switch controls the behaviour of a cell across its lifespan. IPO5 is highly conserved, so these studies will be relevant to a wide range of animals.
Expected Outcomes: This knowledge will reveal how IPO5 controls formation of sperm by revealing what other proteins it binds to and how this affects cell signaling and responses to the environment.
Benefits: This will provide information about potential interventions to control fertility or to repair abnormal cells.
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The impact of environmental toxicants on the fertility of female animals. This study aims to address a problem of national significance; determining the impact of commonly used environmental toxicants (pesticides) on the fertility and health of female animals, both agricultural and native. This project expects to generate new knowledge in the fields of ovarian biology, female fertility and toxicology by using a combination of mouse and marsupial animal models. The expected outcomes include the e ....The impact of environmental toxicants on the fertility of female animals. This study aims to address a problem of national significance; determining the impact of commonly used environmental toxicants (pesticides) on the fertility and health of female animals, both agricultural and native. This project expects to generate new knowledge in the fields of ovarian biology, female fertility and toxicology by using a combination of mouse and marsupial animal models. The expected outcomes include the establishment of interdisciplinary collaborations and provision of world-class training for staff and students in the field of reproductive biology. This project should provide significant benefits, such as improved chemical management in livestock production and the development of marsupial conservation action plans.Read moreRead less
Ascorbate and glutathione integrate the control of grapevine development. This project aims to make a step-change in understanding how the growth of woody perennial crops is regulated. The study of herbaceous annual plants has established that the antioxidants, ascorbate and glutathione, are important in regulating every step of plant development. However, this cannot readily translate to perennial life cycles. This project will develop novel genetic tools in grapevine that enable functional stu ....Ascorbate and glutathione integrate the control of grapevine development. This project aims to make a step-change in understanding how the growth of woody perennial crops is regulated. The study of herbaceous annual plants has established that the antioxidants, ascorbate and glutathione, are important in regulating every step of plant development. However, this cannot readily translate to perennial life cycles. This project will develop novel genetic tools in grapevine that enable functional studies of these antioxidants in a perennial plant for the first time. It will investigate how ascorbate and glutathione regulate the development of grapevine, and how these functions integrate with hormone and energy metabolism. The outcomes will advance our ability to manage perennial crops in current and future climates.Read moreRead less
Improving plant reproductive success under heat stress: A sweet approach. This project aims to determine how genetic manipulation of cell wall invertase (CWIN) activity could regulate pollen germination, elongation and fruit set under heat stress using tomato as a model. Plant reproductive processes are highly susceptible to heat stress, which often leads to pollination failure and fruit and seed abortion, hence irreversible yield loss. Research has established that CWIN-mediated sugar metabolis ....Improving plant reproductive success under heat stress: A sweet approach. This project aims to determine how genetic manipulation of cell wall invertase (CWIN) activity could regulate pollen germination, elongation and fruit set under heat stress using tomato as a model. Plant reproductive processes are highly susceptible to heat stress, which often leads to pollination failure and fruit and seed abortion, hence irreversible yield loss. Research has established that CWIN-mediated sugar metabolism and signaling may play crucial roles in pollen growth and fruit set under heat stress. The intended outcome is the generation of critical knowledge that will advance understanding on reproductive development under heat stress, thereby providing significant benefits, such as novel ideas and solutions for improving crop yield.Read moreRead less
Unlocking secrets of fertility restoration for hybrid breeding in crops. Hybrid varieties give higher and more stable yields than conventional lines, but a cost-effective system to make hybrid seed on a commercial scale is still missing for economically important crops like wheat or barley. By elucidating the mode of action of a new type of restorer gene plus exploiting ancient or exotic wheat and barley collections this project will reveal aspects of largely understudied mechanisms underlying f ....Unlocking secrets of fertility restoration for hybrid breeding in crops. Hybrid varieties give higher and more stable yields than conventional lines, but a cost-effective system to make hybrid seed on a commercial scale is still missing for economically important crops like wheat or barley. By elucidating the mode of action of a new type of restorer gene plus exploiting ancient or exotic wheat and barley collections this project will reveal aspects of largely understudied mechanisms underlying fertility restoration in wheat and barley. The expected outcomes of the proposed research have the potential to deliver new tools for hybrid seed production programs in wheat and barley. Higher and more stable yields from hybrids will ensure food security in the face of an uncertain climate and growing human population.Read moreRead less
Child health and developmental inequities: Evidence for precision policy. The project aims to use cutting edge analytic approaches applied to existing data to identify how policy interventions related to parents’ mental health, preschool programs, and the built environment can be optimised to reduce inequities in children’s mental, academic, and physical health outcomes. The project will be informed by our partners and advisers from across government portfolios and service delivery, ensuring tha ....Child health and developmental inequities: Evidence for precision policy. The project aims to use cutting edge analytic approaches applied to existing data to identify how policy interventions related to parents’ mental health, preschool programs, and the built environment can be optimised to reduce inequities in children’s mental, academic, and physical health outcomes. The project will be informed by our partners and advisers from across government portfolios and service delivery, ensuring that the evidence generated has contemporary policy relevance. The project expects to identify clear and actionable policy pathways to reduce child inequities in Australia, which can benefit decision makers by helping them to direct limited public funds towards intervention opportunities that will have the greatest impact.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100663
Funder
Australian Research Council
Funding Amount
$440,850.00
Summary
The Real Price of Health: Experiences of Out-of-Pocket Costs in Australia. This project aims to investigate the experiences and preferences of Australian families and individuals on low, middle, and high incomes in managing the out-of-pocket costs of chronic disease. This project aspires to ensure outcomes that are relevant to the public and patients through involving people living with chronic disease in the research team. The project expects to generate a discrete choice model that describes p ....The Real Price of Health: Experiences of Out-of-Pocket Costs in Australia. This project aims to investigate the experiences and preferences of Australian families and individuals on low, middle, and high incomes in managing the out-of-pocket costs of chronic disease. This project aspires to ensure outcomes that are relevant to the public and patients through involving people living with chronic disease in the research team. The project expects to generate a discrete choice model that describes people with chronic diseases’ preferences, and the trade-offs that they are faced with when deciding how to manage out-of-pocket health costs. The evidence arising from this innovative study will be used to directly inform Australian health policy, leading to wide-ranging health and economic benefits for the whole community.Read moreRead less
Staffing practices in Aboriginal primary health care services. This project aims to generate new knowledge about the impact of short-term staffing in remote Aboriginal Community Controlled Health Services on service acceptability to patients, workload and attitudes of long-term staff and the effectiveness and cost of services. The project intends to compare these results to recent findings about the impact of short-term staffing in government-run clinics, in order to quantify and describe the po ....Staffing practices in Aboriginal primary health care services. This project aims to generate new knowledge about the impact of short-term staffing in remote Aboriginal Community Controlled Health Services on service acceptability to patients, workload and attitudes of long-term staff and the effectiveness and cost of services. The project intends to compare these results to recent findings about the impact of short-term staffing in government-run clinics, in order to quantify and describe the potential positive effect of community control. Expected outcomes include rigorous evidence about the 'fly in/fly out' workforce and the impact of community control which can inform new policy that will stabilise the remote health workforce, save money and contribute to 'closing the gap' in health outcomes.Read moreRead less
Early Career Industry Fellowships - Grant ID: IE230100561
Funder
Australian Research Council
Funding Amount
$452,936.00
Summary
Solving the disability data puzzle to ensure progress towards equity. In South Korea, the average age of death for people with disability is 16 years younger than people without disability. In Australia, we do not have the data infrastructure to generate life expectancy statistics for people with disability. This fellowship aims to solve this disability data challenge, identified as a critical problem by the Australian Government. It will develop a validated methodology for producing disability ....Solving the disability data puzzle to ensure progress towards equity. In South Korea, the average age of death for people with disability is 16 years younger than people without disability. In Australia, we do not have the data infrastructure to generate life expectancy statistics for people with disability. This fellowship aims to solve this disability data challenge, identified as a critical problem by the Australian Government. It will develop a validated methodology for producing disability statistics from linked data; generate a whole population disability data resource to build capacity in disability research; and for the first time, produce life expectancy statistics for people with disability - the ultimate policy tool to monitor progress towards equity and improve the lives of disabled Australians. Read moreRead less
Australian Laureate Fellowships - Grant ID: FL210100044
Funder
Australian Research Council
Funding Amount
$3,465,000.00
Summary
Governance for Planetary Health Equity. The Laureate Fellowship will use the novel lens of Planetary Health Equity to expose the importance of addressing planetary as well as human systems in achieving global health equity, and investigate the role of governance in realizing that aim. Using international and multi-sectoral comparative analysis, it intends to elucidate how institutions and actors can enable the development of coherent policy and business practices that advance planetary health eq ....Governance for Planetary Health Equity. The Laureate Fellowship will use the novel lens of Planetary Health Equity to expose the importance of addressing planetary as well as human systems in achieving global health equity, and investigate the role of governance in realizing that aim. Using international and multi-sectoral comparative analysis, it intends to elucidate how institutions and actors can enable the development of coherent policy and business practices that advance planetary health equity. Expected outcomes include the design of policies and business practices that promote planetary health equity and a governance framework that enables coherent action. The Laureate has the potential to reduce health inequities and climate change, and relieve pressure on health systems.Read moreRead less